Functional study on the regulatory role of reactive oxygen species-generating oxidase Nox1 in cancer development
| Project/Area Number |
22300328
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Shinshu University |
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Principal Investigator |
KAMATA Tohru 信州大学, 医学部, 教授 (40056304)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yoshifumi 信州大学, 医学部, 准教授 (50201893)
FURITA Syuichi 信州大学, 医学部, 助教 (80126705)
KATOH Masayoshi 信州大学, 医学部, 助教 (70402104)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKABAYASI Yuichi 新潟大学, 医歯学系, 准教授 (40303119)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | Nox4 / Ras, Wnt / 活性酸素 / EMT / HTLV -1 / Nox / 癌 / Wnt / Ras / モノクローナル抗体 |
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| Research Abstract |
Research effort has been made to investigate the functional role of ROS-generating Nox family enzymes in cancer development. We have found that Nox1 and Nox4 mediate cellular senescence, both Wnt-β-catenin signaling in colon cancer and recovery of inflammantion in the colon epithelium, and that Nox5 is required for adult T -cell leukemia virus-induced transformation. These results further support that Nox-derived ROS play an essential role in carcinogenesis and inflammation and underscore importance of Nox enzymes as therapeutic targets in cancer prevention.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration2010
Author(s)
Shinohara M, Adachi Y, Mitsushita J, Kuwabara M, Nagasawa A, Harada S, Furuta S, Zhang Y, Seheli K, Miyazaki H, Kamata T.
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Journal Title
J Biol Chem.
Volume: 285
Issue: 7
Pages: 4481-4488
DOI
NAID
Related Report
Peer Reviewed
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