| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Research Abstract |
In this study, we isolated and purified a tumor vascular endothelial cell specific monoclonal antibody as tumor targeting device. This monoclonal antibody which was labeled by RI functioned as a tumor imaging probe. Furthermore, we tried development as an imaging probe for immuno-PET/MRI using this antibody. As a result, we have established the technology to produce the PEGylated gold/iron oxide magnetic nanoparticles, which has modified monoclonal antibody on the tip of PEG chain, as a novel magneticresonance imaging agent.
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