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Development of multi-lateral cancer gene therapy by enhancing anti-tumor activity of inactivated Sendai virus particle

Research Project

Project/Area Number 22300339
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical oncology
Research InstitutionOsaka University

Principal Investigator

KANEDA Yasufumi  大阪大学, 大学院・医学系研究科, 教授 (10177537)

Co-Investigator(Kenkyū-buntansha) TANEMURA Atsushi  大阪大学, 大学院・医学系研究科, 助教 (50457016)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
KeywordsHVJ / 癌 / 抗腫瘍免疫 / アポトーシス / 遺伝子解析 / 遺伝子治療 / 核酸医薬
Research Abstract

We have reported that UV-inactivated Sendai virus particles (hemagglutinating virus of Japan envelope; HVJ-E) have multiple anti-tumor activities. Clinical application of HVJ-E has been started to evaluate the safety and efficacy of the particle in cancer patients. To enhance the anti-tumor activities, we attempted to incorporate therapeutic molecules into HVJ-E. As a result, HVJ-E containing IL2 or IL-12 gene enhanced anti-tumor immunity. HVJ-E having IL-12 polypeptide on the surface was developed and was more effective for the treatment of melanoma than original HVJ-E alone. Rad51 siRNA incorporated into HVJ-E augmented the effect of cancer treatment when combined with anti-tumor reagent, dacarbazine.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (8 results) (of which Invited: 1 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Systemic administration of a novel immune-stimulatory pseudovirion suppresses lung metastatic melanoma by regionally enhancing IFN-・ production2013

    • Author(s)
      Saga, K., Tamai, K., Yamasaki, T., and Kaneda, Y
    • Journal Title

      Clinical Cancer Research

      Volume: 19(3) Pages: 668-679

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma2012

    • Author(s)
      Kiyohara, E., Tamai, K., Katayama, I., Kaneda, Y.
    • Journal Title

      Gene Therapy

      Volume: 19 Pages: 731-41

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic administration of a novel immune-stimulatory pseudovirion suppresses lung metastatic melanoma by regionally enhancing IFN-gamma production2012

    • Author(s)
      Saga K.
    • Journal Title

      Clinical Cancer Research

      Volume: 19 Pages: 668-679

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combination of chemistry with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma2012

    • Author(s)
      Kiyohara E.
    • Journal Title

      Gene Therapy

      Volume: 19 Issue: 7 Pages: 731-741

    • DOI

      10.1038/gt.2011.123

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro investigation of efficient photodynamic therapy using a nonviral vector, hemagglutinating virus of Japan envelope2012

    • Author(s)
      Sakai M.
    • Journal Title

      J. Biomed. Opt.

      Volume: 17 Pages: 78002-78002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunogene therapy using immunomodulating HVJ-E vector augments anti-tumor effects in murine malignant glioma.2011

    • Author(s)
      Matsuda, M., Nimura, K., Shimbo, T., Hamasaki, T., Yamamoto, T., Matsumura, A. and Kaneda, Y
    • Journal Title

      J. Neuro-Oncology

      Volume: 103 Pages: 19-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma2011

    • Author(s)
      Kiyohara, E., Tamai, K., Katayama, I., Kaneda, Y.
    • Journal Title

      Gene Therapy

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methyl-beta cyclodextrin alters the production and infectivity of Sendai virus2011

    • Author(s)
      Fujita, H., Tamai, K., Kawachi, M., Saga, K., Yamasaki, T., Kaneda Y.
    • Journal Title

      Archives of Virology

      Volume: 156 Pages: 995-1005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of liposomes and pseudovirions with fusion activity for efficient gene delivery2011

    • Author(s)
      Yasufumi Kaneda
    • Journal Title

      Current Gene Therapy

      Volume: 11 Pages: 434-441

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunogene therapy using immunomodulating HVJ-E vector augments and-tumor effects in murine malignant glioma.2011

    • Author(s)
      Matsuda, M., Nimura, K., Shimbo, T., Hamasaki, T., Yamamoto, T., Matsumura, A., Kaneda, Y.
    • Journal Title

      J.Neuro-Oncology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Update on non-viral delivery methods for cancer therapy: possibilities of a drug delivery system with anticancer activities beyond delivery as a new therapeutic tool2010

    • Author(s)
      Kaneda, Y
    • Journal Title

      Expert Opinion on Drug Delivery

      Volume: 7 Pages: 773-780

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A non-replicating oncolytic vector as a novel therapeutic tool against cancer.2010

    • Author(s)
      Yasufumi Kaneda
    • Journal Title

      BMB Report

      Volume: 43 Pages: 773-780

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Update on non-viral delivery methods for cancer therapy : possibilities of a drug delivery system with anticancer activities beyond delivery as a new therapeutic tool.2010

    • Author(s)
      Yasufumi Kaneda
    • Journal Title

      Expert Opinion on Drug Delivery

      Volume: 7 Pages: 1079-1093

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規抗がん剤としての不活化ウイルス粒子のポテンシャル2012

    • Author(s)
      金田安史
    • Organizer
      日本脳神経学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2012-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規抗がん剤としての不活性化ウイルス粒子のポテンシャル2012

    • Author(s)
      金田安史
    • Organizer
      日本脳神経外科学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] HVJ envelope vectorの抗腫瘍効果の解明と高機能型ベクターの開発2011

    • Author(s)
      金田安史
    • Organizer
      日本生化学会大会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] HVJ envelope vectorの抗腫瘍効果の解明と高機能型ベクターの開発2011

    • Author(s)
      金田安史
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Efficient eradication of castration-resistant human prostate cancers by inactivated Sendai virus particle2011

    • Author(s)
      Hatano, K., Nakai, Y., Miyamoto, Y., Nonomura, N., Kaneda, Y.
    • Organizer
      第14回アメリカ遺伝子細胞治療学会
    • Place of Presentation
      Seattle (USA)
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌の分子治療法の現状と将来展望2010

    • Author(s)
      金田安史
    • Organizer
      日本中性子捕捉療法学会
    • Place of Presentation
      学習院大学
    • Year and Date
      2010-08-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌の分子治療法の現状と将来展望2010

    • Author(s)
      金田安史
    • Organizer
      第7回日本中性子捕捉療法学会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝子治療の過去・現在・未来2010

    • Author(s)
      金田安史
    • Organizer
      第109回日本皮膚科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Book] 遺伝子と医療2013

    • Author(s)
      金田安史
    • Total Pages
      230
    • Publisher
      丸善出版
    • Related Report
      2012 Final Research Report
  • [Book] Future directions for gene therapy2012

    • Author(s)
      Yasufumi Kaneda
    • Total Pages
      13
    • Publisher
      www.futuremedicine.com
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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