Development of cancer molecular therapeutics that targets telomere-regulating factors

• Project/Area Number: 22300341
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: SEIMIYA Hiroyuki 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 部長 (50280623)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: テロメア / テロメラーゼ / がん / 不死化 / 細胞老化 / 分子標的治療 / 染色体 / DNA損傷 / グアニン四重鎖 / 阻害剤

Research Abstract

This study aims to design a telomere-directed cancer therapy. As main results, we found that G-quadruplex ligands induce DNA damage and transcriptional aberration and inhibit growth of glioma stem cells. We also found that self-assembly of tankyrase, a positive regulator of telomere elongation represses its function. Furthermore, we found that cancer cells that exhibit low expression of telomere-related factors, WRN and POT1, are sensitive to anti-microtubule drugs. These results would be applicable to development of new cancer chemotherapy

Research Products

• [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds (2013)
  • Author(s): Ushijima, M., Mashima, T., Tomida, A., Dan, S., Saito, S., Furuno, A., Tsukahara, S., Seimiya, H., Yamori, T., Matsuura, M
  • Journal Title: Cancer Sci Volume: 104 Pages: 360-8
  • Peer Reviewed
• [Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact (2013)
  • Author(s): Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H
  • Journal Title: Am J Pathol Volume: 182 Pages: 1800-1810
  • Peer Reviewed
• [Journal Article] Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand (2013)
  • Author(s): Iida, K., Majima, S., Nakamura, T., Seimiya, H., Nagasawa, K
  • Journal Title: Molecules Volume: 18 Pages: 4328-4341
  • Peer Reviewed
• [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds. (2013)
  • Author(s): Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
  • Journal Title: Cancer Sci. Volume: 104(3) Issue: 3 Pages: 360-368
  • DOI: 10.1111/cas.12071
  • Peer Reviewed
• [Journal Article] Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. (2013)
  • Author(s): Iida, K.
  • Journal Title: Molecules Volume: 18 Issue: 4 Pages: 4328-4341
  • DOI: 10.3390/molecules18044328
  • Peer Reviewed
• [Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact (2013)
  • Author(s): Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
  • Journal Title: Am J Pathol. Volume: 182 Issue: 5 Pages: 1800-1810
  • DOI: 10.1016/j.ajpath.2013.01.048
  • Peer Reviewed
• [Journal Article] Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation (2012)
  • Author(s): Ha, G. H., Kim, H. S., Go, H., Lee, H., Seimiya, H., Chung, D. H., Lee, C. W
  • Journal Title: Cell Death Differ Volume: 19 Pages: 321-332
  • Peer Reviewed
• [Journal Article] Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb (2012)
  • Author(s): Miyazaki, T., Pan, Y., Joshi, K., Purohit, D., Hu, B., Demir, H., Mazumder, S., Okabe, S., Yamori, T.,Viapiano, M., Shin-ya, K., Seimiya, H., Nakano, I
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 1268-1280
  • Peer Reviewed
• [Journal Article] A caged ligand for a telomeric G-quadruplex (2012)
  • Author(s): Nakamura, T., Iida, K., Tera, M., Shin-ya, K., Seimiya, H., Nagasawa, K
  • Journal Title: Chembiochem Volume: 13 Pages: 774-777
  • Peer Reviewed
• [Journal Article] JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells (2012)
  • Author(s): Kawahara, T., Hosoya, T., Tsukamoto, M., Okabe, S., Yamamura, H., Hayakawa, M., Seimiya, H., Takagi, M., Shin-Ya, K
  • Journal Title: J Antibiot Volume: 65 Pages: 373-375
  • NAID: 10030955529
  • Peer Reviewed
• [Journal Article] et al., HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle (2012)
  • Author(s): Deardorff, M.A., Seimiya, H.
  • Journal Title: Nature Volume: 489 Pages: 313-317
  • Peer Reviewed
• [Journal Article] HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. (2012)
  • Author(s): Deardorff MA
  • Journal Title: Nature Volume: 489(7415) Issue: 7415 Pages: 313-7
  • DOI: 10.1038/nature11316
  • Peer Reviewed
• [Journal Article] Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation. (2012)
  • Author(s): Ha, G.H.
  • Journal Title: Cell Death Differ Volume: 19 Issue: 2 Pages: 321-332
  • DOI: 10.1038/cdd.2011.101
  • Peer Reviewed
• [Journal Article] JBIR-120: a new growth inhibitor of hormone-refractory prostate cancer cells. (2012)
  • Author(s): Kawahara, T.
  • Journal Title: J Antibiot Volume: 65 Issue: 7 Pages: 373-375
  • DOI: 10.1038/ja.2012.32
  • Peer Reviewed
• [Journal Article] A Caged Ligand for a Telomeric G-Quadruplex (2012)
  • Author(s): T.Nakamura, K.Iida, M.Tera, K.Shin-ya, H.Seimiya, K.Nagasawa
  • Journal Title: ChemBioChem Volume: Vol.13 Issue: 6 Pages: 774-777
  • DOI: 10.1002/cbic.201200013
  • Peer Reviewed
• [Journal Article] A caged ligand for a telomeric g-quadruplex (2012)
  • Author(s): Nakamura T
  • Journal Title: Chembiochem Volume: 13 Pages: 774-7
  • Peer Reviewed
• [Journal Article] Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb (2012)
  • Author(s): Miyazaki T
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 1268-80
  • Peer Reviewed
• [Journal Article] Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation (2012)
  • Author(s): Ha GH
  • Journal Title: Cell Death Differ Volume: 19 Pages: 321-32
  • Peer Reviewed
• [Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer (2011)
  • Author(s): Mashima, T., Okabe, S., Seimiya, H
  • Journal Title: Mol Cell Pharmacol Volume: 3 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Fission yeast pot1 and recQ helicase are required for efficient chromosome segregation (2011)
  • Author(s): Takahashi, K., Imano, R., Kibe, T., Seimiya, H., Muramatsu, Y., Kawabata, N., Tanaka, G., Matsumoto, Y., Hiromoto, T., Koizumi, Y., Nakazawa, N., Yanagida, M., Yukawa, M., Tsuchiya, E., Ueno, M
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 95-506
  • NAID: 120004205356
  • Peer Reviewed
• [Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication (2011)
  • Author(s): Mashima, T., Seimiya, H
  • Journal Title: Tumors of the Central Nervous System Volume: 1 Pages: 337-340
  • Peer Reviewed
• [Journal Article] Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb (2011)
  • Author(s): Miyazaki T, Pan Y, Joshi K, Purohit D, Hu B, Demir H, Mazumder S, Okabe S, Yamori T, Viapiano M, Shin-Ya K, Seimiya H, Nakano I
  • Journal Title: Clin Cancer Res Volume: 18(5) Issue: 5 Pages: 1268-1280
  • DOI: 10.1158/1078-0432.ccr-11-1795
  • Peer Reviewed
• [Journal Article] Fission yeast Pot1 and RecQ heticase are required for efficient chromosome segregation (2011)
  • Author(s): Takahashi K
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 495-506
  • Peer Reviewed
• [Journal Article] Fission yeast potl and recQ helicase are required for efficient chromosome segregation (2011)
  • Author(s): Takahashi, K.
  • Journal Title: Mol Cell Biol Volume: 31 Pages: 495-506
  • Peer Reviewed
• [Journal Article] Tankyrase-1 assembly to large protein complexes blocks its telomeric function (2011)
  • Author(s): Hatsugai, K.
  • Journal Title: FEBS Lett Volume: 584 Pages: 3885-3890
  • Peer Reviewed
• [Journal Article] Tankyrase-1 assembly to large protein complexes blocks its telomeric function (2010)
  • Author(s): Hatsugai, K., Ohishi, T., Sugimoto, Y., Seimiya, H
  • Journal Title: FEBS Lett Volume: 584 Pages: 3885-3890
  • Peer Reviewed
• [Journal Article] Expression of mutant RPA in human cancer cells causes telomere shortening (2010)
  • Author(s): Kobayashi, Y., Sato, K., Kibe, T., Seimiya, H., Nakamura, A., Yukawa, M., Tsuchiya, E., Ueno, M
  • Journal Title: Biosci Biotechnol Biochem Volume: 74 Pages: 382-385
  • NAID: 10027551727
  • Peer Reviewed
• [Journal Article] Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth (2010)
  • Author(s): Mashima, T., Okabe, S., Seimiya, H
  • Journal Title: Mol Pharmacol Volume: 78 Pages: 846-854
  • Peer Reviewed
• [Journal Article] Role of insulin-like growth factor binding protein 2 in lung adenocarcinoma: IGF-independent antiapoptotic effect via caspase-3 (2010)
  • Author(s): Migita, T., Narita, T., Asaka, R., Miyagi, E., Nagano, H., Nomura, K., Matsuura, M., Satoh, Y., Okumura, S., Nakagawa, K., Seimiya, H., Ishikawa, Y
  • Journal Title: Am J Pathol Volume: 176 Pages: 1756-1766
  • Peer Reviewed
• [Journal Article] TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression (2010)
  • Author(s): Ohishi, T., Hirota, T., Tsuruo, T., Seimiya, H
  • Journal Title: Cancer Res Volume: 70 Pages: 2041-2052
  • Peer Reviewed
• [Journal Article] Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells (2010)
  • Author(s): Seki, T., Yuasa, S., Oda, M., Egashira, T., Yae, K., Kusumoto, D., Nakata, H., Tohyama, S., Hashimoto, H., Kodaira, M., Okada, Y., Seimiya, H., Fusaki, N., Hasegawa, M., Fukuda, K
  • Journal Title: Cell Stem Cell Volume: 7 Pages: 11-14
  • Peer Reviewed
• [Journal Article] Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole (2010)
  • Author(s): Tera, M., Iida, K., Ikebukuro, K., Seimiya, H., Shin-Ya, K., Nagasawa, K
  • Journal Title: Org Biomol Chem Volume: 8 Pages: 2749-2755
  • Peer Reviewed
• [Journal Article] A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor (2010)
  • Author(s): Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H., Yoshida, M
  • Journal Title: Biochem Biophys Res Commun Volume: 394 Pages: 569-573
  • Peer Reviewed
• [Journal Article] Role of insulin-like growth factor binding protein 2 in lung adenocarcinoma : IGF-independent antiapoptotic effect via caspase-3 (2010)
  • Author(s): Migita, T.
  • Journal Title: Am J Pathol Volume: 176 Pages: 1756-1766
  • Peer Reviewed
• [Journal Article] Telomere length influences cancer cell differentiation in vivo
  • Author(s): Hirashima,K., Migita,T., Sato, S., Muramatsu, Y., Ishikawa,Y., Seimiya, H
  • Journal Title: Mol Cell Biol, in press
  • Peer Reviewed
• [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation (2013)
  • Author(s): Seimiya, H
  • Organizer: 1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
  • Place of Presentation: (東京)
• [Presentation] Targeting glioma stem cells by G-quadruplex ligands (2013)
  • Author(s): Seimiya, H
  • Organizer: 第9回日米合同癌会議
  • Place of Presentation: (Ninth AACR-JCA Joint Conference, Breakthroughs in Basic and Translational Cancer Research) (Hawaii, USA)
• [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation (2013)
  • Author(s): Seimiya, H.
  • Organizer: 1st International Symposium on Protein Modifications in Pathogenic Dysregulation of Signaling
  • Place of Presentation: 東京
• [Presentation] Targeting glioma stem cells by G-quadruplex ligands (2013)
  • Author(s): Seimiya, H.
  • Organizer: 9th AACR-JCA Joint Conference: Breakthroughs in Basic and Translational Cancer Research
  • Place of Presentation: Hawaii, USA
• [Presentation] ポリ(ADP-リボシル)化酵素タンキラーゼによる細胞制御と阻害剤開発 (2012)
  • Author(s): 清宮啓之
  • Organizer: 慶應義塾大学先端医科学研究所セミナー(招待講演)
  • Place of Presentation: (東京)
  • Year and Date: 2012-10-11
• [Presentation] テロメア動態のネットワーク解析と薬剤反応性研究への応用 (2012)
  • Author(s): 村松由起子
  • Organizer: 「修飾シグナル病」学術領域の新展開
  • Place of Presentation: 東大医科学研究所(東京都)
  • Year and Date: 2012-01-28
• [Presentation] テロメア長が腫瘍形態に及ぼす影響 (2012)
  • Author(s): 平島匡太郎
  • Organizer: 平成23年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 琵琶湖ホテル(滋賀県)
  • Year and Date: 2012-01-18
• [Presentation] Regulation of chromosome segregation by a telomeric protein (2012)
  • Author(s): Seimiya, H
  • Organizer: The 11th Korea-Japan-Germany Joint Symposium on Cancer and Ageing Research(招待講演)
  • Place of Presentation: (Gyeongju, Korea)
• [Presentation] Targeting glioma stem cells by G-quadruplex ligands (2012)
  • Author(s): Seimiya, H
  • Organizer: 第71回日本癌学会学術総会International Session(招待講演)
  • Place of Presentation: (札幌)
• [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation (2012)
  • Author(s): Seimiya, H
  • Organizer: EMBO Conference on Telomeres and the DNA Damage Response
  • Place of Presentation: (L'Isle sur la Sorgue, France)
• [Presentation] Targeting glioma stem cells by G-quadruplex ligands (2012)
  • Author(s): Seimiya, H
  • Organizer: 2nd Japanese-French Cancer Workshop(招待講演)
  • Place of Presentation: (鳴門)
• [Presentation] Regulation of chromosome segregation by a telomeric protein (2012)
  • Author(s): Seimiya, H.
  • Organizer: The 11th Korea-Japan-Germany Joint Symposium on Cancer and Ageing Research
  • Place of Presentation: Gyeongju, Korea
  • Invited
• [Presentation] 新薬の原石をもとめて ～抗がん剤・化合物スクリーニング～ (2012)
  • Author(s): Seimiya, H.
  • Organizer: 平成24年度がん若手研究者ワークショップ
  • Place of Presentation: 蓼科
  • Invited
• [Presentation] Targeting glioma stem cells by G-quadruplex ligands (2012)
  • Author(s): Seimiya, H.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] TRF1 regulates the microtubule-kinetochore attachment and contributes to proper chromosome segregation (2012)
  • Author(s): Seimiya, H.
  • Organizer: EMBO Conference on Telomeres and the DNA Damage Response
  • Place of Presentation: L’Isle sur la Sorgue, France
• [Presentation] Regulation of chromosome segregation by a telomeric protein (2012)
  • Author(s): Seimiya, H.
  • Organizer: The 2nd Japanese-French Cancer Workshop
  • Place of Presentation: 徳島
  • Invited
• [Presentation] テロメア長が腫瘍形態に及ぼす影響 (2011)
  • Author(s): 平島匡太郎
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-13
• [Presentation] Regulation of chromosome segregation by a telomeric protein TRF1 (2011)
  • Author(s): Seimiya, H
  • Organizer: 日仏がん研究ワークショップ(招待講演)
  • Place of Presentation: (フランス・モンペリエ)
  • Year and Date: 2011-11-22
• [Presentation] Regulation of chromosome segregation by a telomeric protein TRF1 (2011)
  • Author(s): 清宮啓之
  • Organizer: 日仏がん研究ワークショップ
  • Place of Presentation: Mercure Montpellier Centre(フランス・モンペリエ)(招待講演)
  • Year and Date: 2011-11-22
• [Presentation] Telomere fingerprinting for drug sensitivity studies and cancer cell biology (2011)
  • Author(s): Seimiya, H
  • Organizer: ニース大学招待セミナー(招待講演)
  • Place of Presentation: (フランス・ニース)
  • Year and Date: 2011-11-21
• [Presentation] Telomere fingerprinting for drug sensitivity studies and cancer cell biology (2011)
  • Author(s): 清宮啓之
  • Organizer: ニース大学招待セミナー
  • Place of Presentation: ニース大学(フランス・ニース)(招待講演)
  • Year and Date: 2011-11-21
• [Presentation] がん治療応用を目指したテロメア研究の現況 (2011)
  • Author(s): 清宮啓之
  • Organizer: 医薬ライセンシング協会 第236回月例会(招待講演)
  • Place of Presentation: (東京)
  • Year and Date: 2011-11-15
• [Presentation] がん治療応用を目指したテロメア研究の現況 (2011)
  • Author(s): 清宮啓之
  • Organizer: 医薬ライセンシング協会第236回月例会
  • Place of Presentation: 学士会館(東京都)(招待講演)
  • Year and Date: 2011-11-15
• [Presentation] Involvement of the telomeric protein TRF1 in regulation of chromosome segregation (2011)
  • Author(s): 大石智一
  • Organizer: 第15回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] ポリ(ADP-リボシル)化酵素タンキラーゼ1の新たな分子機能 (2011)
  • Author(s): 清宮啓之
  • Organizer: 第84回日本生化学会大会シンポジウム「ADP-リボシル化によるシグナル伝達制御」(招待講演)
  • Place of Presentation: (京都)
  • Year and Date: 2011-09-21
• [Presentation] ポリ(ADP-リボシル)化酵素タンキラーゼ1の新たな分子機能 (2011)
  • Author(s): 清宮啓之
  • Organizer: 第84回日本生化学会大会シンポジウム「ADP-リボシル化によるシグナル伝達制御」
  • Place of Presentation: 国立京都国際会館(京都府)(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] がんとは何でしょう? (2011)
  • Author(s): 清宮啓之
  • Organizer: 新学術領域研究「がん研究分野の特性等を踏まえた支援活動」青少年・市民公開講座～いま知っておきたい「がん」のこと～
  • Place of Presentation: 福島県立医科大学(福島県)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] テロメアを起点とした創薬シーズ開発と新たながん生物学研究への展開 (2011)
  • Author(s): 清宮啓之
  • Organizer: 愛媛大学 第4回分子病態医学セミナー(招待講演)
  • Place of Presentation: (松山)
  • Year and Date: 2011-09-07
• [Presentation] テロメアを起点とした創薬シーズ開発と新たながん生物学研究への展開 (2011)
  • Author(s): 清宮啓之
  • Organizer: 愛媛大学第4回分子病態医学セミナー
  • Place of Presentation: 愛媛大学(愛媛県)(招待講演)
  • Year and Date: 2011-09-07
• [Presentation] テロメア蛋白質TRF1の染色体分配への関与 (2011)
  • Author(s): 大石智一
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2011-06-24
• [Presentation] グアニン四重鎖を安定化するケージド低分子化合物の創製 (2011)
  • Author(s): 中村貴大
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2011-06-23
• [Presentation] テロメア維持の阻害が微小管阻害剤感受性を与える機構の解明 (2011)
  • Author(s): 高橋克典
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
  • Year and Date: 2011-03-26
• [Presentation] Telomere binding protein TRFI mediates mitotic abnormalities led by Aurora A overexpression (2011)
  • Author(s): Ohishi T.
  • Organizer: 第10回日韓がん老化合同シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-02-15
• [Presentation] Synthesis and evaluation of macrocyclic heptaoxazole compound as a fluorescent G-quadruplex binder (2011)
  • Author(s): Tera, M.
  • Organizer: 第10回日韓がん老化合同シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-02-15
• [Presentation] Visualization and detection of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole(7OTD) (2010)
  • Author(s): Tera, M.
  • Organizer: Pacifichem 2010
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-12-16
• [Presentation] Development of telomerase inhibitors and their application to anticancer therapeutics (2010)
  • Author(s): Seimiya, H.
  • Organizer: Pacifichem 2010
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2010-12-15
• [Presentation] テロメア長・テロメラーゼがin vivo腫瘍形態に及ぼす影響 (2010)
  • Author(s): 平島匡太郎
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] 細胞分裂の異常を媒介するテロメア蛋白質 (2010)
  • Author(s): 清宮啓之
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会・ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Telomeric protein TRFI regulates the microtubule function in mitosis (2010)
  • Author(s): Ohishi T.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] がん治療応用をめざしたテロメア研究の新展開 (2010)
  • Author(s): 清宮啓之
  • Organizer: 東京大学医科学研究所・学友会セミナー・GCOE特別セミナー
  • Place of Presentation: (東京)
  • Year and Date: 2010-07-26
• [Presentation] がん治療応用をめざしたテロメア研究の新展開 (2010)
  • Author(s): 清宮啓之
  • Organizer: 東京大学医科学研究所学友会セミナー・GCOE特別セミナー
  • Place of Presentation: 東京
  • Year and Date: 2010-07-26
• [Presentation] Aurora A過剰発現による細胞分裂異常はテロメア結合タンパク質TRF1によって媒介される (2010)
  • Author(s): 大石智一
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-08
• [Presentation] 細胞分裂の異常を媒介するテロメア蛋白質 (2010)
  • Author(s): 清宮啓之
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会・ワークショップ
  • Place of Presentation: (神戸)
• [Presentation] Development of telomerase inhibitors and their application to anticancer therapeutics (2010)
  • Author(s): Seimiya, H
  • Organizer: Pacifichem 2010
  • Place of Presentation: (Hawaii, USA)
• [Presentation] 分裂酵母を用いたタンキラーゼ1阻害剤のハイスループットスクリーニングシステムの構築 (2010)
  • Author(s): 八代田陽子
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京
• [Presentation] グアニン四重鎖を安定化する大環状ポリオキサゾール化合物の抗腫瘍活性に関する研究 (2010)
  • Author(s): 飯田圭介
  • Organizer: 第14回日本がん分子標的治療学会学術集会
  • Place of Presentation: 東京
• [Remarks]
  • URL: http://www.jfcr.or.jp/chemotherapy/department/molecular_biotherapy/index.html
• [Remarks] アウトリーチ活動・支援活動 清宮啓之, がんとは何でしょう? 新学術領域研究「がん研究分野の特性等を踏まえた支援活動」青少年・市民公開講座?いま知っておきたい「がん」のこと?(福島), 平成23年9月17日
• [Remarks] 清宮啓之, がん研究基礎セミナー「新薬の原石をもとめて ?抗がん剤・化合物スクリーニング?」, 平成24年度がん若手研究者ワークショップ(蓼科), 平成24年9月5-8日
• [Remarks]
  • URL: http://www.jfcr.or.jp/chemotherapy/department/molecular_biotherapy/index.html
• [Remarks]
  • URL: http://www.jfcr.or.jp/chemotherapy/department/molecular_biotherapy/index.html