Adaptive mechanisms of cancer cells to unique growth microenvironment and therapeutic targeting
| Project/Area Number |
22300342
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
TOMIDA Akihiro 公益財団法人がん研究会, がん化学療法センターゲノム研究部, 部長 (40251483)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | がん細胞 / 微小環境 / グルコース飢餓 / ストレス応答 / 分子標的治療 |
|---|
| Research Abstract |
In this study, we focused on the UPR, a cellular adaptive response to glucose deprivation, that is characteristically observed in tumor microenvironment. Through the mechanistic analyses of UPR-inhibitory compounds, we elucidated that mitochondria and translation control machinery play an important role in the UPR during glucose deprivation. By evaluating the antitumor effects of the compounds, we obtained fundamental information for the therapeutic targeting of the UPR
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-in duced cyto toxicity during glucose deprivation2012
Author(s)
Matsuo J, Tsukumo Y, Saito S, Tsukahara S, Sakurai J, Sato S, Kondo H, Ushijima M, Matsuura M, Watanabe T, Tomida A
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Journal Title
Mol Cancer Ther
Volume: 11(5)
Issue: 5
Pages: 1082-1091
DOI
Related Report
Peer Reviewed
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[Journal Article] Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity2010
Author(s)
Kim JY, Hwang JH, Cha MR, Yoon MY, Son ES, Tomida A, Ko B, Song SW, Shin-ya K, Hwang YI, Park HR
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Journal Title
J Cell Physiol
Volume: 224
Issue: 1
Pages: 33-40
DOI
Related Report
Peer Reviewed
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