• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of nuclear receptor-activating compounds produced By microalgae on aquatic animal

Research Project

Project/Area Number 22310020
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental impact assessment/Environmental policy
Research InstitutionUniversity of Tsukuba

Principal Investigator

KAYA Kunimitsu  筑波大学, 生命環境系, 教授 (40124341)

Co-Investigator(Kenkyū-buntansha) SHIRAISHI Fujio  国立環境研究所, 環境リスク研究センター, フェロー (30113476)
SANO Toharu  国立環境研究所, 環境リスク研究センター, 主任研究員 (10178808)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords7-hydroxy retinoic acid / RAR agonistic activity / Cyanobacteria / Teratogen / 7-Hydroxy retinoic acid / cis-trans isomerization / keto-enol tautomerism / teratogenic test / all-trans retinoic acid / zebrafish / cyanobacteria / photostability / medaka ER / yeast-two-hybrid assay / E2 / Planktothrix agardhii / warerblooms / Cylindrospermopsis raciborskii / nuclear receptors / RAR / Two-hybrid assay / Microcysits / spirulina / ATLA / UV-A
Research Abstract

A novel analogue of retinoic acid, 7-hydroxy retinoic acid, was found in waterbloom-forming cyanobacteria. The analogue had an agonistic activity against retinoic acid receptor (RAR) as a kind of nuclear receptors. The novel analogue was isolated from mass-cultured Spirulina sp.(TU-3).The analogue was found in all-tested strains of cyanobacteria. The analogue exist a mixture of four isomers by cis-trans isomerization including keto-enol tautomerism. The agonistic activity of the analogue against RAR was a half of all-trans retinoic acid (ATRA). The analogue was far-stable under UV-A compared with ATRA. The stability of 7-hydroxy retinoic acid under UV-A suggest that amphibians and fishes living in waterblooms occurring waters may be exposure, and give teratogenic effects.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] A novel retinoic acid analogue, 7-hydroxy retinoic acid, isolated from cyanobacteria2011

    • Author(s)
      Kaya K, Shiraishi F., Uchida H and Sano T
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1810 Issue: 4 Pages: 414-419

    • DOI

      10.1016/j.bbagen.2010.11.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel retinoic acid analogue, 7-hydroxy retinoic acid isolated from cyanobacteria2011

    • Author(s)
      Kaya, K, Shiraishi, F, Uchida H, Sano, T.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1810 Pages: 414-419

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Is 7-hydroxy retinoic acid of cyanobacteria an aquatic ecotoxin?2013

    • Author(s)
      Kaya, Kunimitsu
    • Organizer
      9th International Conference on Toxic Cyanobacteria
    • Place of Presentation
      Johannesburg, South Africa
    • Related Report
      2012 Annual Research Report
  • [Presentation] Is 7-hydroxy retinoic acid of cyanobacteria an aquatic ecotoxin?2012

    • Author(s)
      Kaya K, Shiraishi F, and Sano T
    • Organizer
      9^<th> International Conference on To xi c Cyanobacteria.
    • Place of Presentation
      Johannesburg, South Africa
    • Year and Date
      2012-08-12
    • Related Report
      2012 Final Research Report
  • [Presentation] A photostable retinoic acid analogue, 7-hydrioxy retinoic acid isolated from Spirulina and other cyanobacteria2012

    • Author(s)
      Kaya K, ShiraishiF, Sano T
    • Organizer
      8^<th> Asia-Pacific Conference on Algal Biotechnology
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2012-07-11
    • Related Report
      2012 Final Research Report
  • [Presentation] A photostable retinoic acid analogue, 7-hydroxy retinoic acid, isolated from Spirulina and other cyanobacteria2012

    • Author(s)
      Kaya, Kunimitsu
    • Organizer
      8th Asia-Pacific conference on Algal Biotechnology
    • Place of Presentation
      Adelaide, Australia
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi