| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
A novel analogue of retinoic acid, 7-hydroxy retinoic acid, was found in waterbloom-forming cyanobacteria. The analogue had an agonistic activity against retinoic acid receptor (RAR) as a kind of nuclear receptors. The novel analogue was isolated from mass-cultured Spirulina sp.(TU-3).The analogue was found in all-tested strains of cyanobacteria. The analogue exist a mixture of four isomers by cis-trans isomerization including keto-enol tautomerism. The agonistic activity of the analogue against RAR was a half of all-trans retinoic acid (ATRA). The analogue was far-stable under UV-A compared with ATRA. The stability of 7-hydroxy retinoic acid under UV-A suggest that amphibians and fishes living in waterblooms occurring waters may be exposure, and give teratogenic effects.
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