Regulatory mechanisms of translesion DNA synthesis
| Project/Area Number |
22310034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 修復 / 損傷乗り越えDNA複製 / DNA損傷 / DNA複製 / DNA修復 / タンパク質翻訳後修飾 / タンパク質間相互作用 / 損傷乗り越え複製 / 翻訳後修飾 / モノユビキチン化 / トレランス / DNAポリメラーゼ / 遺伝子 / 癌 / タンパク質 / ゲノム / 老化 / 放射線 |
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| Research Abstract |
Human DNA polymerase eta (Polη) is the responsible gene product of a cancer prone genetic disorder, xeroderma pigmentosum variant, catalyzes accurate and efficient translesion DNA synthesis, and prevents cell death and carcinogenesis induced by DNA damages. This project revealed that human Polηhas a unique structure to catalyze the accurate and efficient translesion DNA synthesis. This project also identified a novel mechanism of PCNA ubiquitylation which is crucial for regulation of translesion DNA synthesis and related mechanisms.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] NBS1 recruits RAD18 via a RAD6-like domain and regulates Polη-dependent translesion DNA synthesis.2011
Author(s)
Yanagihara H., Kobayashi J., Tateishi S., Kato A., Matsuura S., Tauchi H., Yamada K., Takwzawa J., Sugasawa K., Masutani C., Hanaoka F., Weemaes C.M., Mori T., Zou L., *Komatsu K.
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Journal Title
Mol. Cell
Volume: 43 (5)
Pages: 788-797
NAID
Related Report
Peer Reviewed
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[Journal Article] Characterization of a Y-family DNA polymerase eta from the eukaryotic themophile Alvinella pompejana2010
Author(s)
Kashiwagi S., Kuraoka I., Fujiwara Y., Hitomi K., Cheng Q.J., Fuss J.O., Shin D.S., Masutani C., Tainer J.A., Hanaoka F., Iwai S.
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Journal Title
J. Nucleic Acids
Pages: 701472-701472
Related Report
Peer Reviewed
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[Journal Article] Simultaneous disruption of two DNA polymerases, Polηand Polζ, in avian DT40 cells unmasks the role of Polηin cellular response to various DNA lesions.2010
Author(s)
Hirota K., Sonoda E., Kawamoto T., Motegi A., Masutani C., Hanaoka F., Szuts D., Iwai S., Sale J.E., Lehmann A., Takeda S.
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Journal Title
PLoS Genetics
Volume: 6(10)
Related Report
Peer Reviewed
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[Presentation] The ying and yang and human DNA polymerase eta in cancer avoidance2010
Author(s)
Biertumpfel C., Zhao Y., Kondo Y., Ramon-Maiques S., Gregory M., Lee J.Y., Masutani C., Lehmann A.R., Hanaoka F., Yang W.
Organizer
The 7th 3R (Replication, Recombination and Repair) Symposium
Place of Presentation
富山
Related Report
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[Presentation] Y-family DNA polymerases and nucleotide pool damage2010
Author(s)
Katafuchi A., Sassa A., Niimi N., Gruz P., Yamada M., Shimizu M., Fujimoto H., Masutani C., Hanaoka F., Ohta T., Nohmi T.
Organizer
第33回日本分子生物学会年会/第83回日本生化学会大会合同大会.
Place of Presentation
神戸
Related Report
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