| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
Human DNA polymerase eta (Polη) is the responsible gene product of a cancer prone genetic disorder, xeroderma pigmentosum variant, catalyzes accurate and efficient translesion DNA synthesis, and prevents cell death and carcinogenesis induced by DNA damages. This project revealed that human Polηhas a unique structure to catalyze the accurate and efficient translesion DNA synthesis. This project also identified a novel mechanism of PCNA ubiquitylation which is crucial for regulation of translesion DNA synthesis and related mechanisms.
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