| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
Reorganization of higher order nuclear structures has been thought to play an important role in DNA repair after ionizing radiation. However, the precise mechanism of radiation-induced reorganization of nuclear architecture is still unclear. In this study, we studied the molecular mechanisms involved in the formation of radiation induced higher order nuclear structures. We found that Matrin3 (MATR3), a nuclear structure-related protein, is involved in the regulation of the intra-nuclear dynamics of DNA repair protein RAD51. We also found that MATR3 plays a role in the regulation of the recombinational repair activity. These findings suggest the involvement of nuclear architecture in the regulation of DNA repair after ionizing radiation.
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