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Effects of chemical exposure on male reproductive organogenesis and functions

Research Project

Project/Area Number 22310040
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionThe University of Tokyo

Principal Investigator

YOSHINAGA Jun  東京大学, 大学院・新領域創成科学研究科, 准教授 (70222396)

Co-Investigator(Kenkyū-buntansha) HAYASHI Yutaro  名古屋市立大学, 大学院・医学研究科, 准教授 (40238134)
KOJIMA Yoshiyuki  名古屋市立大学, 大学院・医学研究科, 講師 (60305539)
Research Collaborator MIZUMOTO Yoshifumi  , 自衛隊中央病院産婦人科, 部長
TOKUOKA Susumu  , 徳岡レディースクリニック, 院長
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsフタル酸エステル / ピレスロイド / バイオマーカー / 肛門性器間距離 / 精液所見 / ピレスロイド系殺虫剤 / 胎児期曝露 / イソフラボン / 精液指標 / パラベン / 肛門性間距離
Research Abstract

Effects of environmental exposure to some selected chemicals on male reproductive organs and functions were examined in non-exposed general subjects. Urinary concentration of the target chemicals and/or their metabolites was used as a biomarker of exposure and anogenital distance (AGD) at birth and semen parameters was used for the assessment of effect on fetal and adult exposure to the target chemicals, respectively. In utero exposure to phthalate di(2-ethylhexyl) was found to shorten AGD of male newborn. Exposure to pyrethroid insecticides was found to decrease semen motility in male partners of infertile couples. These findings were assumed to be related to interference on testosterone action or production due to exposure to these chemicals at environmental levels.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (8 results)

  • [Journal Article] Urinary excretion of parabens in Japanese pregnant women.2013

    • Author(s)
      S. Shirai, Y. Suzuki, J. Yoshinaga, H. Shiraishi, Y. Mizumoto
    • Journal Title

      Reprod. Toxicol

      Volume: 35 Pages: 96-101

    • DOI

      10.1016/j.reprotox.2012.07.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Foetal exposure to phthalate esters and anogenital distance in male newborns2012

    • Author(s)
      Yayoi Suzuki, et al
    • Journal Title

      International Journal of Andrology

      Volume: 35(印刷中)(掲載確定) Issue: 3 Pages: 236-244

    • DOI

      10.1111/j.1365-2605.2011.01190.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of prolactin-induced protein with preputial development of hypospadias.2012

    • Author(s)
      S. Kurokawa, Y. Kojima, K. Mizuno, H.Kamisawa, K. Tozawa, K. Kohri, Y. Hayashi
    • Journal Title

      BJU Int.

      Volume: 109 Issue: 6 Pages: 926-32

    • DOI

      10.1111/j.1464-410x.2011.10467.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine disrupting chemicalsin urine of Japanese male partners of subfertile couples: A pilot study on exposure and semen quality.2012

    • Author(s)
      H. Toshima, Y. Suzuki, K. Imai, J.Yoshinaga, H. Shiraishi, Y. Mizumoto, S. Hatakeyama, C. Onohara, S. Tokuoka
    • Journal Title

      Int. J. Hyg. Environ. Health

      Volume: 215 Issue: 5 Pages: 502-506

    • DOI

      10.1016/j.ijheh.2011.09.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endocriue disrupting chemicals in urine of Japanese male partners of subfertile couples : A pilot study on exposure and semen quality2012

    • Author(s)
      Toshima H., et al.
    • Journal Title

      International Journal of Hygiene and Environmental Health

      Volume: 215(印刷中)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine assessment of prepubertal boys with a history of cryptorchidism and/or hypospadias: a pilot study.2011

    • Author(s)
      S. Iwatsuki, Y. Kojima, K. Mizuno, H. Kamisawa, Y. Umemoto, S. Sasaki, K. Kohri, Y. Hayashi
    • Journal Title

      J Urol.

      Volume: 185(6 Suppl) Pages: 2444-50

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to polycyclic aromatichydrocarbon and birth outcomes.2011

    • Author(s)
      M. Niwa, Y. Suzuki, J. Yoshinaga, C.Watanabe, Y. Mizumoto
    • Journal Title

      Polycyclic Aromatic Compounds

      Volume: 31 Pages: 16-27

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic pathway of external genitalia formation and molecular etiology of hypospadias.2011

    • Author(s)
      Kojima Y, Kohri K, Hayashi Y.
    • Journal Title

      J Pediatr Urol.

      Volume: 6 Pages: 346-354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to phthalate esters and PAHs and birth outcomes2010

    • Author(s)
      Y. Suzuki, M. Niwa, J. Yoshinaga, Y.Mizumoto, S. Serizawa, H. Shiraishi
    • Journal Title

      Environ. Int.

      Volume: 36 Issue: 7 Pages: 699-704

    • DOI

      10.1016/j.envint.2010.05.003

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 尿中代謝産物濃度を用いた日本人のイソフラボン曝露評価2012

    • Author(s)
      鈴木弥生、吉永淳
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都大学吉田キャンパス(京都府)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 尿中代謝産物濃度を用いた日本人のイソフラボン曝露評価2012

    • Author(s)
      鈴木弥生、吉永淳
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都大学吉田キャンパス百周年時計台記念館、京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Prenatal exposure to soy isoflavones and anogenital distance in male newborns"2012

    • Author(s)
      Y. Suzuki, J. Yoshinaga, Y.Mizumoto, S. Serizawa, H. Shiraishi
    • Organizer
      2010 Joint Conference of International Society of Exposure Science & International Society for Environmental Epidemiology
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] 異なる前処理による尿中ピレスロイド代謝産物濃度測定値の変動2011

    • Author(s)
      登島弘基、 吉永淳、白石寛明、伊藤由起、上島通浩、上山純
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      昭和大学旗の台キャンパス4号館、東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人男性におけるピレスロイド曝露と精液所見との関連2010

    • Author(s)
      登島弘基、吉永淳、水本賀文、白石寛明、小野原千恵、畠山将太、徳岡晋
    • Organizer
      環境ホルモン学会第13回研究発表会
    • Place of Presentation
      東京大学山上会館(東京)
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「パーソナルケア製品使用によるパラベン類経皮吸収率の推定」環境ホルモン学会2010

    • Author(s)
      白井さやか、吉永淳、白石寛明
    • Organizer
      第13回研究発表会
    • Place of Presentation
      東京大学山上会館、東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人男性のフタル酸エステル類曝露と精液パラメータの関連2010

    • Author(s)
      鈴木弥生、登島弘基、 吉永淳、水本賀文、白石寛明、小野原千恵、畠山将太、徳岡晋
    • Organizer
      環境ホルモン学会第13回研究発表会
    • Place of Presentation
      東京大学山上会館、東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人男性におけるピレスロイド曝露と精液所見との関連2010

    • Author(s)
      登島弘基、 吉永淳、水本賀文、白石寛明、小野原千恵、畠山将太、徳岡晋
    • Organizer
      環境ホルモン学会第13回研究発表会
    • Place of Presentation
      東京大学山上会館、東京
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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