| Co-Investigator(Kenkyū-buntansha) |
SKATA Shogo 広島大学, 大学院・総合科学研究科, 教授 (50153888)
KOTAKE Yaichirou 広島大学, 大学院・総合科学研究科, 准教授 (20335649)
ISHIDA Atsuhiko 広島大学, 大学院・総合科学研究科, 准教授 (90212886)
MUKUDA Takao 広島大学, 大学院・総合科学研究科, 助教 (60346335)
ISHIHARA Yasuhiro 広島大学, 大学院・総合科学研究科, 助教 (80435073)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Research Abstract |
Neurotoxic effect of methylmercury or tributyltin was attenuated by de novosynthesized estradiol in rat hippocampal organotypic slice culture. The self-protective function of the neurosteroid might be one of the possible mechanisms for the selective sensitivity of the brain to neurotoxicants. Neurotoxic mechanism of tributyltin, neuroprotective effect of progesterone and allopregnanolone, and distribution of steroids in rat brain were studied.
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