Protective effect of neurosteroids on developmental brains
| Project/Area Number |
22310041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
YAMAZAKI Takeshi 広島大学, 大学院・総合科学研究科, 教授 (30192397)
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| Co-Investigator(Kenkyū-buntansha) |
SKATA Shogo 広島大学, 大学院・総合科学研究科, 教授 (50153888)
KOTAKE Yaichirou 広島大学, 大学院・総合科学研究科, 准教授 (20335649)
ISHIDA Atsuhiko 広島大学, 大学院・総合科学研究科, 准教授 (90212886)
MUKUDA Takao 広島大学, 大学院・総合科学研究科, 助教 (60346335)
ISHIHARA Yasuhiro 広島大学, 大学院・総合科学研究科, 助教 (80435073)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 神経毒性 / ニューロステロイド / エストラジオール / 海馬 / メチル水銀 / トリブチルスズ / 神経保護作用 / プロゲステロン / トリメチルスズ |
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| Research Abstract |
Neurotoxic effect of methylmercury or tributyltin was attenuated by de novosynthesized estradiol in rat hippocampal organotypic slice culture. The self-protective function of the neurosteroid might be one of the possible mechanisms for the selective sensitivity of the brain to neurotoxicants. Neurotoxic mechanism of tributyltin, neuroprotective effect of progesterone and allopregnanolone, and distribution of steroids in rat brain were studied.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Endogenous synthesis of corticosteroids in the hippocampus2011
Author(s)
Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Barron A, Kimoto T, Kawato S
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Adrenocortical zonation in humans under normal and pathological conditions.2010
Author(s)
Nishimoto K, Nakagawa K, Li D, Kosaka T, Oya M, Mikami S, Shibata H, Itoh H, Mitani F, Yamazaki T, Ogishima T, Suematsu M, Mukai K
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Journal Title
J Clin Endocrinol Metab.
Volume: 95
Pages: 2296-2305
Related Report
Peer Reviewed
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[Journal Article] Adrenocortical Zonation in Humans under Normal and Pathological Conditions2010
Author(s)
Nishimoto K, Nakagawa K, Li D, Kosaka T, Oya M, Mikami S, Shibata H, Itoh H, Mitani F, Yamazaki T, Ogishima T, Suematsu M, Mukai K
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Journal Title
J Clin Endocrinol Metab
Volume: 95
Pages: 2296-2305
Related Report
Peer Reviewed
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