| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Research Abstract |
Intense pulse-laser Irradiation to suspended organic microcrystalline powder in water leads to its fragmentation into nanoparticles. This technique allows fabrication of pure organic nanoparticle colloids without any chemical additives. Here, we applied this technique to water-insoluble flavonoids which are a class of plant secondary metabolites, and succeeded in preparing stable nanoparticle colloids of flavones and isoflavones. We have demonstrated the toxicity assay for HeLa cells, and have discussed potential applications of the laser ablation method to new phamatical agents and drugs.
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