Regulation of gene expression by chromosome condensation protein, condensin
| Project/Area Number |
22310116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KIMURA Keiji 筑波大学, 生命環境系, 准教授 (50332268)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 遺伝子発現制御 / クロマチン / コンデンシン / 核小体 / 細胞周期 / リン酸化 / 染色体凝縮 / 細胞体凝縮 / 転写制御 / 染色体 |
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| Research Abstract |
ChIP assay indicated that both isoform of condensin (I and II) presented on the rDNA region in the interphase nucleolus. Knockdown of condensin (I or II) led to enhanced acetylation of histones in rRNA region, suggesting that condensin condenses interphase chromatin structures and suppresses gene expressions. We also found that dephosphorylation of condensin (I and II) by PP1 and PP2A at the exit of mitosis was important for dissociation of condensin from mitotic chromosomes.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Novel nucleolar pathway connecting intracellular energy status with p53 activation2011
Author(s)
Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, Yanagisawa J
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Journal Title
J. Biol. Chem.
Volume: 288
Pages: 20861-20869
Related Report
Peer Reviewed
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[Journal Article] Novel nucleolar pathway connecting intracellular energy status with p53 activation.2011
Author(s)
Kumazawa T, Nishimura K, Kuroda T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, & Yanagisawa J.
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Journal Title
J. Biol. Chem.
Volume: 288
Issue: 23
Pages: 20861-20869
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel nucleolar pathway connecting intracellular energy status with p53 activation2011
Author(s)
Kumazawa T, Nishimura K, Kuroda, T, Ono W, Yamaguchi C, Katagiri N, Tsuchiya M, Masumoto H, Nakajima Y, Murayama A, Kimura K, Yanagisawa J
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Journal Title
J.Biol.Chem
Volume: 286
Pages: 20861-20869
Related Report
Peer Reviewed
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[Journal Article] Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF52011
Author(s)
Nakajima Y, Osakabe A, Suzuki T, Kishimoto H, Kuroda T, Fujimura T, Homma Y, Murayama A, Kimura K, Inoue S, Yanagisawa J
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Journal Title
Science Signaling
Volume: 4
Related Report
Peer Reviewed
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[Journal Article] Estrogen inhibits transforming growth factor beta signaling by promoting Smad2/3 degradation2010
Author(s)
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J
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Journal Title
J.Biol.Chem
Volume: 285
Pages: 14747-14755
Related Report
Peer Reviewed
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[Presentation] The localization of condensin II is regulated by a non-catalytic action of PP2A2010
Author(s)
Takemoto, A., Maeshima, K, Ikehara, T., Hanaoka, R, Yanagisawa, J., Kimura, K.
Organizer
Cold Spring Harbor Symposium
Place of Presentation
Cold Spring Harbor, NY, USA
Year and Date
2010-06-04
Related Report
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