The mechanism of the molecular clock that controls developmental dynamics
| Project/Area Number |
22310126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
System genome science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
BESSHO Yasumasa 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (70261253)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Takaaki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (60403333)
NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKUMURA Yuichi 愛知県立大学, 情報科学部, 准教授 (50324968)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 発生 / 体節 / 形態形成 / 振動 / ロバスト性 / Notch シグナル / 生物時計 / 分節化 / 転写因子 / Notch / 時間制御 / マウス / FGF / 濃度勾配 |
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| Research Abstract |
The aim of this study is to understand the mechanism of dynamics in somite formation in vertebrate development and uncover the principle of pattern formation by using temporal periodicity. During somite formation, the expression of several genes oscillate in the presomitic mesoderm, thereby controlling the cyclic somite segmentation. Here, we demonstrate that the period of the oscillatory gene expression and somite segmentation is fine-tuned by the strength of Notch signaling. Moreover, we show a modulator molecule of Notch signaling is essential for the robustness of the oscillatory gene expression.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Sassone-Corsi P.Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT12013
Author(s)
Bellet MM, Nakahata Y, Boudjelal M,Watts E, Mossakowska DE, Edwards KA,Cervantes M, Astarita G, Loh C, Ellis JL,Vlasuk GP
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Journal Title
Proc. Natl. Acad. Sci.USA
Volume: 110
Issue: 9
Pages: 3333-3338
DOI
Related Report
Peer Reviewed
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[Journal Article] Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis2011
Author(s)
Matsui T, Thitamadee S, Murata T,Kakinuma H, Nabetani T, Hirabayashi Y,Hirate Y, Okamoto H, and Bessho Y
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 108
Issue: 24
Pages: 9881-9886
DOI
NAID
Related Report
Peer Reviewed
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