| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
In this study, we performed screening studies targeting TRAIL, Wnt, and Hedgehog signaling pathways which are related to mainly cancer diseases from the extracts of various natural resources as well as synthetic compounds library constructed in our group. As a result, we have isolated a number of bioactive natural products having effects on these signaling pathways and the molecular mechanisms of these active compounds were also investigated in this study.
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