| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
1）We showed that SO286 inhibited protein aggregation induced by MPP+ through lysosomal degradation pathway. We attempted to identify the target protein of SO286 responsible for the mechanism of SO286 inhibited the MPP+-induced dot formation and regulation
2）We report that 5-lipoxygenase (5-LOX) is activated and produces leukotriene C4(LTC4) in the process of cell migration, and 5-LOX inhibitors suppressed cell migration. Next, we identified cysteinyl leukotoriene receptor 1 (CysLT1) antagonist also block c
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