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Development of atmospheric-pressure laser desorption/ionization technique using nanoparticles and nanostructural surfaces

Research Project

Project/Area Number 22350040
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Analytical chemistry
Research InstitutionKansai University

Principal Investigator

ARAKAWA Ryuichi  関西大学, 化学生命工学部, 教授 (00127177)

Co-Investigator(Kenkyū-buntansha) KAWASAKI Hideya  関西大学, 化学生命工学部, 教授 (50322285)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsナノ粒子 / レーザー脱離イオン化 / SALDI-MS / アフィニテーSALDI-MS / MSイメージング / 局在表面プラズモン共鳴 / 白金ナノ粒子 / アミノ酸 / 白金ナノフラワー / レーザー脱離イオン化法 / 大気圧MALDI-MS / 磁性ナノ粒子 / 大気圧SALDI-MS / 質量分析イメージング / 白金スパッタ蒸着 / 添加剤 / 表面支援レーザー脱離イオン化法 / 表面プラズモン共鳴センシング / PFOA / LSPR / 白金粒子担持シリコン基板 / 置換メッキ法
Research Abstract

Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using nanoparticles and nanostructured surfaces, as compared to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using organic matrices, affords low-noise background (<500 Da). In this study, new atmospheric pressure(AP)-SALDI-MS was developed to achieve easily high-throughput analysis for low molecular weight compounds such as pollutants in environment, pharmaceutical products, and industry materials. Novel nanostructured surfaces and nanoparticle aggregates were designed to study effectiveness on AP-SALDI. The ionization mechanism of AP-SALDI is elucidated, compared with vacuum-SALDI. We could propose three new MS applications; 1) a complementary analytical methodology combining localized surface plasmon resonance (LSPR) sensing with SALDI-MS, 2) affinity SALDI-MS using magnetic nanoparticle, and 3) platinum vapor deposition SALD-MS imaging for small molecules.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (41 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (15 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Laser Desorption/Ionization Mass Spectrometry (LDI-MS) of Lipids with Iron Oxide Nanoparticle-Coated Targets2014

    • Author(s)
      M. Kusano, S. Kawabata, Y. Tamura, D. Mizoguchi, M. Murouchi, H. Kawasaki, R. Arakawa, and K. Tanaka
    • Journal Title

      Mass Spectrometry

      Volume: 3 Issue: 1 Pages: A0026-A0026

    • DOI

      10.5702/massspectrometry.A0026

    • NAID

      130003398583

    • ISSN
      2186-5116, 2187-137X
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein-modified silver nanoplates for the complementary analytical method of localised surface plasmon resonance and matrix assisted laser desorption/ionisation mass spectrometry2013

    • Author(s)
      M. Inuta, R. Arakawa, and H. Kawasaki
    • Journal Title

      Analytical Methods

      Volume: 5 Issue: 19 Pages: 5031-5036

    • DOI

      10.1039/c3ay40708j

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A thiophene-containing compound as a matrix for matrix-assisted laser desorption/ionization mass spectrometry and the electrical conductivity of matrix crystals2013

    • Author(s)
      Yasuda, T. Ishimaru, S. Nishihara, M. Sakai, H. Kawasaki, R. Arakawa and Y. Shigeri
    • Journal Title

      Eur. J. Mass Spectrom.

      Volume: 19 Issue: 1 Pages: 29-37

    • DOI

      10.1255/ejms.1215

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suitability of GaP nanoparticles as a surface- assisted laser desorption/ionization mass spectroscopy. Inorganic matrix and their soft ionization ability2013

    • Author(s)
      T. Yonezawa, H. Tsukamoto, S. Hayashi, Y. Myojin, H. Kawasaki, and R. Arakawa
    • Journal Title

      Analyst

      Volume: 138 Issue: 4 Pages: 995-999

    • DOI

      10.1039/c2an36738f

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Desorption/ionization efficiency of common amino acids in surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) with nanostructured platinum2013

    • Author(s)
      S. Nitta, H. Kawasaki, T. Suganuma, Y. Shigeri, and R. Arakawa
    • Journal Title

      J. Phys. Chem. C

      Volume: 117 Issue: 1 Pages: 238-245

    • DOI

      10.1021/jp308380z

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New matrix of MALDI-TOF MS for the analysis of thiolate-protected gold clusters2012

    • Author(s)
      H. Kouchi, H. Kawasaki and R. Arakawa
    • Journal Title

      Anal. Methods

      Volume: 4 Issue: 11 Pages: 3600-3603

    • DOI

      10.1039/c2ay26013a

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functionalized graphene-coated cobalt nanoparticles for highly efficient surface-assisted laser desorption/ionization mass spectrometry analysis2012

    • Author(s)
      H. Kawasaki, K. Nakai, R. Arakawa, E. K. Athanassiou, R. N. Grass, and W. J. Stark
    • Journal Title

      Anal. Chem.

      Volume: 84 Issue: 21 Pages: 9268-9275

    • DOI

      10.1021/ac302004g

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Serum Albumin-modified Fe<sub>3</sub>O<sub>4</sub> Magnetic Nanoparticles for Affinity-SALDI-MS of Small-Molecule Drugs in Biological Liquids2012

    • Author(s)
      Y. Iwaki, H. Kawasaki, and R. Arakawa
    • Journal Title

      Analytical Sciences

      Volume: 28 Issue: 9 Pages: 893-900

    • DOI

      10.2116/analsci.28.893

    • NAID

      130004442140

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platinum vapor deposition-assisted laser desorption/ionization for imaging mass spectrometry of small molecules2012

    • Author(s)
      H. Kawasaki, T. Ozawa, H. Hisatomi, and R. Arakawa
    • Journal Title

      Rapid Comm. Mass Spectrom.

      Volume: 26 Issue: 16 Pages: 1849-1858

    • DOI

      10.1002/rcm.6301

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desorption/Ionization Efficiency of Peptides Containing Disulfide Bonds in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry2012

    • Author(s)
      Y. Shigeri, S. Inazumi, Y. Hagihara, A. Yasuda, H. Kawasaki, R. Arakawa and M. Nakata
    • Journal Title

      Analytical Sciences

      Volume: 28 Issue: 3 Pages: 295-295

    • DOI

      10.2116/analsci.28.295

    • NAID

      130004442128

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] N,N-Dimethylformamide-Stabilized Gold Nanoclusters as a Catalyst for the Reduction of 4-Nitrophenol2012

    • Author(s)
      H. Yamamoto, H. Yano, H. Kouchi, Y. Obora, R. Arakawa, and H. Kawasaki
    • Journal Title

      Nanoscale

      Volume: 4 Issue: 14 Pages: 4148-4154

    • DOI

      10.1039/c2nr30222e

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Serum Albumin-Modified Fe3O4 Magnetic Nanoparticles for Affinity-SALDI-MS of Small-Molecule Drugs in Biological Liquid2012

    • Author(s)
      Y. Iwaki, H. Kawasaki, and R. Arakawa
    • Journal Title

      Anal. Sci.

      Volume: 28 Pages: 893-900

    • NAID

      130004442140

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of thermally annealed multilayer gold nanoparticle films in combination analysis of localized surface plasmon resonance sensing and MALDI mass spectrometry2011

    • Author(s)
      M. Inuta, R. Arakawa, and H. Kawasaki
    • Journal Title

      Analyst

      Volume: 136 Issue: 6 Pages: 1167-1176

    • DOI

      10.1039/c0an00826e

    • NAID

      120005686475

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microwave-assisted polyol synthesis of copper nanocrystals without using additional protective agents2011

    • Author(s)
      H.Kawasaki, Y.Kosaka, Y.Myoujin, T.Narushima, T.Yonezawa, R.Arakawa
    • Journal Title

      Chem.Commun.

      Volume: 47 Pages: 7740-7742

    • NAID

      120005686541

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trypsin-Stabilized Fluorescent Gold Nanocluster for Sensitive and Selective Hg2+ Detection2011

    • Author(s)
      H.Kawasaki, K.Yoshimura, K.Hamaguchi, R.Arakawa
    • Journal Title

      Anal.Sci.

      Volume: 27 Pages: 591-596

    • NAID

      10028289091

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of crystalline forms of titania on desorption/ionization efficiency in titania-based surface-assisted laser desorption/ionization mass spectrometry2010

    • Author(s)
      H. Kawasaki, K. Okumura, and R. Arakawa
    • Journal Title

      J. Mass Spectrom. Soc. Jpn.

      Volume: 58 Pages: 221-228

    • NAID

      10027692817

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of an antioxidant additive in insoluble plastics by surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS using TiO2 nanoparticles2010

    • Author(s)
      Osaka, K. Okumura, N. Miyake, T. Watanabe, K. Nozaki, H. Kawasaki, and R. Arakawa
    • Journal Title

      J. Mass Spectrom. Soc. Jpn.

      Volume: 58(4) Pages: 123-127

    • NAID

      10026518008

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platinum nanoflowers on scratched silicon by galvanic displacement for an effective SALDI substrate2010

    • Author(s)
      H. Kawasaki, T. Yao, T. Suganuma, K. Okumura, Y. Iwaki, T. Yonezawa, T. Kikuchi, and R. Arakawa
    • Journal Title

      Chem. Eur. J.

      Volume: 16 Issue: 35 Pages: 10832-10843

    • DOI

      10.1002/chem.201001038

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of platinum particle deposition on silicon surfaces for surface-assisted laser desorption/ionization mass spectrometry of peptides2010

    • Author(s)
      T. Yao, H. Kawasaki, T. Watanabe, and R. Arakawa
    • Journal Title

      Int. J. Mass Spectrom.

      Volume: 291 Pages: 145-151

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of platinum particle deposition on silicon surfaces for surface-assisted laser desorption/ionization mass spectrometry of peptides2010

    • Author(s)
      T.Yao, H.Kawasaki, T.Watanabe, R.Arakawa
    • Journal Title

      Int.J.Mass Spectrom.

      Volume: 291 Pages: 145-151

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platinum nanoflowers on scratched silicon by galvanic displacement for an effective SALDI substrate2010

    • Author(s)
      H.Kawasaki, T.Yao, T.Suganuma, K.Okumura, Y.Iwaki, T.Yonezawa, T.Kikuchi, R.Arakawa
    • Journal Title

      Chem.Eur.J.

      Volume: 16 Pages: 10832-10843

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stability of the DMF-protected Au nanoclusters : photochemical, dispersion, and thermal properties2010

    • Author(s)
      H.Kawasaki, H.Yamamoto, H.Fujimori, R.Arakawa, M.Inada, Y.Iwasaki
    • Journal Title

      Langmuir

      Volume: 26 Pages: 5926-5933

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functionalized graphene-coated cobalt nanoparticles as the matrix and magnetic separation for highly efficient SALDI-MS analysis2013

    • Author(s)
      K. Nakaia, H. Kawasaki, R. Arakawa, E. K. Athanassiou, R. N. Grass, and W. J. Stark
    • Organizer
      the 4th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Taipei( 台湾 )
    • Related Report
      2013 Final Research Report
  • [Presentation] A new matrix of MALDI-TOF MS for the analysis of thiolate-protected gold clusters2013

    • Author(s)
      H. Kouchi, H. Kawasaki, and R. Arakawa
    • Organizer
      the 4th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Taipei( 台湾 )
    • Related Report
      2013 Final Research Report
  • [Presentation] Desorption/ionization efficiency of the 20 common amino acids in SALDI-MS with platinum nanoflowers on siliconsubstrate2013

    • Author(s)
      Syuhei Nitta, Hideya Kawasaki, Takashi Suganuma, Yasushi Shigeri, and Ryuichi Arakawa
    • Organizer
      the 6th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Taipei International Convention Center (台湾)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A new matrix of MALDI-TOF MS for the analysis of thiolate-protected gold clusters2013

    • Author(s)
      Haruki Kouchi, Hidey Kawasaki and Ryuichi Arakawa
    • Organizer
      the 6th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Taipei International Convention Center (台湾)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functionalized graphene-coated cobalt nanoparticles as the matrix and magnetic separation for highly efficient SALDI-MS analysis2013

    • Author(s)
      K. Nakai, H. Kawasaki, R. Arakawa, E. K. Athanassiou, R. N. Grass and W. J. Stark
    • Organizer
      the 6th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Taipei International Convention Center (台湾)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 磁性炭化コバルトナノ粒子を用いた有機フッ素化合物のアフィニティSALDI-MS2013

    • Author(s)
      中井佳祐, 川崎英也, 荒川隆一,E. K. Athanassiou, R. N. Grass and W. J. Stark
    • Organizer
      第61回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場 エポカルつくば(茨城)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pt蒸着支援脱離イオン化を用いた葉およびポリマー表面のMSイメージング解析2013

    • Author(s)
      小澤智行, 川崎英也, 荒川隆一
    • Organizer
      第61回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場 エポカルつくば(茨城)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Efficiency of the 20 common amino acids in SALDI-MS with platinum nanoflowers on silicon substrate2012

    • Author(s)
      S. Nitta, H. Kawasaki, and R. Arakawa
    • Organizer
      International Mass Spectrometry Conference
    • Place of Presentation
      国立京都国際会館 ( 京都 )
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of biodegradation products of highly fluorinated products using (two-dimensional) liquid chromatograph coupled with high-resolution mass spectrometer2012

    • Author(s)
      A. Yamamoto, H. Hisatomi, T. Tojo, S. Takemine, D. Ono, M. Kitagawa, H. Kawasaki, and R. Arakawa
    • Organizer
      32nd International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      Queensland(Australia)
    • Related Report
      2013 Final Research Report
  • [Presentation] Platinum Vapor deposition-assisted laser desorption/ ionization for imaging mass spectrometry of small molecules2012

    • Author(s)
      H. Kawasaki, T. Ozawa, H. Hisatomi, T. Higashiisokawa, and R. Arakawa
    • Organizer
      60th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Vancouver(Canada)
    • Related Report
      2013 Final Research Report
  • [Presentation] Platinum Vapor Deposition-Assisted Laser Desorption/Ionization for Imaging Mass Spectrometry of Small Molecules2012

    • Author(s)
      Hideya Kawasaki; Tomoyuki Ozawa; Hirotaka Hisatomi; Tetsuro Higashiisokawa; (Ryuichi Arakawa)
    • Organizer
      60th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Vancouver Convention Centre (カナダ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functionalized Carbon-Coated Iron Nanoparticles as the Matrix and Magnetic Separation for Highly Efficient SALDI MS analysis2012

    • Author(s)
      K. Nakai, H. Kawasaki, (R. Arakawa), E. K. Athanassiou, R. N. Grass and W. J. Stark
    • Organizer
      IACIS (International Association of Colloid and Interface Scientists)2012
    • Place of Presentation
      仙台国際センター
    • Related Report
      2012 Annual Research Report
  • [Presentation] チオール保護金クラスターのMALDI-MSを用いたマトリックスの検討2012

    • Author(s)
      胡内春輝・川崎英也・(荒川隆一)
    • Organizer
      ナノ学会第10回大会
    • Place of Presentation
      大阪大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ESIに近い大気圧マトリックス支援レーザー脱離イオン化(AP-MALDI)の特性2011

    • Author(s)
      高岡真也・川崎英也・木内正人・荒川隆一
    • Organizer
      第59回質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Platinum nanoflowers from galvanic displacement on scratched silicon as an effective SALDI substrate2010

    • Author(s)
      H.Kawasaki
    • Organizer
      アジアオセアニア質量分析学会
    • Place of Presentation
      つくば国際会議場(招待講演)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Book] 現代質量分析学2012

    • Author(s)
      荒川隆一
    • Publisher
      化学同人
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.kikibun.com/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.chemmater.kansai-u.ac.jp/kiki/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.chemmater.kansai-u.ac.jp/kiki/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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