| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Research Abstract |
Organofluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Among them, trifluoromethylated aromatic compounds (Ar-CF3) are the substances of considerable interest in various industrial fields. Owing to the increasing demands for fluoroaromatics, new methodologies for aromatic trifluoromethylation have been required from the viewpoints of cost, simplicity, efficiency, versatility, and environmental benignity including a catalytic process. We have succeeded in the development of a catalytic procedure for aromatic trifluoromethylation by the use of trifluoroacetaldehyde hemiaminal derivatives as readily available cross-coupling partners. Furthermore, we have developed reaction sequences leading to efficient synthesis of difluoromethylated aromatics (Ar-CF2H) and monofluoromethylated aromatics (Ar-CFH2) via 2-aryl-2,2-difluoroacetates.
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