| Budget Amount *help |
¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Research Abstract |
In the present project, we successfully synthesized an aliphatic polyester dendrimer using AB2-type building blocks prepared by Michael addition of denzyl acetoacetate to t-butyl acrylate, followed by reduction and by deprotection of the t-butyl groups. The aliphatic polyester dendrimer is a candidate of smart nano-materials having controlled degradability and release function of low-molecular-weight compounds.
We also syntesized a new type of thermoresponsive star-type dendrimers having oligo(2-isopropyl-2-oxazoline) side chains and oligo(2-alkyl-2-oxazoline) terpolymer side chains, by precision polymer syntheses. Lower critical solution temperatures (LCSTs) and release profiles of the loaded low-molecular-weight compounds of the resulting star-type dendrimers are successfully controlled with changing the chemical structure, especially the arm structure. These star-type dendrimers are useful functional nano-materials in biochemical and biomedical fields.
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