| Project/Area Number |
22350053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
ANNAKA Masahiko 九州大学, 大学院・理学研究院, 教授 (40282446)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Toyoaki 奈良県立医科大学, 医学部, 准教授 (10238959)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 生体関連高分子 / 高分子ゲル / 有機-無機複合体 / 眼内レンズ / 調節 / 硝子体 / 加齢効果 / コラーゲン / 架橋構造 / マイクロレオロジー / 動的光散乱 / バイオハイドロゲル / 人工硝子体 / レオロジー / 中性子小角散乱 / 光学特性 / インプラント / 細胞毒性 / ヒアルロン酸 / 塩効果 / 相 / 臨界現象 |
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| Research Abstract |
We focus on the development of a novel injectable accommodative lens for intraocular applications, which is based on a thermosensitive hydrophobically-modified poly(ethylene glycol) containing hydrophilized silica nanoparticles. By injection of elastic polymers into the capsular bag of the eye as a fluid, body temperature transforms the polymer into optically clear gel that has the shape of a full-sized biconvex and completely fills the capsular bag. The gel does not leak and entirely cohesive. Under the condition of uniform distribution of silica nanoparticles with small size (2-5 nm) in the gel matrix, an increase in refractive index up to 0.0667 were obtained for nanocomposite compared with native gel matrix without an increase in turbidity. This composite system could be formulated to match the modulus and the refractive index of the natural lens (~1.411). The potential benefits of a full-sized, flexible accommodating lens system go beyond providing the accommodation lost with age. In fillingthe capsule, it might more closely resemble the action of the young, natural lens, eliminating the possibility of any intracapsular space for cell growth. The obtained results indicate that the amphiphilic polymer studied here has potential as a biomaterial suitable not only for long-term accommodative intraocular lens, but other biomedical field
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