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Structure elucidation of human telomeric DNA and RNA in cells by chemical approach and its application

Research Project

Project/Area Number 22350071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemistry related to living body
Research InstitutionUniversity of Miyazaki

Principal Investigator

XU Yan  宮崎大学, 医学部, 准教授 (40506763)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Keywordsテロメア DNA / ヒトテロメア RNA / 四重鎖構造 / 化学的アプローチ / 抗がん分子 / 核酸 / 生体分子 / テロメア / ヒトテロメアDNA / ヒトテロメアRNA
Research Abstract

The researches focus on (1) Understanding the structures and functions of human telomere DNA and RNA by chemical approaches, (2) Developing various chemical methods to targeting human telomeres and telomerase for t he treatment of cancer.The NMR showed that human telomere RNA forms a parallel G - quadruplex structure (J. Am. Chem. Soc. 132,7231, 2010.). Using a light - switching probe, we found that human telomere RNA forms a parallel G - quadruplex structure in living ce lls, providing the in vivo evidence for the presence of the G - quadruplex in human (Proc. Natl. Acad. Sci. USA. 107, 14579, 2010.). Furthermore, we demonstrated that small RNA - stabilized mRNA structures inhibit the translation in human cells. We also succes sfully detected the biomolecules by using DNA Nanomechan of telomere G- quadruplex structure (Nature Communcations 2011 2:449doi:10.1038/ncomms 1452 .).We developed a method for detection of individual telomere lengths (DITL) that uses a chemistry- based approac … More h that accurately measures the telomere lengths from individual chromosomes (J. Am. Chem. Soc. 135, 14, 2013.). We have used a model system to provide evidence about the formation of G - quadruplex structures involving telomeric DNA and RNA sequences t hat have the potential to provide a protective capping structure for telomere ends (J. Biol. Chem. 287, 41787, 2012.) .We developed a small 6- mer oligonucleotide with a photo - cross - linking reagent to cause efficient photo - cross - linking to human telomere D NA upon light irradiation( J. Am. Chem. Soc. 132, 631, 2010. ). We reported the first example of enantioselective recognition of quadruplex DNA by a chiral cyclic helicene ( J. Am. Chem. Soc. 132, 3778, 2010. ) . Furthermore, we demonstrated that a single peptide nucleic acid (PNA) effe ctively targets the G- rich region in double - stranded DNA through formation of a PNA/DNA hybrid G- quadruplex (Angew. Chem. Int. Ed. 51, 7198, 2012) .We also published three review papers about the researches (Chem. Soc. Rev. 2011, 40, 2719; Methods 57, 100, 2012;Curr. Pharm. Des. 18,2096,2012.) . Less

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (60 results)

All 2013 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (37 results) Remarks (4 results)

  • [Journal Article] Evidence for G-quadruplex DNA in human cells2013

    • Author(s)
      Y. Xu and M. Komiyama
    • Journal Title

      Chembiochem.

      Volume: 14 Issue: 8 Pages: 927-928

    • DOI

      10.1002/cbic.201300157

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Chemistry-Based Method to Detect Individual Telomere Lengths at a Single Chromosome Terminus2013

    • Author(s)
      T. Ishizuka, Y. Xu, and M. Komiyama
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 1 Pages: 14-17

    • DOI

      10.1021/ja308481c

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oligonucleotide Models of Telomeric DNA and RNA Form a Hybrid G-quadruplex Structure as a Potential Component of Telomeres2012

    • Author(s)
      Yan Xu, Takumi Ishizuka, Jie Yang, Kenichiro Ito, Hitoshi Katada, Makoto Komiyama, Tetsuya Hayashi
    • Journal Title

      J. Bio. Chem.

      Volume: Vol. 287 Issue: 50 Pages: 41787-41796

    • DOI

      10.1074/jbc.m112.342030

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] G-rich Sequence-specific Recognition and Scission of Human Genome by PNA/DNA Hybrid G-quadruplex Formation2012

    • Author(s)
      Takumi Ishizuka, Makoto Komiyama, Yan Xu
    • Journal Title

      Angew. Chem., Int. Ed.

      Volume: Vol. 51 Issue: 29 Pages: 7198-7202

    • DOI

      10.1002/anie.201201176

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human Telomere RNA: A Potential Target for Ligand Recognition2012

    • Author(s)
      YAN XU
    • Journal Title

      Current Pharmaceutical Design

      Volume: Vol.18 Issue: 14 Pages: 2096-2101

    • DOI

      10.2174/138161212799958378

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SWI/SNF-mediated chromatin remodeling induces Z-DNA formation on a nucleosome2012

    • Author(s)
      N. Mulholland、YAN XU、H. Sugiyama 、K. Zhao
    • Journal Title

      Cell & Bioscience

      Volume: Vol.2 Issue: 1

    • DOI

      10.1186/2045-3701-2-3

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanomechanical DNA origami 'single-molecule beacons' directly imaged by atomic force microscopy2012

    • Author(s)
      Akinori Kuzuya
    • Journal Title

      Nature Communications

      Volume: 1 Issue: 1 Pages: 449-449

    • DOI

      10.1038/ncomms1452

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure, function and targeting of human telomere RNA2012

    • Author(s)
      Y. Xu and M. Komiyama
    • Journal Title

      Methods

      Volume: 57 Issue: 1 Pages: 100-105

    • DOI

      10.1016/j.ymeth.2012.02.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human telomere RNA : a potential target for ligand recognition2012

    • Author(s)
      徐岩(YAN XU)
    • Journal Title

      Current Pharmaceutical Design

      Volume: Vol18 Pages: 2096-2101

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of translation by small RNA-stabilized mRNA structures in human cells2011

    • Author(s)
      K. Ito、S. Go、M. Komiyama、YAN XU
    • Journal Title

      J. Am. Chem. Soc

      Volume: Vol.133 Issue: 47 Pages: 19153-19159

    • DOI

      10.1021/ja206353c

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA2011

    • Author(s)
      YAN XU
    • Journal Title

      Chemical Society Reviews

      Volume: Vol.40 Issue: 5 Pages: 2719-2740

    • DOI

      10.1039/c0cs00134a

    • Related Report
      2012 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomeric Repeat-Containing RNA Structure in Living Cells2010

    • Author(s)
      YAN XU、 Y. Suzuki、 K. Ito、 M. Komiyama
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: Vol.107 Issue: 33 Pages: 14579-14584

    • DOI

      10.1073/pnas.1001177107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A U-Tetrad Stabilizes Human Telomeric RNA G-Quadruplex Structure2010

    • Author(s)
      YAN XU 、T. Ishizuka 、T. Kimura 、M. Komiyama
    • Journal Title

      J. Am. Chem. Soc

      Volume: Vol.132 Issue: 21 Pages: 7231-7233

    • DOI

      10.1021/ja909708a

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Chiral Wedge Molecule Inhibits Telomerase Activity2010

    • Author(s)
      K. Shinohara、Y. Sannohe、S. Kaieda、K.Tanaka、 H. Osuga、 H.Tahara、 YAN XU、T. Kawase、T. Bando、H. Sugiyama
    • Journal Title

      J. Am. Chem. Soc.

      Volume: Vol.132 Issue: 11 Pages: 3778-3782

    • DOI

      10.1021/ja908897j

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 6-mer Photocontrolled Oligonucleotide as an Effective Telomerase Inhibitor2010

    • Author(s)
      YAN XU、 K. Ito、 Y. Suzuki、 M. Komiyama
    • Journal Title

      J. Am. Chem. Soc

      Volume: Vol.132 Issue: 2 Pages: 631-637

    • DOI

      10.1021/ja907417r

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A 6-mer Photocontrolled Oligonucleotide as an Effective Telomerase Inhibitor2010

    • Author(s)
      徐岩(YAN XU)
    • Journal Title

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

      Volume: Vol.132 Pages: 631-637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Chiral Wedge Molecule Inhibits Telomerase Activity2010

    • Author(s)
      徐岩(YAN XU)
    • Journal Title

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

      Volume: Vol, 132 Pages: 3778-3782

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A U-Tetrad Stabilizes Human Telomeric RNA G-Quadruplex Structure2010

    • Author(s)
      徐岩(YAN XU)
    • Journal Title

      JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

      Volume: Vol, 132 Pages: 7231-7233

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomeric Repeat-Containing RNA Structure in Living Cells2010

    • Author(s)
      徐岩(YAN XU)
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: Vol, 107 Pages: 14579-14584

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒトテロメア RNA 四重鎖の構造と安定性2013

    • Author(s)
      楊 潔、石塚 匠、徐 岩
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Year and Date
      2013-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] クリック化学により染色体 DNA のマルチカラーイメージング2013

    • Author(s)
      劉泓汕、徐 岩
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 19F を含むテロメアRNA 四重鎖の構造と安定性2013

    • Author(s)
      鮑宏亮、徐 岩
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Year and Date
      2013-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] クリック化学により染色体DNA のマルチカラーイメージング2013

    • Author(s)
      劉泓汕
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトテロメアRNA 四重鎖の構造と安定性2013

    • Author(s)
      楊 潔
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 19Fを含むテロメアRNA四重鎖の構造と安定性2013

    • Author(s)
      鮑宏亮
    • Organizer
      日本化学会第93回春季年会
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県草津市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Structure and Biological Function of Telomere RNA2012

    • Author(s)
      徐 岩
    • Organizer
      第39回国際核酸化学シンポジウム
    • Place of Presentation
      名古屋大学豊田講堂(愛知県)
    • Year and Date
      2012-11-15
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ヒトテロメア DNA と RNA によるハイブリッド四重鎖の形成およびその生化学機能2012

    • Author(s)
      徐 岩
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      北海道大学高等教育推進機構
    • Year and Date
      2012-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 可動式 DNA origami 構造体の pH センサーへの応用2012

    • Author(s)
      徐 岩
    • Organizer
      日本化学会第92 春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 可動式DNA origami構造体のpHセンサーへの応用2012

    • Author(s)
      徐岩
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子間 RNA4重鎖構造による遺伝子発現の調節2012

    • Author(s)
      徐 岩
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子間RNA4重鎖構造による遺伝子発現の調節2012

    • Author(s)
      徐岩
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 長鎖 DNA 中の四重鎖構造を検出する方法の開発2012

    • Author(s)
      徐 岩
    • Organizer
      日本化学会第92 春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 長鎖DNA中の四重鎖構造を検出する方法の開発2012

    • Author(s)
      徐岩
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトテロメアDNAとRNAによるハイブリッド四重鎖の形成およびその生化学機能2012

    • Author(s)
      徐 岩
    • Organizer
      第6回バイオ関連化学シンポジウム
    • Place of Presentation
      北海道大学高等教育推進機構
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトテロメア RNA の構造と生化学機能およびテロメア RNA を標的とする小分子の探索2011

    • Author(s)
      徐 岩
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトテロメアRNAの構造と生化学機能およびテロメアRNAを標的とする小分子の探索2011

    • Author(s)
      徐岩
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] ARCUT による単一染色体のテロメア長測定2011

    • Author(s)
      石塚 匠、伊藤 健一郎、徐 岩、小宮山 眞
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学横浜キャンパス(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトテロメア RNAの構造と生化学機能について2011

    • Author(s)
      徐 岩、 小宮山 眞
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学横浜キャンパス (神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ARCUTによる単一染色体のテロメア長測定2011

    • Author(s)
      石塚匠
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学横浜キャンパス(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトテロメアRNAの構造と生化学機能について2011

    • Author(s)
      徐岩
    • Organizer
      日本化学会第91回春季年会
    • Place of Presentation
      神奈川大学横浜キャンパス(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] To Reveal Telomere's Mysterious by Chemical Approaches2011

    • Author(s)
      徐岩
    • Organizer
      Third International Symposium for Young Organic Chemists (3rd ISYOC)
    • Place of Presentation
      物質・材料研究機構 並木地区(茨城県)
    • Year and Date
      2011-03-03
    • Related Report
      2012 Final Research Report
  • [Presentation] To Reveal Telomere's Mysterious by Chemical Approaches2011

    • Author(s)
      徐岩
    • Organizer
      Third International Symposium for Young Organic Chemists(3rd ISYOC)
    • Place of Presentation
      物質・材料研究機構並木地区(茨城県)
    • Year and Date
      2011-03-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elucidation of structure and function of human telomere DNA/RNA and development of novel human telomere-targeted approaches2010

    • Author(s)
      徐 岩
    • Organizer
      2010 環太平洋国際化学会議
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Translational regulation by intermolecular RNA G-quadruplex2010

    • Author(s)
      K. Ito 、 YAN XU 、 M. Komiyama
    • Organizer
      2010 環太平洋国際化学会議
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] G-rich sequence-specific cleaving by PNA/DNA hybrid G-quadruplex formation2010

    • Author(s)
      T. Ishizuka、 M. Komiyama、 YAN XU
    • Organizer
      2010 環太平洋国際化学会議
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Elucidation of structure and function of human telomere DNA/RNA and development of novel human telomere-targeted approaches2010

    • Author(s)
      徐岩
    • Organizer
      2010環太平洋国際化学会議
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Translational regulation by intermolecular RNA G-quadruplex2010

    • Author(s)
      伊藤健一郎
    • Organizer
      2010環太平洋国際化学会議
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] G-rich sequence-specific cleaving by PNA/DNA hybrid G-quadruplex formation2010

    • Author(s)
      石塚匠
    • Organizer
      2010環太平洋国際化学会議
    • Place of Presentation
      ハワイコンベンションセンター
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 化学的アプローチによるヒトテロメア RNA 構造と機能の解析2010

    • Author(s)
      徐 岩、神長 邦行、鈴木 裕太、伊藤 健一郎、石塚 匠、木村 貴、小宮山 眞
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」(茨城県)
    • Year and Date
      2010-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 化学的アプローチによるヒトテロメアRNA構造と機能の解析2010

    • Author(s)
      徐岩
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」(茨城県)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分子間 G-quadruplex 構造によるタンパク質発現制御2010

    • Author(s)
      伊藤 健一郎、徐 岩、小宮山 眞
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」(茨城県)
    • Year and Date
      2010-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトテロメア四重鎖 RNA に結合する小分子の探索2010

    • Author(s)
      菊池 宏海 、 倉林 香織 、 Zeng Huaqiang、徐 岩、小宮山 眞
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」(茨城県)
    • Year and Date
      2010-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 分子間G-quadruplex構造によるタンパク質発現制御2010

    • Author(s)
      伊藤健一郎
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」(茨城県)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトテロメア四重鎖RNAに結合する小分子の探索2010

    • Author(s)
      徐岩
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場「エポカルつくば」(茨城県)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトテロメア RNAの構造と生化学機能2010

    • Author(s)
      徐 岩、小宮山 眞
    • Organizer
      第12回日本RNA 学会年会
    • Place of Presentation
      第12回日本RNA 学会年会
    • Year and Date
      2010-07-29
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトテロメアRNAの構造と生化学機能2010

    • Author(s)
      徐岩
    • Organizer
      第12回日本RNA学会年会
    • Place of Presentation
      学術総合センター(東京都)
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.miyazaki-med.ac.jp/MMCCHEM/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 宮崎大学医学部機能制御学講座物質科学分野研究室

    • URL

      http://www.miyazaki-med.ac.jp/MMCCHEM/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.miyazaki-med.ac.jp/MMCCHEM/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.miyazaki-med.ac.jp/MMCCHEM/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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