Creation of Functional Artificial Peptide Nanocapsules based onInternal Skeleton of Viral Capsids
| Project/Area Number |
22350075
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tottori University (2012)
Kyushu University (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Keywords | ペプチド / 自己集合 / ウイルスキャプシド / ナノカプセル / β-Annulusペプチド / タンパク質 |
|---|
| Research Abstract |
Recently, application of plant viruses to nanotechnology have attracted much attention due to their fascinating nanostructures with discrete nano-space. However, it remains difficult to rationally design artificial viral capsid. In this project, we found that a synthesized viral β-annulus peptide (24 residues) showed spontaneous self-assembly into hollow nanocapsules (synthetic viral capsid) with the size of 30-50 nm in water. Moreover, we have succeeded in synthesizing magnetite and encapsulating M13 phage DNA into the artificial capsids.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article]2012
Author(s)
K. Matsuura
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Journal Title
Polymer J
Volume: 44
Issue: 6
Pages: 469-474
DOI
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
K. Matsuura, K. Watanabe, K. Sakurai, T. Matsuzaki, and N. Kimizuka
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Journal Title
Angew. Chem. Int. Ed
Volume: 49
Issue: 50
Pages: 9662-9665
DOI
Related Report
Peer Reviewed
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[Remarks] 研究成果が以下のメディアに掲載された 科研費NEWSレター 2013年, Vol.1, 山陰中央新報 2013/3/26, 産経新聞夕刊 2013/3/25, 日本経済新聞夕刊 2013/3/25, 日本海新聞 2013/2/6, Yahooニュース 2013/1/25, マイナビニュース 2013/1/25, 産経新聞 2010/11/14, 西日本新聞夕刊 2010/11/13, Yahooニュース 2010/11/13
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