To develop neural chips using hPSC-derived neurons for facilitating in-vitro investigations of neural networks by nanofibers
| Project/Area Number |
22350104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Kyoto University |
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Principal Investigator |
CHEN Yong 京都大学, 物質-細胞統合システム拠点, 教授 (70512458)
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| Co-Investigator(Kenkyū-buntansha) |
LIU Li 京都大学, 物質-細胞統合システム拠点, 特定助教 (50380093)
亀井 謙一郎 京都大学, 物質-細胞統合システム拠点, 特定助教 (00588262)
野村 慎一郎 京都大学, 物質-細胞統合システム拠点, 特定研究員 (50372446)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 高分子機能材料 / ナノファイバマトリクス / 幹細胞工学 / 神経ネットワーク / ナノファイバーマトリクス / 神経細胞ネットワーク / 分化制御 |
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| Research Abstract |
We construct well-designed neural networks by using either embryonic or induced pluripotent stem cells. Both topographic and biochemical cell growth cues are patterned to guide the growth and connation of derived axons and dendrites. In addition, aligned nanofibers-based topographic and microfluidic circuits as well as integrated microelectrode arrays are used for more active control and monitoring cellular network activities. If successful, the derived neuron chips can be useful as model system for advanced study of drug screening.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Integrated and diffusion-based micro-injectors for open access cell assays2011
Author(s)
X.Li, L.Liu, L.Wang, K.Kamei, Q.Yuan, F.Zhang, J.Shi, A.Kusumi, M.Xie, Z.Zhao, Y.Chen
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Journal Title
Lab Chip
Volume: 11
Issue: 15
Pages: 2612-2617
DOI
Related Report
Peer Reviewed
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[Presentation] Microfluidic devices with disposable enzyme electrode for electrochemical monitoring of glucose concentrations2011
Author(s)
Fan Zhang, Xin Li, Jian Shi, Li Wang, Jing-Hua Tian, Xiong-Tu Zhou,Lian-Mei Jiang, Li Liu, Zhen-Jie Zhao, Pin-Gang He, Yong Chen
Organizer
The 3rd Chinese-French symposium on microfluidics
Place of Presentation
Dalian(China)
Year and Date
2011-10-30
Related Report
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[Presentation] Microfluidic devices with disposable enzyme electrode for electrochemical monitoring of glucose concentrations2011
Author(s)
Fan Zhang, Xin Li, Jian Shi, Li Wang, Jing-Hua Tian, Xiong-Tu Zhou, Lian-Mei Jiang, Li Liu, Zhen-Jie Zhao, Pin-Gang He, Yong Chen
Organizer
The 3rd Chinese-French symposium on microfluidics
Place of Presentation
Dalian(中国)
Year and Date
2011-10-30
Related Report
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