Preparation of thermo-responsive nano-carrier which can solubilize fullerene complex as a photosensitizer in water
| Project/Area Number |
22350106
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Polymer/Textile materials
|
|---|
| Research Institution | University of Hyogo |
|---|
Principal Investigator |
YUSA Shin-ichi 兵庫県立大学, 工学研究科, 准教授 (00301432)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWASE Takeshi 兵庫県立大学, 工学研究科, 教授 (10201443)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAGO Shigeru 京都大学, 化学研究所, 教授 (30222368)
KOMADA Fusao 姫路独協大学, 薬学部, 教授 (50306247)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
|
|---|
| Keywords | 精密ラジカル重合 / 高分子構造・物性 / ナノチューブ・フラーレン / ナノ材料 / 光物性 / 光線力学的療法 / 温度応答性 / 自己集合体 / 高分子合成 |
|---|
| Research Abstract |
Water-soluble diblock copolymer, poly(N-isopropylacrylamide)-block-poly(N-vinyl-2-pyrroridone) (PNIPAMm-b-PNVPn), was found to associate with fullerene (C_60), and thus C_60 can be solubilized in water. The C_60/PNIPAMm-b-PNVPn micelle formed an aggregate comprising a C_60/PNVP hydrophobic core and a thermoresponsive PNIPAM shell. The hydrodynamic radius of the C_60-bound polymer micelle increased with increasing temperature, which was ascribed to the hydrophobic association between dehydrated PNIPAM shells above lower critical solution temperature. The generation of singlet oxygen by photosensitization by the C_60-bound polymer micelle was confirmed from photooxidation of 9,10-anthracenedipropionic acid. Furthermore, DNA was found to be cleaved by visible light irradiation in the presence of the C_60-bound polymer micelle. Therefore, there may be a hope for a pharmaceutical application of the C_60-bound polymer micelle to cancer photodynamic therapy (PDT).
|
Report
(4 results)
Research Products
(288 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Novel LaBO_3 hollow nanospheres of size 34 ± 2 nm templated by polymeric micelles2012
Author(s)
M. Sasidharan, N. Gunawardhana, N. Gunawardhana, H. N. Luitel, T. Yokoi, M. Inoue, S. Yusa, T. Watari, M. Yoshio, T. Tatsumi, K. Nakashima
-
Journal Title
Journal of Colloid and Interface Science
Volume: 370
Pages: 51-57
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Solubilization of C60 by micellization with a thermoresponsive block copolymer in water: Characterization, singlet oxygen generation, and DNA photocleavage2011
Author(s)
S. Yusa, S. Awa, M. Ito, T. Kawase, T. Takada, K. Nakashima, D. Liu, S. Yamago, Y. Morishima
-
Journal Title
Journal of Polymer Science Part A: Polymer Chemistry
Volume: 49
Issue: 13
Pages: 2761-2770
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] pH-responsive Flocculation and Dispersion Behavior of Janus Particles in Water2011
Author(s)
M. Ito, R. Enomoto, K. Osawa, Y. Daiko, T. Yazawa, S. Fujii, Y. Yokoyama, Y. Miyanari, Y. Nakamura, A. Nakao, Y. Iwasaki, S. Yusa
-
Journal Title
Polymer Journal
Volume: 66
Issue: 2
Pages: 181-188
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Automatic ELISA analytical system for a trace amount of environmental chemicals using a 3-dimensional microreactor with a novel antigen-bound microfilter2012
Author(s)
M. Takeo, I. Kawaji, A. Nakasuji, T. Tone, Y. Ukita, D. Kato, S. Negoro, S. Yusa, M. Katayama, Y. Utsumi
Organizer
The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of Presentation
Okinawa, Japan
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
