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Localized surface plasmon sensing for detection and diagnosis of influenza viruses

Research Project

Project/Area Number 22360022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied optics/Quantum optical engineering
Research InstitutionMuroran Institute of Technology

Principal Investigator

KANO Hiroshi  室蘭工業大学, 工学研究科, 准教授 (80322874)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Hideki  国立感染症研究所, 感染病理部, 部長 (30301790)
MORIGAKI Kenichi  神戸大学, 遺伝子実験センター, 准教授 (10358179)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords光計測 / 表面プラズモン / 屈折率計測 / ウイルス / 顕微光計測 / 屈折率測定 / インフルエンザウイルス / 計測工学 / ウィルス
Research Abstract

A method to determine subtype of influenza viruses by using surface plasmons localized in microscopic region on a flat metal surface was developed. In this method, refractive index variation arisen from interactions between viruses and their monoclonal antibodies was measured. Theoretical calculation revealed that measurement region had a size of ~180nm in radius, and could be occupied by ~7 viruses. The detection of influenza viruses with certain subtype was successfully demonstrated.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (68 results)

All 2013 2012 2011 2010 Other

All Journal Article (21 results) (of which Peer Reviewed: 19 results) Presentation (45 results) (of which Invited: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Detection of influenza virus with specific subtype by using localized surface plasmons excited n a flat metal surface2013

    • Author(s)
      Jun Ning, Kotaro Nagata, Akira Ainai, Hideki Hasegawa, and Hiroshi Kano
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution simultaneous microscopy of refractive index and fluorescent intensity distributions by using localized surface plasmons2013

    • Author(s)
      G. Terakado, J. Ning, K. Watanabe, and H. Kano
    • Journal Title

      Appl. Opt.

      Volume: 52 Issue: 14 Pages: 3324-3328

    • DOI

      10.1364/ao.52.003324

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface functionalization of a polymeric lipid bilayer for coupling a model biological membrane with molecules2013

    • Author(s)
      K. Morigaki, K. Mizutani, M. Saito, T. Okazaki, Y. Nakajima, Y. Tatsu, H. Imaishi
    • Journal Title

      cells, and microstructures, Langmuir

      Volume: 29 Issue: 8 Pages: 2722-2730

    • DOI

      10.1021/la304747e

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microarrays of phospholipid bilayers generated by inkjet printing2013

    • Author(s)
      M. Yamada, H. Imaishi, and K. Morigaki
    • Journal Title

      Langmuir

      Volume: 29 Issue: 21 Pages: 6404-6408

    • DOI

      10.1021/la400570h

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localized surface plasmon microscopy of submicron domain structures of mixed lipid bilayers2012

    • Author(s)
      K. Watanabe, R. Miyazaki, G. Terakado, T. Okazaki, K. Morigaki, and H. Kano
    • Journal Title

      Biomed. Opt. Express

      Volume: 3 Issue: 9 Pages: 2012-2020

    • DOI

      10.1364/boe.3.002012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scanning and non-scanning surface plasmon microscopy to observe cell adhesion sites2012

    • Author(s)
      K. Watanabe, K. Matsuura, F. Kawata, K. Nagata, J. Ning, and H. Kano
    • Journal Title

      Biomed. Opt. Express

      Volume: Vol.3, No.2 Issue: 2 Pages: 354-359

    • DOI

      10.1364/boe.3.000354

    • NAID

      120004897833

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012

    • Author(s)
      A. Ainai, S. Tamura, T. Suzuki, R. Ito, H. Asanuma, T. Tanimoto, Y. Gomi, S. Manabe, T. Ishikawa, Y. Okuno, T. Odagiri, M. Tashiro, T. Sata, T. Kurata, H. Hasegawa
    • Journal Title

      J. Med. Virol.

      Volume: 84(2) Issue: 2 Pages: 336-344

    • DOI

      10.1002/jmv.22273

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam2012

    • Author(s)
      N. Nakajima, N. Van Tin, Y. Sato, HN Thach, H. Katano, PH Diep, T. Kumasaka, NT Thuy, H. Hasegawa, LT San, S. Kawachi, NT Liem, K. Suzuki, T. Sata
    • Journal Title

      Mod. Pathol.

      Volume: 26 Issue: 3 Pages: 357

    • DOI

      10.1038/modpathol.2012.193

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal IgA responses in influenza virus infections ; thoughts for vaccine design.2012

    • Author(s)
      E. van Riet, A. Ainai, T. Suzuki, H. Hasegawa
    • Journal Title

      Vaccine

      Volume: 30 Issue: 40 Pages: 5893-5900

    • DOI

      10.1016/j.vaccine.2012.04.109

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012

    • Author(s)
      Ainai, A.
    • Journal Title

      J. Med. Virol.

      Volume: 84 Pages: 336-344

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam2012

    • Author(s)
      Nakajima, N.
    • Journal Title

      Mod. Pathol.

      Volume: 26 Pages: 357-369

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal IgA responses in influenza virus infections; thoughts for vaccine design.2012

    • Author(s)
      van Riet, E.
    • Journal Title

      Vaccine

      Volume: 30 Pages: 5893-5900

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scanning and non-scanning surface plasmon microscopy to observe cell adhesion sites2012

    • Author(s)
      Koyo Watanabe, Koji Matsuura, Fukukazu Kawata, Kotaro Nagata, Jun Ning, Hiroshi Kano
    • Journal Title

      Biomed.Opt.Express

      Volume: 3 Pages: 354-359

    • NAID

      120004897833

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012

    • Author(s)
      Ainai A, Tamura S, Suzuki T, Ito R, Asanuma H, Tanimoto T, Gomi Y, Manabe S, Ishikawa T, Okuno Y, Odagiri T, Tashiro M, Sata T, Kurata T, Hasegawa H
    • Journal Title

      J Med Virol

      Volume: 84(2) Pages: 336-344

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection2012

    • Author(s)
      Nakajima N, Sato Y, Katano H, Hasegawa H, Kumasaka T, Hata S, Tanaka S, Amano T, Kasai T, Chong JM, Iiduka T, Nakazato I, Hino Y, Hamamatsu A, Horiguchi H, Tanaka T, Hasegawa A, Kanaya Y, Oku R, Oya T, Sata T
    • Journal Title

      Mod Pathol

      Volume: 25(1) Pages: 1-13

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel function of the N-terminal domain of PA in assembly of influenza Avirus RNA polymerase2011

    • Author(s)
      Suzuki T, Ainai A, Nagata N, Sata T, Sawa H, Hasegawa H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414(4) Issue: 4 Pages: 719-726

    • DOI

      10.1016/j.bbrc.2011.09.142

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel function of the N-terminal domain of PA in assembly of influenza A virus RNA polymerase2011

    • Author(s)
      Suzuki T, Ainai A, Nagata N, Sata T, Sawa H, Hasegawa H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414(4) Pages: 719-726

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-protective immunity against influenza virus infections induced by intranasal vaccination together with a TLR3-mucosal adjuvant.2011

    • Author(s)
      Ainai A, Tashiro M, Hasegawa H.
    • Journal Title

      Hum Vaccin.

      Volume: Jan 1;7. [Epub ahead of print]

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Passive immune-prophylaxis against influenza virus infection by the expression of neutralizing anti-hemagglutinin monoclonal antibodies from pl asmids.2011

    • Author(s)
      Yamazaki T, Nagashima M, Ninomiya D, Arai Y, Teshima Y, Fu jimoto A, Ainai A, Hasegawa H, Chiba J.
    • Journal Title

      Jpn J Infect Dis.

      Volume: 64(1) Pages: 40-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus.2010

    • Author(s)
      Ichinohe T, Ainai A, Ami Y, Nagata N, Iwata N, Kawaguchi A, Suzaki Y, Odagiri T, Tashiro M, Takahashi H, Strayer DR, Carter WA, Chiba J, Tamura S, Sata T, Kurata T, Hasegawa H.
    • Journal Title

      J Med Virol.

      Volume: 82(10) Pages: 1754-1761

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Characterization of quasispecies of pandemic 2009 influenza A virus (A/H1N1/2009) by de novo sequencing using a next-generation DNA seque ncer.2010

    • Author(s)
      Kuroda M, Katano H, Nakajima N, Tobiume M, Ainai A, Sekizuka T, Hasegawa H, Tashiro M, Sasaki Y, Arakawa Y, Hata S, Watanabe M, Sata T.
    • Journal Title

      PLOS One.

      Volume: 23;5(4)

    • Related Report
      2010 Annual Research Report
  • [Presentation] Localization of Surface Plasmons on a Flat Metal Surface and Its Applications to Bio-sensing, Optics & Photonics Taiwan2012

    • Author(s)
      Hiroshi Kano
    • Organizer
      International Conference (OPTIC 2012)
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2012-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of protective immune responses after intranasal administration of an inactivated whole-virion influenza vaccine in human2012

    • Author(s)
      H. Hasegawa
    • Organizer
      第16回日本ワクチン学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Localization of Surface Plasmons on a Flat Metal Surface and Its Applications to Bio-sensing2012

    • Author(s)
      Hiroshi Kano
    • Organizer
      International Union of Materials Research Societies - International Conference on Electronic Materials 2012 (IUMRS-ICEM 2012)
    • Place of Presentation
      横浜市
    • Year and Date
      2012-09-25
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Localizes Surface Plasmon Sensing of Single Influenza Virus with Specific Subtype2012

    • Author(s)
      Jun Ning
    • Organizer
      第73回応用物理学会学術講演会 JSAP-OSA joint symposium
    • Place of Presentation
      松山市
    • Year and Date
      2012-09-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Stable and functional model biological membrane composed of polymeric and fluid lipid bilayers2012

    • Author(s)
      Kenichi Morigaki
    • Organizer
      Engineering Lipid Bilayers
    • Place of Presentation
      Leeds (UK)
    • Year and Date
      2012-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Subtype determination of influenza viruses by a localized surface plasmon sensor2012

    • Author(s)
      K. Nagata
    • Organizer
      XI Conference on Optical Chemical Sensors and Biosensors (EUOPT(R)ODE XI)
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2012-04-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Surface functionalization of polymeric lipid bilayers for coupling with molecules, cell, and 3D objects2012

    • Author(s)
      森垣憲一
    • Organizer
      243 Meeting of the American Chemical Society
    • Place of Presentation
      San Diego
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Absorption sensor using localized surface plasmons2012

    • Author(s)
      J.Ning, G.Terakado, H.Kano
    • Organizer
      vironmental Science and Disaster Mitigation Resear
    • Place of Presentation
      Muroran, Japan
    • Year and Date
      2012-03-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 局所励起表面プラズモンを利用したウイルスセンシング2012

    • Author(s)
      加野 裕
    • Organizer
      日本生物物理学会2011年度北海道支部例会
    • Place of Presentation
      旭川市
    • Year and Date
      2012-03-06
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Subtype determination of influenza viruses by a localized surface plasmon sensor2012

    • Author(s)
      K. Nagata
    • Organizer
      XI Conference on Optical Chemical Sensors and Biosensors (EUOPT(R)ODE XI)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] Localization of Surface Plasmons on a Flat Metal Surface and Its Applications to Bio-sensing2012

    • Author(s)
      Hiroshi Kano
    • Organizer
      Optics & Photonics Taiwan, International Conference (OPTIC 2012)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 次世代ワクチンとしての経鼻インフルエンザワクチン2012

    • Author(s)
      長谷川秀樹
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis of protective immune responses after intranasal administration of an inactivated whole-virion influenza vaccine in human.2012

    • Author(s)
      Hasegawa, H.
    • Organizer
      第16回日本ワクチン学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stable and functional model biological membrane composed of polymeric and fluid lipid bilayers2012

    • Author(s)
      Kenichi Morigaki
    • Organizer
      Engineering Lipid Bilayers
    • Place of Presentation
      Leeds, UK
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Micropatterned biomimetic membrane composed of polymeric and fluid lipid bilayers2011

    • Author(s)
      森垣憲一
    • Organizer
      15th International Conference on Thin Films
    • Place of Presentation
      京都テルサ
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ポリマー脂質二分子膜を基盤とした生体膜機能界面の創製2011

    • Author(s)
      森垣憲一
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山大学
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 局所励起表面プラズモン屈折率センサーによる インフルエンザウイルス検出: 測定値の安定性評価2011

    • Author(s)
      永田 航太郎
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形市
    • Year and Date
      2011-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 局所励起表面プラズモン屈折率センサーによるインフルエンザウイルス検出:測定値の安定性評価2011

    • Author(s)
      永田航太郎, 寧君, 加野裕
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形市
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 輪帯瞳照明型局所励起表面プラズモン顕微鏡による脂質二分子膜観察:近赤外フェムト秒パルスレーザーを光源に用いた屈折率イメージング2011

    • Author(s)
      寺門吾郎, 寧君, 加野裕
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形市
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] FDTD calculation of electric field distribution produced by localized surface plasmons under annular pupil illumination2011

    • Author(s)
      Shinichiro Yamazaki
    • Organizer
      International Conference on Nanophotonics 2011
    • Place of Presentation
      Shanghai (China)
    • Year and Date
      2011-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] FDTD calculation of electric field distribution produced by localized surface plasmons under annular pupil illumination2011

    • Author(s)
      Shinichiro Yamazaki, Hiroshi Kano
    • Organizer
      International Conference on Nanophotonics 2011
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2011-05-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fluorescence and refractive index imaging by a localized surface plasmon microscope with annular ppil illumination2011

    • Author(s)
      G. Terakado
    • Organizer
      Focus on Microscopy FOM2011
    • Place of Presentation
      Konstanz, (Germany)
    • Year and Date
      2011-04-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Fluorescence and refractive index imaging by a localized surface plasmon microscope with annular pupil illumination2011

    • Author(s)
      G.Terakado, J.Ning, H.Kano
    • Organizer
      Focus on Microscopy FOM2011
    • Place of Presentation
      Konstanz, Germany
    • Year and Date
      2011-04-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Scanning and non-scanning surface plasmon microscopy of refractive index distribution on a metal surface2011

    • Author(s)
      F.Kawata, R.Miyazaki, G.Terakado, K.Watanabe, H.
    • Organizer
      Focus on Microscopy FOM2011
    • Place of Presentation
      Konstanz, Germany
    • Year and Date
      2011-04-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] INTRANASAL ADMINISTRATION OF 2009/10 ANNUAL INFLUENZA VACCINE INDUCE THE CROSS-PROTECTION AGAINST 2009 PANDEMIC INFLUENZA VIRUS INFECTION2011

    • Author(s)
      Akira Ainai, Ryo Ito, Hideki Asanuma, Tadaki Suzuki, Takeshi Tanimoto, Takato Odagiri, Shin-Ichi Tamura, Tetsutaro Sata, Masato Tashiro, Hideki Hasegawa
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] INFLUENZA SPECIFIC IGA PRODUCING SERUM MEMORY B CELLS CORRELATE TO PROTECTIVE ANTIBODIES IN THE SERUM AS WELL AS LOCAL IGA RESPONSES2011

    • Author(s)
      Elly van Riet, Akira Ainai, Ryo Ito, Tadaki Suzuki, Shin-Ichi Tamura, Masato Tashiro, Hideki Hasegawa
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] ANALYSIS OF THE IMMUNE RESPONSES AFTER INTRANASAL BOOSTER INFLUENZA VACCINE WITH HETEROLOGOUS VIRUS PRIMING2011

    • Author(s)
      Ryo Ito, Akira Ainai, Hideki Asanuma, Tadaki Suzuki, Joe Chiba, Shin-Ichi Tamura, Masato Tashiro, Tetsutaro Sata, Hideki Hasegawa
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] INTRANASAL ADMINISTRATION OF AN INACTIVATED WHOLE-VIRION INFLUENZA VACCINE EFFECTIVELY INDUCES THE NEUTRALIZING ANTIBODIES BOTH IN THE SERUM AND THE NASAL WASH IN HUMAN2011

    • Author(s)
      Hideki Hasegawa, Akira Ainai, Elly van Riet, Tadaki Suzuki, Ryo Ito, Takeshi Tanimoto, Takato Odagiri, Masato Tashiro, Tetsutaro Sata, Takeshi Kurata, Shin-Ichi Tamura
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] COMPARISON OF INFLUENZA A/H1N1 PDM09 VACCINE PRODUCTIONS IN EGGS VERSUS CELL CULTURES AND THE PROTECTIVE IMMUNE RESPONSES INDUCE IN MICE2011

    • Author(s)
      Hideki Asanuma, Mina Nakauchi, Kayoko Sato, Eri Nobusawa, Akira Ainai, Norio Yamamoto, Nami Konomi, Hideki Hasegawa, Masato Tashiro
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] ROLE OF THE N-TERMINAL REGION OF THE PA SUBUNIT IN NUCLEAR IMPORT AND ASSEMBLY OF INFUENZA A VIRUS RNA POLYMERASE2011

    • Author(s)
      Tadaki Suzuki, Akira Ainai, Noriyo Nagata, Tetsutaro Sata, Hideki Hasegawa
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] PASSIVE IMMUNOTHERAPY AGAINST INFLUENZA VIRUS INFECTION USING THE EXPRESSION OF NEUTRALIZING ANTI-HEMAGGLUTININ MONOCLONAL ANTIBODIES FROM PLASMIDS BY HYDRODYNAMICS-BASED PROCEDURE2011

    • Author(s)
      Tatsuya Yamazaki, Yasutomo Teshima, Daisuke Ninomiya, Maria Nagashima, Yuka Arai, Akira Fujimoto, Akira Ainai, Hideki Hasegawa, Joe Chiba
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Annual Research Report
  • [Presentation] 感染防御に効くインフルエンザワクチンを目指して2011

    • Author(s)
      長谷川秀樹
    • Organizer
      第15回日本ワクチン学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2009/10季節性インフルエンザワクチンの経鼻投与によるA/H1N1pdm09ウイルスの感染防御2011

    • Author(s)
      相内章、浅沼秀樹、谷本武史、小田切孝人、田村愼一、田代眞人、長谷川秀樹
    • Organizer
      第15回日本ワクチン学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Bio-membrane imaging by scanning and non-scanning localized surface plasmon microscopy2011

    • Author(s)
      F.Kawata, N.Jung, G.Terakado, H.Kano
    • Organizer
      Joint Seminar on Environmental Science and Disaster Mitigation Research 2011
    • Place of Presentation
      室蘭工業大学(室蘭市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Simulation of localized surface plasmons excited by using annular pupil illumination2011

    • Author(s)
      Sinichiro Yamazaki, Hiroshi Kano
    • Organizer
      Joint Seminar on Environmental Science and Disaster Mitigation Research 2011
    • Place of Presentation
      室蘭工業大学(室蘭市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Model biological membranes composed of polymerized and fluid lipid bilavers2011

    • Author(s)
      森垣憲一
    • Organizer
      241st Meeting of the American Chemical Society
    • Place of Presentation
      アナハイム(米国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 屈折率/蛍光分布を同時計測する表面プラズモン顕微鏡の像特性改善:レーザー光のビーム成形効果2010

    • Author(s)
      寺門吾郎, 渡辺向陽, 加野裕
    • Organizer
      第71回応用物珪学会学術講演会
    • Place of Presentation
      長崎大学(長崎市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経鼻粘膜投与型インフルエンザワクチンによるブースター効果と高病原性H5N1ウイルスの感染防御の検討2010

    • Author(s)
      長谷川秀樹、相内章、網康至、永田典代、田村慎一、谷本武史、真鍋貞夫、石川豊数、宮崎隆、小田切孝人、田代眞人、倉田毅、佐多徹太郎
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2009/10季節性インフルエンザワクチンの経鼻投与によるA/H1N1pdmウイルスの感染阻害効果の検討2010

    • Author(s)
      相内章、伊藤良、浅沼秀樹、鈴木忠樹、谷本武史、小田切孝人、田村慎一、佐多徹太郎、田代眞人、長谷川秀樹
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザ中和抗体発現プラスミドを用いた遺伝子治療による感染と重症化の阻止2010

    • Author(s)
      山崎達也、二宮大輔、長島麻里亜、荒井由佳、手嶋保智、相内章、長谷川秀樹、藤本陽、千葉丈
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経鼻インフルエンザワクチにおける抗原性の異なる株による追加免疫時の免疫応答の解析2010

    • Author(s)
      伊藤良、相内章、浅沼秀樹、鈴木忠樹、千葉丈、田村慎一、田代眞人、佐多徹太郎、長谷川秀樹
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本の2009年H1N1新型インフルエンザウイルス感染症剖検例の病理2010

    • Author(s)
      中島典子、佐藤由子、片野晴隆、長谷川秀樹、佐多徹太郎
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新型インフルエンザウイルスA/(H1N1)pdmのフェレットにおける病原性の検討2010

    • Author(s)
      長谷川秀樹、永田典代、岩田奈緒子、辻隆裕、佐多徹太郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 本邦初の新型インフルエンザウイルス(A/H1N1pdm)肺炎の剖検例2010

    • Author(s)
      中島典子、羽田悟、飛梅実、片野晴隆、永田典代、長谷川秀樹、岩田奈緒子、辻隆裕、渡辺正秀、佐多徹太郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Formation of substrate supported planar phospholipid bilayers in the presence of detergents2010

    • Author(s)
      岡田佳祐、今石浩正、森垣憲一
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      東北大学(仙台市)
    • Related Report
      2010 Annual Research Report
  • [Book] インフルエンザウイルスと人類の戦い2011

    • Author(s)
      長谷川秀樹
    • Total Pages
      207
    • Publisher
      シーアンドアール研究所
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www3.muroran-it.ac.jp/kanolab/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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