Localized surface plasmon sensing for detection and diagnosis of influenza viruses
| Project/Area Number |
22360022
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied optics/Quantum optical engineering
|
|---|
| Research Institution | Muroran Institute of Technology |
|---|
Principal Investigator |
KANO Hiroshi 室蘭工業大学, 工学研究科, 准教授 (80322874)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Hideki 国立感染症研究所, 感染病理部, 部長 (30301790)
MORIGAKI Kenichi 神戸大学, 遺伝子実験センター, 准教授 (10358179)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
|---|
| Keywords | 光計測 / 表面プラズモン / 屈折率計測 / ウイルス / 顕微光計測 / 屈折率測定 / インフルエンザウイルス / 計測工学 / ウィルス |
|---|
| Research Abstract |
A method to determine subtype of influenza viruses by using surface plasmons localized in microscopic region on a flat metal surface was developed. In this method, refractive index variation arisen from interactions between viruses and their monoclonal antibodies was measured. Theoretical calculation revealed that measurement region had a size of ～180nm in radius, and could be occupied by ～7 viruses. The detection of influenza viruses with certain subtype was successfully demonstrated.
|
Report
(4 results)
Research Products
(68 results)
-
-
-
-
-
-
-
[Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012
Author(s)
A. Ainai, S. Tamura, T. Suzuki, R. Ito, H. Asanuma, T. Tanimoto, Y. Gomi, S. Manabe, T. Ishikawa, Y. Okuno, T. Odagiri, M. Tashiro, T. Sata, T. Kurata, H. Hasegawa
-
Journal Title
J. Med. Virol.
Volume: 84(2)
Issue: 2
Pages: 336-344
DOI
Related Report
Peer Reviewed
-
[Journal Article] Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam2012
Author(s)
N. Nakajima, N. Van Tin, Y. Sato, HN Thach, H. Katano, PH Diep, T. Kumasaka, NT Thuy, H. Hasegawa, LT San, S. Kawachi, NT Liem, K. Suzuki, T. Sata
-
Journal Title
Mod. Pathol.
Volume: 26
Issue: 3
Pages: 357-369
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012
Author(s)
Ainai A, Tamura S, Suzuki T, Ito R, Asanuma H, Tanimoto T, Gomi Y, Manabe S, Ishikawa T, Okuno Y, Odagiri T, Tashiro M, Sata T, Kurata T, Hasegawa H
-
Journal Title
J Med Virol
Volume: 84(2)
Pages: 336-344
Related Report
Peer Reviewed
-
[Journal Article] Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection2012
Author(s)
Nakajima N, Sato Y, Katano H, Hasegawa H, Kumasaka T, Hata S, Tanaka S, Amano T, Kasai T, Chong JM, Iiduka T, Nakazato I, Hino Y, Hamamatsu A, Horiguchi H, Tanaka T, Hasegawa A, Kanaya Y, Oku R, Oya T, Sata T
-
Journal Title
Mod Pathol
Volume: 25(1)
Pages: 1-13
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus.2010
Author(s)
Ichinohe T, Ainai A, Ami Y, Nagata N, Iwata N, Kawaguchi A, Suzaki Y, Odagiri T, Tashiro M, Takahashi H, Strayer DR, Carter WA, Chiba J, Tamura S, Sata T, Kurata T, Hasegawa H.
-
Journal Title
J Med Virol.
Volume: 82(10)
Pages: 1754-1761
Related Report
-
[Journal Article] Characterization of quasispecies of pandemic 2009 influenza A virus (A/H1N1/2009) by de novo sequencing using a next-generation DNA seque ncer.2010
Author(s)
Kuroda M, Katano H, Nakajima N, Tobiume M, Ainai A, Sekizuka T, Hasegawa H, Tashiro M, Sasaki Y, Arakawa Y, Hata S, Watanabe M, Sata T.
-
Journal Title
PLOS One.
Volume: 23;5(4)
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] INTRANASAL ADMINISTRATION OF AN INACTIVATED WHOLE-VIRION INFLUENZA VACCINE EFFECTIVELY INDUCES THE NEUTRALIZING ANTIBODIES BOTH IN THE SERUM AND THE NASAL WASH IN HUMAN2011
Author(s)
Hideki Hasegawa, Akira Ainai, Elly van Riet, Tadaki Suzuki, Ryo Ito, Takeshi Tanimoto, Takato Odagiri, Masato Tashiro, Tetsutaro Sata, Takeshi Kurata, Shin-Ichi Tamura
Organizer
XV International Congress of Virology
Place of Presentation
Sapporo
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
