Supporting system for regenerative medicine by utilizing three-dimensional micro dynamic stimulations and active manipulations on the iPS cells
| Project/Area Number |
22360093
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dynamics/Control
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FENG Zhonggang 山形大学, 理工学研究科, 准教授 (10332545)
GOTO Kaoru 山形大学, 医学部, 教授 (30234975)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 動的刺激 / ３次元刺激 / iPS細胞 / アクティブ力学操作 / 分化誘導 / 細胞増殖 / 振動ステージ / 振動アクチュエータ / 3次元アクチュエータ / 3次元振動ステージ / ３次元動的力学刺激 / 分化誘導促進 / 神経細胞 / 選択的力学刺激 / 3次元動的力学刺激 / マウスiPS細胞 / アクティブ力学作 |
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| Research Abstract |
We have developed completely new small sized piezoelectric three-dimensional vibration stage and a micro vibration actuator, which enable us to enforce various micro dynamic stimulations upon the cultured living iPS cells colony as well as upon a single cell. The system, not like a conventional approach but based on the principle of mechanics, has an ability to support development of the regenerative medicine. The results suggest that utilization of appropriate dynamic stimulation may be a promising approach not only to accelerate iPS cells proliferation but also to improve differentiation efficiency of iPS cells into neurons as well as neuronal networking.
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Report
(5 results)
Research Products
(55 results)
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[Presentation] 動的力学刺激を用いたiPS細胞の培養コントロール2011
Author(s)
阿部 淳司, 今野 健一, 市田 徹, 工藤佳明, 小沢田 正, 馮 忠剛
Organizer
Dynamics and Design Conference 2011, CD-ROM 論文集204
Place of Presentation
高知工科大学
Year and Date
2011-09-05
Related Report
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[Presentation] iPS細胞の分化過程における力学特性の評価2010
Author(s)
会田 和広, 今野 健一, 阿部 淳司, 中村 健, 小沢田 正
Organizer
Dynamics and Design Conference 2011
Place of Presentation
同志社大学京田辺キャンパス
Year and Date
2010-09-15
Related Report
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[Presentation] 超小型3次元振動ステージの開発と細胞培養への応用2010
Author(s)
市田 徹 , 今野 健一 , 金山 寧 , 佐藤 亮太 , 小沢田 正, 馮 忠剛, 八月朔日 泰和 , 後藤 薫
Organizer
Dynamics and Design Conference 2011
Place of Presentation
同志社大学京田辺キャンパス
Year and Date
2010-09-15
Related Report
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