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Development of Accistance System for High Accuracy Breast Cancer Radio Frequency Ablation

Research Project

Project/Area Number 22360108
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionWaseda University

Principal Investigator

YOSHIMURA Masataka  早稲田大学, 理工学術院, 教授 (60026325)

Co-Investigator(Kenkyū-buntansha) FUJIE Masakatsu  早稲田大学, 理工学術院, 教授 (20339716)
MIYASHITA Tomoyuki  早稲田大学, 理工学術院, 教授 (20329080)
KOBAYASHI Yo  早稲田大学, 理工学術院, 准教授 (50424817)
WATANABE Hiroki  早稲田大学, 理工学術院, 助手 (00609266)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords乳がん / ラジオ波焼灼療法 / 治療支援システム / 生体医工学 / シミュレーション / モデルベース制御 / 熱物性 / 温度分布シミュレーション
Research Abstract

Recently the radio frequency ablation (RFA) treatment is focused on as minimally invasive treatment for breast cancer. In order to improve treatment effect of RFA, we developed the support system of RFA treatment for breast cancer ablation high accurately. Our system mainly consists of high accuracy temperature distribution simulator and optimal process for puncture. As the results of some in vivo experiments, the temperature distribution simulator enable to be high repeatability that the temperature difference between experimental results and analysis results is within 4.0 deg C. And, in obtaining the process of optimal puncture for breast cancer, we developed the optimal puncture condition. This condition was derived from in vitro experiments by using simulant cancer which was implanted in hog breast.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (47 results)

All 2013 2012 2011 2010

All Presentation (45 results) Patent(Industrial Property Rights) (2 results)

  • [Presentation] Validation of Accuracy of Liver Model with Temperature-Dependent ThermalConductivity by Comparing the Simulation and in vitro RF Ablation Experiment2012

    • Author(s)
      Hiroki Watanabe, Nozomu Yamazaki, YosukeIsobe, XiaoWei Lu, Yo Kobayashi, Tomoyuki Miyashita, Takeshi Ohdaira, Makoto Hashizume, Masakatsu G. Fujie
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 5712-5717
    • Related Report
      2012 Final Research Report
  • [Presentation] Modeling the dependence of electrical conductivity on internal lung pressure for lung RFA2012

    • Author(s)
      N. Yamazaki, Y. Isobe, H. Watanabe, T. Hoshi, Y. Kobayashi, T. Miyashita, and M. G. Fujie
    • Organizer
      Computer Assisted Radiology and Surgery 26th International Congress and Exhibition
    • Place of Presentation
      vol. 7, no. 1, S198-S199
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of a temperature distribution simulator for lung RFA based on air dependence of thermal and electrical properties2012

    • Author(s)
      Nozomu Yamazaki, Hiroki Watanabe, XiaoWei Lu, Yosuke Isobe, Yo Kobayashi, Tomoyuki Miyashita, and Masakatsu G. Fujie
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 5699-5702
    • Related Report
      2012 Final Research Report
  • [Presentation] A study on estimation of the deformation behavior in the collapse process of lung2012

    • Author(s)
      Yusuke Katsuyama, Nozomu Yamazaki, Yo Kobayashi, Takeharu Hoshi, and Tomoyuki Miyashita
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 2817-2822
    • Related Report
      2012 Final Research Report
  • [Presentation] A Method for Deriving the Coagulation Boundary of Liver Tissue Using a Relational Model of Viscoelasticity and Temperature in Radio Frequency Ablation2012

    • Author(s)
      XiaoWei Lu, Mariko Tsukune, Hiroki Watanabe, Nozomu Yamazaki, Yosuke Isobe, Yo Kobayashi, Tomoyuki Miyashita, and Masakatsu G. Fujie
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 187-190
    • Related Report
      2012 Final Research Report
  • [Presentation] Method for Distinduishing Coagulation Boundary Temperature in Liver Tissue for RF Ablation2012

    • Author(s)
      XiaoWei Lu, Mariko Tsukune, Nozomu Yamazaki, Hiroki Watanabe, Yo Kobayashi, Tomoyuki Miyashita, Takashi Kakimoto, Hiromasa, Yamashita, Toshio Chiba, Masakatsu Fujie
    • Organizer
      The 8 th Asian Conference on Computer Aided Surgery
    • Place of Presentation
      p. 11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝臓癌ラジオ波焼灼療法用温度分布シミュレータの開発とIn vitro 下における精度評価2012

    • Author(s)
      渡辺広樹,山崎望,磯部洋佑,呂筱薇, 小林洋,大平猛,橋爪誠,藤江正克
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2012
    • Place of Presentation
      2A2-S08
    • Related Report
      2012 Final Research Report
  • [Presentation] FAにおいて非対称形状の焼灼領域形成を可能にする電極針の機構の検討2012

    • Author(s)
      磯部洋佑,山崎望,渡辺広樹,小林洋, 宮下朋之,大平猛,橋爪誠,藤江正克
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2012
    • Place of Presentation
      2A2-S09
    • Related Report
      2012 Final Research Report
  • [Presentation] A Method for Distinguishing Coagulation Boundary for Liver RF Ablation2012

    • Author(s)
      呂筱薇,築根まり子,山崎望,渡辺広樹,小林洋,宮下朋之,藤江正克
    • Organizer
      第51回生体医工学会大会
    • Place of Presentation
      3-01-2
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝がんラジオ波焼灼療法における組織凝固指標の検討2012

    • Author(s)
      呂筱薇,築根まり子,磯部洋佑,山崎望,渡辺広樹,小林洋,柿本隆志,千葉敏雄,宮下朋之,藤江正克
    • Organizer
      第21回日本コンピュータ外科学会大会
    • Place of Presentation
      12(XXI)-112
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱伝導率と電気伝導率の空気量依存性を反映した肺のRFA用温度分布シミュレーションの構築2012

    • Author(s)
      山崎望,渡辺広樹,磯部洋佑,呂筱薇,小林洋,宮下朋之,藤江正克
    • Organizer
      第21回日本コンピュータ外科学会大会
    • Place of Presentation
      12(VIII)-40
    • Related Report
      2012 Final Research Report
  • [Presentation] Validation of Accuracy of Liver Model with Temperature-Dependent Thermal Conductivity by Comparing the Simulation and in vitro RF Ablation Experiment2012

    • Author(s)
      Hiroki Watanabe, Nozomu Yamazaki, Yosuke Isobe, XiaoWei Lu, Yo Kobayashi, Tomoyuki Miyashita, Takeshi Ohdaira, Makoto Hashizume, Masakatsu G. Fujie
    • Organizer
      The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’12)
    • Place of Presentation
      Sandiego
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝臓癌ラジオ波焼灼療法用温度分布シミュレータの開発とIn vitro下における精度評価2012

    • Author(s)
      渡辺 広樹,山崎 望,磯部 洋佑,呂 筱薇,小林 洋,大平 猛,橋爪 誠,藤江 正克
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2012 (Robomec’12)
    • Place of Presentation
      浜松
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of a temperature distribution simulator for lung RFA based on air dependence of thermal conductivity and electrical properties2012

    • Author(s)
      Nozomu Yamazaki, Hiroki Watanabe, XiaoWei Lu, Yo Kobayashi, Tomoyuki Miyashita, Masakatsu G. Fujie
    • Organizer
      The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’12)
    • Place of Presentation
      Sandiego
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Method for Deriving the Coagulation Boundary of Liver Tissue Using a Relational Model of Viscoelasticity and Temperature in Radio Frequency Ablation2012

    • Author(s)
      XiaoWei Lu, Mariko Tsukune, Hiroki Watanabe, Nozomu Yamazaki, Yosuke Isobe, Yo Kobayashi, Tomoyuki Miyashita, Masakatsu G. Fujie
    • Organizer
      The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’12)
    • Place of Presentation
      Sandiego
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Method for Distinduishing Coagulation Boundary Temperature in Liver Tissue for RF Ablation2012

    • Author(s)
      XiaoWei Lu, Mariko Tsukune, Nozomu Yamazaki, Hiroki Watanabe, Yo Kobayashi, Tomoyuki Miyashita, Takashi Kakimoto, Hiromasa Yamashita, Toshio Chiba, Masakatsu Fujie
    • Organizer
      The 8 th Asian Conference on Computer Aided Surgery (ACCAS’12)
    • Place of Presentation
      北京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Modeling the dependence of electrical cinductivity on internal lung pressue for lung RFA2012

    • Author(s)
      Nozomu Yamazaki, Yosuke Isobe, Hiroki Watanabe, Takeharu Hoshi, Yo Kobayashi, Tomoyuki Miyashita, Masakatsu G. Fujie
    • Organizer
      Computer Assisted Radiology and Surgery 2012 (CARS’12)
    • Place of Presentation
      Pisa
    • Related Report
      2012 Annual Research Report
  • [Presentation] RFAにおいて非対称形状の焼灼領域形成を可能にする電極針の機構の検討2012

    • Author(s)
      磯部 洋佑,山崎 望,渡辺 広樹,小林 洋,宮下 朋之,大平 猛,橋爪 誠,藤江正克
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会2012 (Robomec’12)
    • Place of Presentation
      浜松
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Method for Distinguishing Coagulation Boundary for Liver RF Ablation2012

    • Author(s)
      呂 筱薇,築根 まり子,山崎 望,渡辺 広樹,小林 洋,宮下 朋之,藤江 正克
    • Organizer
      第51回生体医工学会大会 (JSMBE 51)
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] A study on estimation of the deformation behavior in the collapse process of lung2012

    • Author(s)
      Yusuke Katsuyama, Nozomu Yamazaki, Yo Kobayashi, Takeharu Hoshi, and Tomoyuki Miyashita
    • Organizer
      The 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’12)
    • Place of Presentation
      Sandiego
    • Related Report
      2012 Annual Research Report
  • [Presentation] 有限要素法を用いたRFA中の臓器内血流量推定手法の提案2011

    • Author(s)
      渡辺広樹, 山崎望, 小林洋, 宮下朋之, 大平猛, 橋爪誠, 藤江正克
    • Organizer
      第20回日本コンピュータ外科学会大会,pp.286-287,2011
    • Place of Presentation
      横浜(神奈川県)
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺臓内部空気を考慮した温度分布シミュレータによる肺臓RFAの焼灼範囲の検討2011

    • Author(s)
      山崎望, 渡辺広樹, 関雅俊, 小林洋, 宮下朋之, 藤江正克
    • Organizer
      第20回日本コンピュータ外科学会大会,pp.292-293,2011
    • Place of Presentation
      横浜(神奈川県)
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Estimation of Intraoperative Blood Flow during Liver RF Ablation Using a Finite Element Methos-based Biomechanical Simulation2011

    • Author(s)
      渡辺広樹, 山崎望, 小林洋, 宮下朋之, 大平猛, 橋爪誠, 藤江正克
    • Organizer
      The proceedings of the 33rd Annual International Conference of the IEEE EMBS, pp.7441-7445, 2011
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Modeling the Internal Pressure dependence of Thermal Conductivity of Lung and in vitro Measurement of Temperature during RFA2011

    • Author(s)
      川崎望, 渡辺広樹, 関雅俊, 星雄陽, 小林洋, 宮下朋之, 藤江正克
    • Organizer
      The proceedings of the 33rd Annual International Conference of the IEEE EMBS, pp.5753-5757, 2011
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thermal Conductivity and Temperature Distribution during Radio Frequency Ablation of Lung2011

    • Author(s)
      山崎望, 渡辺広樹, 関雅俊, 星雄陽, 小林洋, 宮下朋之, 藤江正克
    • Organizer
      Proceeding of Computer Assisted Radiology and Surgery, S120-S121, 2011
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thermal conductivity and temperature distribution during radio frequency ablation of lung2011

    • Author(s)
      N. Yamazaki, H. Watanabe, M. Seki, T. Hoshi, Y. Kobayashi, T. Miyashita, M. G. Fujie
    • Organizer
      Computer Assisted Radiology and Surgery 25th International Congress and Exhibition
    • Place of Presentation
      vol. 6, no. 1, S120-S121,
    • Related Report
      2012 Final Research Report
  • [Presentation] Modeling the Internal Pressure Dependence of Thermal Conductivity and in vitro Temperature Measurement for Lung RFA2011

    • Author(s)
      Nozomu Yamazaki, Hiroki Watanabe, Masatoshi Seki, Takeharu Hoshi, Yo kobayashi, Tomoyuki Miyashita, Masakatsu G. Fujie
    • Organizer
      33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 5753-5757
    • Related Report
      2012 Final Research Report
  • [Presentation] Estimation of Intraoperative Blood Flow during Liver RF Ablation Using a Finite Element Method-based Biomechanical Simulation2011

    • Author(s)
      Hiroki Watanabe, Nozomu Yamazaki, Yo Kobayashi, Tomoyuki Miyashita, Takeshi Ohdaira, Makoto Hashizume, Masakatsu G. Fujie
    • Organizer
      33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 7441-7445
    • Related Report
      2012 Final Research Report
  • [Presentation] 有限要素法を用いたRFA 中の臓器内血流量推定手法の提案2011

    • Author(s)
      渡辺広樹,山崎望,小林洋,宮下朋之,大平猛,橋爪誠,藤江正克
    • Organizer
      第20回日本コンピュータ外科学会大会
    • Place of Presentation
      vol. 13,no. 3,p. 286-287
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺臓内部空気を考慮した温度分布シミュレータによる肺臓RFA の焼灼範囲の検討2011

    • Author(s)
      山崎望,渡辺広樹,関雅俊,小林洋,宮下朋之,藤江正克
    • Organizer
      第20回日本コンピュータ外科学会大会
    • Place of Presentation
      vol. 13,no. 3,p. 292-293
    • Related Report
      2012 Final Research Report
  • [Presentation] 熱伝導率と導電率の空気依存性に基づく肺の熱伝導現象の定量化2011

    • Author(s)
      山崎望, 渡辺広樹, 小林洋, 宮下朋之, 藤江正克
    • Organizer
      ライフサポート学会
    • Place of Presentation
      p. 48
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝臓RFA用温度分布推定シミュレータの開発 ~血流が温度分布に及ぼす影響についての基礎的検討~2010

    • Author(s)
      渡辺広樹
    • Organizer
      第11回計測自動制御学会システムインテグレーション部門講演会
    • Place of Presentation
      宮城県,仙台市
    • Year and Date
      2010-12-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臓器物理モデルを規範とした画像誘導下RFA支援ロボットシステムの開発2010

    • Author(s)
      渡辺広樹
    • Organizer
      第5回OpenMRI研究会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Organ Biomechanical Simulators for Model based Control of Robotic RFAblation System2010

    • Author(s)
      Hiroki Watanabe
    • Organizer
      IEEE International Symposium on Micro-NanoMechatoronics and Human Science
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血流の存在を考慮した肝臓RFA用温度分布シミュレータの開発2010

    • Author(s)
      渡辺広樹
    • Organizer
      第19回日本コンピューター外科学会大会
    • Place of Presentation
      福岡県,福岡市
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺臓のラジオ波施工中における電極針近傍の温度測定2010

    • Author(s)
      山崎望
    • Organizer
      第19回日本コンピューター外科学会大
    • Place of Presentation
      福岡県,福岡市
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺の熱伝導率の内部圧力依存性の測定2010

    • Author(s)
      山崎望
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2010
    • Place of Presentation
      大阪府,豊中市
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temperature Dependence of Thermal Conductivity of Liver Based on Various Experiments and a Numerical Simulation for RF Ablation2010

    • Author(s)
      Hiroki Watanabe
    • Organizer
      International Conference of the IEEE Engineeringin Medicine and Biology Society
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Temperature Dependence of Thermal Conductivity of Liver Based on Various Experiments and a NumericalSimulation for RF Ablation2010

    • Author(s)
      Hiroki Watanabe, Nozomu Yamazaki, Yo Kobayashi, Tomoyuki Miyashita, Makoto Hashizume, Masakatsu G. Fujie
    • Organizer
      32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      p. 3222-3228
    • Related Report
      2012 Final Research Report
  • [Presentation] Organ Biomechanical Simulators for Model based Control of Robotic RF Ablation System2010

    • Author(s)
      Hiroki Watanabe, Yo Kobayashi, Masakatsu G. Fujie
    • Organizer
      the 2010 IEEE International Symposium on Micro-Nano Mechatoronics and Human Science
    • Place of Presentation
      p. 95-100
    • Related Report
      2012 Final Research Report
  • [Presentation] 臓器物理モデルを規範とした画像誘導下RFA 支援ロボットシステムの開発2010

    • Author(s)
      渡辺広樹
    • Organizer
      第5回Open MRI 研究会
    • Place of Presentation
      p. 12
    • Related Report
      2012 Final Research Report
  • [Presentation] 血流の存在を考慮した肝臓RFA 用温度分布シミュレータの開発2010

    • Author(s)
      渡辺広樹,山崎望,小林洋,大平猛,橋爪誠, 藤江正克
    • Organizer
      第19回日本コンピュータ外科学会大会
    • Place of Presentation
      vol.12, no. 3,p. 296-297
    • Related Report
      2012 Final Research Report
  • [Presentation] 肝臓RFA 用温度分布推定シミュレータの開発~血流が温度分布に及ぼす影響についての基礎的検討~2010

    • Author(s)
      渡辺広樹, 山崎望, 小林洋, 大平猛, 橋爪誠, 藤江正克
    • Organizer
      第11回計測自動制御学会システムインテグレーション部門講演会(11th SICE System Integration Division Annual Conference)
    • Place of Presentation
      1158-1160
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺の熱伝導率の内部圧力依存性の測定2010

    • Author(s)
      山崎望, 渡辺広樹,関雅俊,小林洋,宮下朋之,藤江正克
    • Organizer
      生活生命支援医療福祉工学系学会連合大会
    • Place of Presentation
      p. 459-460
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺臓のラジオ波施工中における電極針近傍の温度測定2010

    • Author(s)
      山崎望, 渡辺広樹, 関雅俊, 小林洋, 宮下朋之, 藤江正克
    • Organizer
      第19回日本コンピュータ科学会大会
    • Place of Presentation
      vol.12,no. 3, p. 302-303
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 穿刺対象臓器の血流量推定システム、温度分布推定システム、解析装置、及び解析装置用プログラム2013

    • Inventor(s)
      藤江正克, 小林洋, 渡辺広樹,山崎望,橋爪誠,大平猛
    • Industrial Property Rights Holder
      学校法人早稲田大学, 国立大学法人九州大学
    • Acquisition Date
      2013-03-04
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 穿刺対象臓器の血流量推定システム、温度分布推定システム、解析装置、及び解析装置用プログラム2011

    • Inventor(s)
      藤江正克, 小林洋, 渡辺広樹,山崎望,橋爪誠,大平猛
    • Industrial Property Rights Holder
      学校法人早稲田大学, 国立大学法人九州大学
    • Filing Date
      2011-08-26
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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