A STUDY ON ELECTRIC CHARGE/LEVEL CHARACTERIZATION DEVICES FOR BIOLOGICAL MATERIALS WITH METAL/MICRO-GAP/SEMICONDUCTOR ARRAYS

• Project/Area Number: 22360125
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Electronic materials/Electric materials
• Research Institution: Osaka University
• Principal Investigator: MORITA Mizuho 大阪大学, 大学院工学研究科, 教授 (50157905)
• Co-Investigator(Renkei-kenkyūsha): MITSUBAYASHI Kohji 東京医科歯科大学, 生体材料工学研究所, 教授 (40307236)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
• Keywords: シリコン / シリコン酸化膜 / 微小空隙 / 電荷分析 / センシングデバイス

Research Abstract

The electrical sensing of deoxyribonucleic acid hybridization by capacitance-voltage measurements of metal/micro-gap/insulator/semiconductor structure devices has been demonstrated. The hybridization of deoxyribonucleic acid has been characterized from the shift of the capacitance-voltage curve for the sensing device. It has been demonstrated that a metal/micro-gap/insulator/semiconductor structure device can distinguish between deoxyribonucleic acid hybridization and un-hybridization. The electrical sensing operation of pure water by capacitance-voltage measurements of a metal/micro-gap/insulator/semiconductor array has been demonstrated.

Research Products

• [Presentation] Efficient and Scalable Liquid Handling in Micro/Nano-fluidic System for biomedical applications (2013)
  • Author(s): Kentaro Kawai, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: PROGRAM AND ABSTRACT, Collaborative Conference on 3D & Materials Research
  • Place of Presentation: Jeju, South Korea
  • Year and Date: 2013-06-24
• [Presentation] NOMALLY-CLOSED VALVE INTEGRATION FOR PNEUMATIC ACTUATORS (2013)
  • Author(s): Kentaro Kawai, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: TRANSDUCERS 2013 & EUROSENSORS XXVII
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2013-06-17
• [Presentation] Efficient and Scalable Liquid Handling in Micro/Nano-fluidic System for biomedical applications (2013)
  • Author(s): Kentaro Kawai, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: PROGRAM AND ABSTRACT, Collaborative Conference on 3D & Materials Research
  • Place of Presentation: Ramada Plaza Jeju Hotel, Jeju, South Korea
• [Presentation] Nanogap electrochemical DNA sensor using flat band voltage shift (2012)
  • Author(s): Takuya Juro, Kentaro Kawai, Yuichi Doi, Takashi Furukawa, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: PROGRAM AND ABSTRACTS, 8th Handai Nanoscience and Nanotechnology International Symposium
  • Place of Presentation: Osaka
  • Year and Date: 2012-11-11
• [Presentation] Label-Free Detection of DNA Using Metal-Gap-Metal-Insulator-Semiconductor Devices (2012)
  • Author(s): Takashi Furukawa, Yasunori Nakamukai, Yuichi Doi, Kentaro Kawai, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Fifth International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2012-10-23
• [Presentation] Label-Free Detection of DNA Hybridization Using Metal-Gap-Oxide-Silicon Structures (2012)
  • Author(s): Yuichi Doi, Sonoko Nishiue, Takashi Furukawa, Kentaro Kawai, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Fifth International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2012-10-23
• [Presentation] Non-FET electrochemical DNA detection using metal-gap-oxide-silicon structures (2012)
  • Author(s): Kentaro Kawai, Yuichi Doi, Takashi Furukawa, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: PACIFIC RIM MEETING ON ELECTROCHEMICAL AND SOLID-STATE SCIENCE
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2012-10-09
• [Presentation] Metal-gap-oxide-silicon sensor for electrochemical DNA detection by flat band voltage shift (2012)
  • Author(s): Kentaro Kawai, Takuya Juro, Yuichi Doi, Takashi Furukawa, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: 38th International Conference on Micro and Nano Engineering
  • Place of Presentation: Toulouse, France
  • Year and Date: 2012-09-17
• [Presentation] Metal-gap-oxide-silicon sensor for electrochemical DNA detection by flat band voltage shift (2012)
  • Author(s): Kentaro Kawai, Takuya Juro, Yuichi Doi, Takashi Furukawa, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: Abstracts, 38th International Conference on Micro and Nano Engineering
  • Place of Presentation: Toulouse, France
• [Presentation] Non-FET electrochemical DNA detection using metal-gap-oxide-silicon structures (2012)
  • Author(s): Kentaro Kawai, Yuichi Doi, Takashi Furukawa, Junichi Uchikoshi, Kenta Arima, and Mizuho Morita
  • Organizer: Abstract, PACIFIC RIM MEETING ON ELECTROCHEMICAL AND SOLID-STATE SCIENCE
  • Place of Presentation: Honolulu, USA
• [Presentation] Continuous Generation of Femtoliter Droplets Using Multistage Dividing Microfluidic Channel (2011)
  • Author(s): Kentaro Kawai, Junichi Uchikoshi, Kenta Arima, Shuichi Shoji and Mizuho Morita
  • Organizer: Extended Abstracts of Fourth International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2011-11-01
• [Presentation] Electrical Sensing of DNA Solutions by Lateral Silicon-Oxide-Gap-Oxide-Silicon Structure on Silicon-on-Insulator Substrate (2011)
  • Author(s): Taiji Kamiya, Takashi Furukawa, Yuichi Doi, Ryuta Yamada, Kentarou Kawai, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Fourth International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2011-11-01
• [Presentation] Electrical Characteristics of Metal-Gap-Oxide-Silicon Structures (2011)
  • Author(s): Yuichi Doi, Takashi Furukawa, Kentaro Kawai, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Fourth International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2011-11-01
• [Presentation] Electrical Characteristics of Metal-Gap-Silicon and Metal-Gap-Oxide-Silicon Structures (2011)
  • Author(s): Takashi Furukawa, Yuuichi Doi, Kentaro Kawai, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Fourth International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2011-11-01
• [Presentation] Photonic and Biosensing Devices Using Silicon Technologies (2010)
  • Author(s): Mizuho Morita, Junichi Uchikoshi and Kenta Arima
  • Organizer: Extended Abstracts of Third International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2010-11-26
• [Presentation] Electrical Characterization of DNA Solutions Using Metal-Gap-Insulator-Semiconductor Devices (2010)
  • Author(s): Takaaki Hirokane, Yuichi Doi, Takashi Furukawa, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Third International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2010-11-24
• [Presentation] Sensing of DNA Solution by Silicon-Oxide-Gap-Oxide-Silicon Structure (2010)
  • Author(s): Taiji Kamiya, Ryuta Yamada, Junichi Uchikoshi, Kenta Arima and Mizuho Morita
  • Organizer: Extended Abstracts of Third International Symposium on Atomically Controlled Fabrication Technology
  • Place of Presentation: Osaka
  • Year and Date: 2010-11-24
• [Remarks]
  • URL: http://www-pm.prec.eng.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www-pm.prec.eng.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www-pm.prec.eng.osaka-u.ac.jp/