| Project/Area Number |
22360299
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Material processing/treatments
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Kyosuke 東北大学, 大学院・工学研究科, 助教 (40507901)
KAWAMURA Hiroshi 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (00110651)
KASUGA Toshihiro 名古屋工業大学, 大学院・工学研究科, 教授 (30233729)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TAIRA Masayuki 岩手医科大学, 歯学部, 准教授 (60179398)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 表面 / 界面制御 / チタン / 非晶質リン酸カルシム / シリコン / 生体吸収性 / 表面改質 / 骨適合性 / ドライプロセス / 動物実験 / 非晶質リン酸カルシウム / リン酸八カルシウム / ウェットプロセス |
|---|
| Research Abstract |
In vivo and in vitro evaluations of an amorphous calcium phosphate film formed on commercially pure titanium were conducted. Titanium implants coated with amorphous calcium phosphate were given to the femur and tibia of white rabbits. The implant stability quotient (ISQ) and bone implant contact for titanium implants were statistically improved by the coating of amorphous calcium phosphate. The coating film was absorbed during an implantation period of two-weeks; the release of Ca and P-related ions due to this absorption was suggested to play an important role in the improvement of bone compatibility. Further, the addition of Nb to the amorphous calcium phosphate film was an effective technique to control its resorbability in biological environments.
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