| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
High-reliability solubility of Rs-(±)-ibuprofen, caffeine and theophylline in supercritical carbon dioxide, which is very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, was measured. The versatility of nanoparticle production apparatus and nanoparticle design technique ofdrugs using the RESS technique proposed by the authors was very high because the apparatus and particle design technique could be applied to several dnlgs such as theophylline, caffeine, vanillin, and (-) -bomeol. Moreover, controlling the expansion nozzle temperatures was ofimportance to control the polymorph of the drugs using the RESS technique.
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