Development of basic research for practical application of particle design technique of drugs using the rapid expansion of supercritical solutions (RESS) technique
| Project/Area Number |
22360320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 超臨界二酸化炭素 / 超臨界溶体急速膨張法 / 薬物 / ナノ粒子 / 粒子設計 / 溶解度 / 微粒子 / 結晶形態・多形制御 / 固体共溶媒効果 / 気液固三相平衡 / フィージビリティスタディ |
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| Research Abstract |
High-reliability solubility of Rs-(±)-ibuprofen, caffeine and theophylline in supercritical carbon dioxide, which is very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, was measured. The versatility of nanoparticle production apparatus and nanoparticle design technique ofdrugs using the RESS technique proposed by the authors was very high because the apparatus and particle design technique could be applied to several dnlgs such as theophylline, caffeine, vanillin, and (-) -bomeol. Moreover, controlling the expansion nozzle temperatures was ofimportance to control the polymorph of the drugs using the RESS technique.
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Report
(4 results)
Research Products
(122 results)
