Construction of functional peptide ligands toward peptide biochips
| Project/Area Number |
22360341
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
MIHARA Hisakazu 東京工業大学, 生命理工学研究科, 教授 (30183966)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Hiroshi 東京工業大学, 大学院生命理工学研究科, 助教 (70398105)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | バイオチップ / ペプチド / 捕捉剤 |
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| Research Abstract |
To develop peptide biochips with high-throughput functions, a variety of peptide ligands were constructed by means of chemical and phage-display methods. It is successfully demonstrated that functional peptides were synthesized by a phage-display method using a beta-loop peptide library, peptide-displaying phage-chips were constructed, a variety of sugar-conjugated peptides (with gold-nanoparticles) were prepared, and peptides functioning to cells were also constructed.
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Report
(4 results)
Research Products
(17 results)
