| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
Heparin-collagen conjugate as a growth factor-immobilizable material was developed. This conjugate was able to form gel condition spontaneously. This conjugate was effective as not only culture substratum but also transplantable material for hepatocytes. Furthermore, the decellularization method of liver was optimized. Organ-scale scaffold having fine vascular-tree network was developed. Vascular endothelial cell and hepatocyte were inoculated into this scaffold and cultured. Base structure of liver substitute was successfully developed. This enabled blood extracorporeal circulation. Therefore, the effectiveness of this base structure as a transplantable liver substitute was expected. Based on above-mentioned results, newly developed technology in this study will be a potential method for the creation of practical liver tissue engineering.
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