Cell-free display technology for optimization of antibody drugs
| Project/Area Number |
22360351
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biofunction/Bioprocess
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
DOI Nobuhide 慶應義塾大学, 理工学部, 准教授 (50327673)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YANAGAWA Hiroshi 慶應義塾大学, 理工学部, 訪問教授 (40327672)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUSHIMA Koji 東京大学, 大学院・医学系研究科, 教授 (50222427)
MISUMI Shogo 熊本大学, 医学薬学研究部, 准教授 (40264311)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
|---|
| Keywords | ウイルス / バイオテクノロジー / 免疫学 / 蛋白質 / 進化 |
|---|
| Research Abstract |
In this study, we performed in vitro evolution of a humanized single-chain antibody against a cyclic peptide that mimics the extracellular loop-2 of CCR5,which is a key target of inhibitory drugs for the entry of HIV (Human Immunodeficiency Virus), by usi
|
Report
(4 results)
Research Products
(26 results)
-
-
[Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2012
Author(s)
Doi,N.,Yamakawa,N.,Matsumoto,H.,Yamamoto,Y.,Nagano,T.,Matsumura,N.,Horisawa,K.,Yanagawa,H
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2011
Author(s)
Doi,N.,Yamakawa,N.,Matsumoto,H.,Yamamoto,Y.,Nagano,T.,Matsumura,N.,Horisawa,K.,Yanagawa,H.
-
Journal Title
PLoS ONE
Volume: 7
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] mRNA display selection of a high-affinity, Bcl-XL-specific binding peptide2010
Author(s)
Matsumura, N., Tsuji, T., Sumida, T., Kokubo, M., Onimaru, M., Doi, N., Takashima, H., Miyamoto-Sato, E., Yanagawa, H
-
Journal Title
FASEB J
Volume: 24
Pages: 2201-2210
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
