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Molecular mechanism of homologous chromosome pairing in meiotic prophase

Research Project

Project/Area Number 22370004
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Genetics/Genome dynamics
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

DLNG Daqiao  独立行政法人情報通信研究機構, 未来1CT研究所バイオ1CT研究室, 主任研究員 (50359080)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords染色体 / 遺伝学 / 減数分裂 / RNA / 相同組換え / 対合 / 非コードRNA / 非コードRNA
Research Abstract

Pairing of homologous chromosome is an essential step in meiosis to ensure effective homologous recombination and reductional segregation in meiotic division. However, no mechanisms for chromosome specific recognition have ever been found. Here we found a meiotic-specific non-coding RNA, meiRNA-L, which forms an RNA dot on chromosome, plays an important role in recognition and pairing of homologous chromosome in early stage of meiosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (19 results) (of which Invited: 2 results) Remarks (4 results)

  • [Journal Article] Chromosomally-retained RNA mediates homologous pairing2012

    • Author(s)
      Ding DQ, Haraguchi T, Hiraoka Y
    • Journal Title

      Nucleus

      Volume: Volume 3 (6) Pages: 516-519

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis2012

    • Author(s)
      Ding DQ , Okamasa K, Yamane M, Tsutsumi C, Haraguchi T, Yamamoto M, and Hiraoka Y
    • Journal Title

      Science

      Volume: 336 (6082) Pages: 732-736

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes2012

    • Author(s)
      Akira Yamashita, Yuichi Shichino, Hirotsugu Tanaka, Edwige Hiriart, Leila Touat-Todeschini, Aurelia Vavasseur, Da-Qiao Ding, Yasushi Hiraoka, Andre Verdel, Masayuki Yamamoto
    • Journal Title

      Open Biology

      Volume: 2 Issue: 3 Pages: 120014-120014

    • DOI

      10.1098/rsob.120014

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis2012

    • Author(s)
      Ding D-Q, Okamasa K, Yamane M, Tsutsumi C, Haraguchi T, Yamamoto M, and Hiraoka Y
    • Journal Title

      Science

      Volume: 336 Issue: 6082 Pages: 732-736

    • DOI

      10.1126/science.1219518

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomally-retained RNA mediates homologous pairing2012

    • Author(s)
      丁 大橋
    • Journal Title

      Nucleus

      Volume: 3 Issue: 6 Pages: 516-519

    • DOI

      10.4161/nucl.22732

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非コードRNAが相同染色体の相互認識を担う2012

    • Author(s)
      丁 大橋
    • Journal Title

      実験医学

      Volume: 30 Pages: 2617-2619

    • Related Report
      2012 Annual Research Report
  • [Journal Article] A rush hour towards sexual reproduction: The chromosome dynamics during meiosis2011

    • Author(s)
      Ding DQ
    • Journal Title

      Chinese Science Bulletin

      Volume: Vol. 56, No. 33 Pages: 3500-3503

    • Related Report
      2012 Final Research Report
  • [Journal Article] A rush hour towards sexual reproduction : The chromosome dynamics during meiosis2011

    • Author(s)
      丁大橋
    • Journal Title

      Chinese Science Bulletin

      Volume: 56(33) Issue: 33 Pages: 3500-3503

    • DOI

      10.1007/s11434-011-4800-9

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Virtual breakdown of the nuclear envelope in fission yeast meiosis2010

    • Author(s)
      Asakawa H, Kojidani T, Mori C, Osakada H, Sato M, Ding DQ, Hiraoka Y and Haraguchi T
    • Journal Title

      Curr. Biol.

      Volume: 20 Pages: 1919-1925

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virtual breakdown of the nuclear envelope in fission yeast meiosis.2010

    • Author(s)
      淺川東彦
    • Journal Title

      Current Biology

      Volume: 20 Pages: 1919-1925

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis

    • Author(s)
      丁大橋
    • Journal Title

      Science

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分裂酵母減数分裂期染色体構造の相同染色体対合における役割2012

    • Author(s)
      丁大橋
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡県
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Non-coding RNA mediates robust pairing of homologous chromosomes in meiosis2012

    • Author(s)
      丁 大橋
    • Organizer
      The American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Philadelphia Pennsylvania Convention Center・アメリカ
    • Year and Date
      2012-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 相同染色体認識における非コードDNAの役割2012

    • Author(s)
      丁大橋
    • Organizer
      新学術研究領域「ゲノムを支える非コード領域の機能」第三回領域会議
    • Place of Presentation
      御殿場高原時之栖、静岡県
    • Year and Date
      2012-06-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 分裂酵母減数分裂期の染色体対合に寄与するノンコーディングRNA2011

    • Author(s)
      丁大橋
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 分裂酵母減数分裂期の染色体対合に寄与するノンコーディングRNA2011

    • Author(s)
      丁大橋
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis2011

    • Author(s)
      平岡泰
    • Organizer
      The EMBO Conference on Meiosis (2^<nd>)
    • Place of Presentation
      Capaccio/Paestum, Italy(招待講演)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pairing and recognition of homologous chromosomes in meiosis2011

    • Author(s)
      平岡泰
    • Organizer
      Pombe2011 The 6th International Fission Yeast Meeting
    • Place of Presentation
      ボストン、アメリカMartin Conference Center(招待講演)
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis2011

    • Author(s)
      丁大橋
    • Organizer
      Pombe2011 The 6th International Fission Yeast Meeting
    • Place of Presentation
      Martin Conference Center、ボストン・アメリカ
    • Year and Date
      2011-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis2011

    • Author(s)
      丁大橋
    • Organizer
      Pombe2011 The 6th International Fission Yeast Meeting
    • Place of Presentation
      ボストン、アメリカMartin Conference Center
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Anon-coding RNA-dependent meiotic homologous chromosome pairing site in fission yeast2011

    • Author(s)
      丁 大橋
    • Organizer
      International Symposium on the Physicochemical Field for Genetic Activities
    • Place of Presentation
      The Westin淡路、兵庫県
    • Year and Date
      2011-01-24
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Virtual breakdown of the nuclear envelope in fission yeast meiosis.2011

    • Author(s)
      淺川東彦
    • Organizer
      International Symposium on the Physicochemical Field for Genetic Activities
    • Place of Presentation
      The Westin淡路、兵庫県
    • Year and Date
      2011-01-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Non coding RNA mediates robust pairing of homologous chromosomes inmeiosis.2010

    • Author(s)
      丁大橋
    • Organizer
      The American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Philadelphia Pennsylvania Convention Center U.S.A
    • Year and Date
      2010-12-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分裂酵母相同染色体の認識と対合に寄与するnon-coding RNA2010

    • Author(s)
      丁大橋
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸市
    • Year and Date
      2010-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 分裂酵母相同染色体の認識と対合に寄与するnon-coding RNA2010

    • Author(s)
      丁大橋
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸市(招待講演)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 減数分裂前期の相同染色体対合に寄与する非コードRNA2010

    • Author(s)
      丁大橋
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場、大阪府
    • Year and Date
      2010-05-21
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 相同染色体認識における非コードDNAの役割

    • Author(s)
      丁 大橋
    • Organizer
      新学術研究領域「ゲノムを支える非コード領域の機能」第三回領域会議
    • Place of Presentation
      御殿場高原時之栖、静岡県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 減数分裂特異的な非コードRNAが相同染色体を認識する

    • Author(s)
      平岡泰
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡県
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 分裂酵母減数分裂期染色体構造の相同染色体対合における役割

    • Author(s)
      丁大橋
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡県
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 核内RNA ボディーが相同染色体の認識に果たす役割

    • Author(s)
      平岡泰
    • Organizer
      第30 回 染色体ワークショップ・第 11 回 核ダイナミクス研究会
    • Place of Presentation
      淡路夢舞台国際会議場、兵庫県
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks] 生物情報グループ

    • URL

      http://www2.nict.go.jp/advanced_ict/bio/w131103/CellMagic/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www-karc.nict.go.jp/w131103/CellMagic/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www-karc.nict.go.jp/w131103/CellMagic/index.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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