| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
Asexual planarians of Dugesia ryukyuensis can switch to the sexual mode if they are fed with sexual planarians of the different as well as the same species; this means that they contain sex-inducing substances that are not species-specific. In this study, we performed the functional analysis of Dr-DAO (D-amino acid oxidase in D. ryukyuensis) in order to examine the localization in a body of D-Trp, which we have already identified as an ovarian inducing substance. This revealed that the four D-amino acids other than D-Trp can induce the ovaries. We also isolated Dr-5HTR1 as a candidate of receptor for D-Trp. Otherwise, we obtained a more purified fraction including D-Trp with a strong sex-inducing activity. D-Trp may give rise to a strong sex-inducing activity with the substances containing in the fraction.
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