Mechanisms underlying switching from asexual to sexual reproduction by D-Tryptophan in the planarian Dugesia ryukryuensis
| Project/Area Number |
22370026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Hirosaki University (2012)
Keio University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Midori 慶應義塾大学, 理工学部, 准教授 (00211574)
TANAKA Hiroyuki 滋賀医科大学, 医学部, 助教 (10293820)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | D体アミノ酸 / トリプトファン / 配偶子形成 / 生殖様式 / プラナリア |
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| Research Abstract |
Asexual planarians of Dugesia ryukyuensis can switch to the sexual mode if they are fed with sexual planarians of the different as well as the same species; this means that they contain sex-inducing substances that are not species-specific. In this study, we performed the functional analysis of Dr-DAO (D-amino acid oxidase in D. ryukyuensis) in order to examine the localization in a body of D-Trp, which we have already identified as an ovarian inducing substance. This revealed that the four D-amino acids other than D-Trp can induce the ovaries. We also isolated Dr-5HTR1 as a candidate of receptor for D-Trp. Otherwise, we obtained a more purified fraction including D-Trp with a strong sex-inducing activity. D-Trp may give rise to a strong sex-inducing activity with the substances containing in the fraction.
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Report
(4 results)
Research Products
(48 results)
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[Presentation] D-amino acid oxidase represses the sexual induction in the planarian Dugesia ryukyuensis2011
Author(s)
Maezawa, T., Tanaka, H., Nakagawa, H., Horiike, K., Kobayashi, K
Organizer
Planarian Regeneration Research Meeting in Kyoto
Place of Presentation
Kyoto, Japan
Year and Date
2011-11-22
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