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Identification of transporters involved in excretion of toxic sulfate and borate by seawater fish

Research Project

Project/Area Number 22370029
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionTokyo Institute of Technology

Principal Investigator

HIROSE Shigehisa  東京工業大学, 大学院・生命理工学研究科, 教授 (10134199)

Co-Investigator(Renkei-kenkyūsha) KATO Akira  東京工業大学, 大学院・生命理工学研究科, 助教 (40311336)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords動物生理化学 / ホウ酸 / 輸送体 / 海水適応 / Slc4a11 / アクアポリン / AQP / 魚類 / 近位尿細管 / メフグ / 硫酸イオン輸送体 / 腎臓 / ホウ酸イオン輸送体 / Slc26a6A / 局在部位
Research Abstract

Sulfate and borate are abundant anion in seawater (SW), and excretion of excess sulfate and borate from ingested SW is essential for marine fish to survive because they are toxic. Marine teleosts excrete sulfate and borate via the urine produced in the kidney. The transporters that secrete and concentrate sulfate and borate in the urine have not previously been identified. Here, we have identified and characterized candidates for the long-sought transporters by using euryhaline pufferfish mefugu.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Remarks (2 results)

  • [Journal Article] Expression of a novel isoform of Na^+/H^+ exchanger 3 in the kidney and intestine of banded houndshark, Triakisscyllium2013

    • Author(s)
      Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 304 Issue: 10 Pages: R865-R876

    • DOI

      10.1152/ajpregu.00417.2012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a novel isoform of Na+/H+ exchanger 3 (NHE3) in the kidney and intestine of banded houndshark Triakis scyllium2013

    • Author(s)
      Li Shanshan et al.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and properties of a novel variant of NBC4 (Na+/HCO3- co-transporter 4) that is predominantly expressed in the choroid plexus2013

    • Author(s)
      Fukuda H. et al.
    • Journal Title

      Biochem J

      Volume: 450 Issue: 1 Pages: 179-187

    • DOI

      10.1042/bj20121515

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Euryhaline pufferfish NBCe1 differs from nonmarine species NBCe1 physiology2012

    • Author(s)
      Chang MH, Plata C, Kurita Y, Kato A, Hirose S, Romero MF
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 302 Issue: 8 Pages: C1083-C1095

    • DOI

      10.1152/ajpcell.00233.2011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 魚類のイオンホメオスタシス維持機構2012

    • Author(s)
      広瀬茂久
    • Journal Title

      生化学

      Volume: 84 Pages: 821-828

    • NAID

      10031122388

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and apical membrane localization of an electrogenic Na^+/Ca^2^+ exchanger NCX2a likely to be involved in renal Ca^2^+ excretion by seawater fish2011

    • Author(s)
      Islam Z, Kato A, Romero MF, Hirose S
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 301 Issue: 5 Pages: R1427-R1439

    • DOI

      10.1152/ajpregu.00165.2011

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of Na^+-Cl^- cotransporter and Na+-K^+^-Cl^- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes2011

    • Author(s)
      Kato A, Muro T, Kimura Y, Li S, Islam Z, Ogoshi M, Doi H, Hirose S.
    • Journal Title

      Am J Physiol Regul IntegrComp Physiol

      Volume: 300 Issue: 2 Pages: R284-R297

    • DOI

      10.1152/ajpregu.00725.2009

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammoniaexposure2010

    • Author(s)
      Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
    • Journal Title

      J Exp Biol.

      Volume: 213 Issue: 18 Pages: 3150-3160

    • DOI

      10.1242/jeb.044719

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rhesus glycoprotein p2(Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney2010

    • Author(s)
      Nakada, T., Westhoff, C. M., Yamaguchi, Y., Hyodo, S., Li, X., Muro, T., Kato, A., Nakamura, N., Hirose, S.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 4 Pages: 2653-2664

    • DOI

      10.1074/jbc.m109.052068

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.2010

    • Author(s)
      Nakada, T., et al.
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 2653-2664

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of zebrafish FXYD11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis2010

    • Author(s)
      Saito, K., et al.
    • Journal Title

      Front. Physiol.

      Volume: 1(129) Pages: 1-14

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure2010

    • Author(s)
      Nawata, M., et al
    • Journal Title

      J.Exp.Biol.

      Volume: 213 Pages: 3150-3160

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brief migration of the grass puffer Takifugu niphobles to fresh water from salt water.2010

    • Author(s)
      Kato, A., et al.
    • Journal Title

      Ichthyol.Res.

      Volume: 57 Pages: 298-304

    • NAID

      10026514613

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of renal transporters involved in sulfate excretion inmarine teleost fish2009

    • Author(s)
      Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.
    • Journal Title

      Am J Physiol RegulIntegr Comp Physiol

      Volume: 297 Issue: 6 Pages: R1647-R1659

    • DOI

      10.1152/ajpregu.00228.2009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.hirose.bio.titech.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.hirose.bio.titech.ac.jp/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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