| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Research Abstract |
The innate immune system is the self-defense system of higher eukaryotic organisms. The response of the system begins upon a recognition of pathogens such as bacteria and viruses by Toll-like Receptor(TLR) on the plasma membrane of immune cells. Once TLRs are activated by this recognition step, various cytosolic adaptor proteins such as MyD88 interact with the cytosolic region of TLRs to make a signal transduction complex. In this study, the interaction between adaptor proteins were studied. In addition, the receptor activation mechanism by Interlekin-18, the intracellular signal transduction pathway of which is shared with TLRs, were investigated.
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