Structural study of the Toll-like receptors signaling
Project/Area Number |
22370038
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Structural biochemistry
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Research Institution | Kyoto University |
Principal Investigator |
TOCHIO Hidehito 京都大学, 大学院・工学研究科, 准教授 (70336593)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
Keywords | MyD88 / IRAK / 自然免疫 / Toll 様受容体 / NF-κB / IL-18 / 炎症 / 構造生物学 / X線結晶構造解析 / NMR / インフラマソーム / Toll様受容体 |
Research Abstract |
The innate immune system is the self-defense system of higher eukaryotic organisms. The response of the system begins upon a recognition of pathogens such as bacteria and viruses by Toll-like Receptor(TLR) on the plasma membrane of immune cells. Once TLRs are activated by this recognition step, various cytosolic adaptor proteins such as MyD88 interact with the cytosolic region of TLRs to make a signal transduction complex. In this study, the interaction between adaptor proteins were studied. In addition, the receptor activation mechanism by Interlekin-18, the intracellular signal transduction pathway of which is shared with TLRs, were investigated.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Real-time background-free selective imaging of fluorescent nanodiamond in vivn2012
Author(s)
Ryuji Igarashi, Yohsake Yoshinari, Riroaki Yokoia, Takuma Sugi, Fuminori Sugihara, Kazuhiro Ikeda, Hiroshi Sumiya, Shigenori Tsuji, Ikme Mori, Hidehito Tochio, Yoshie Rarada, Masahiro Shirakawa.
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Journal Title
Nano Letters
Volume: 12
Issue: 11
Pages: 5726-5732
DOI
Related Report
Peer Reviewed
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[Journal Article] Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF12012
Author(s)
K.Arita, S.Isogai, T.Oda, M.Unoki, K.Sugita, N.Sekiyama, K.Kuwata, R.Hamamoto, H.Tochio, M.Sato, M.Ariyoshi, and M.Shirakawa
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109
Issue: 32
Pages: 12950-12955
DOI
Related Report
Peer Reviewed
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[Journal Article] TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.2012
Author(s)
Ohnishi H, Tochio H, Kato Z, Kawamoto N, Kimura T, Kubota K, Yamamoto T, Funasaka T, Nakano H, Wong RW, Shirakawa M, Kondo N.
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Journal Title
PLoS One.
Volume: 7
Issue: 6
Pages: e38423-e38423
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling.2012
Author(s)
Nada M, Ohnishi H, Tochio H, Kato Z, Kimura T, Kubota K, Yamamoto T, Kamatari YO, Tsutsumi N, Shirakawa M, Kondo N.
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Journal Title
Mol Immunol.
Volume: 52
Issue: 3-4
Pages: 108-116
DOI
Related Report
Peer Reviewed
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[Journal Article] Crystal structure of the UBA domain of p62 and its interaction with ubiquitin2011
Author(s)
Isogai, S., Morimoto, D., Arita, K., Unzai, S., Tenno, T., Hasegawa, J., Sou, Y.S., Komatsu, M., Tanaka, K., Shirakawa, M., Tochio, H.
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Journal Title
J Biol Chem.
Volume: 286
Issue: 36
Pages: 31864-318674
DOI
Related Report
Peer Reviewed
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