Molecular mechanism of the growth inhibition of normal cells withgalectin-3
| Project/Area Number |
22370048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagaoka University of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Takeshi 長岡技術科学大学, 工学部, 准教授 (30291131)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 細胞増殖制御 / 細胞密度依存 / ガレクチン-3 / VCAM-1 / 細胞内カルシウム / エクソソーム / ERM タンパク質 / 細胞内情報 / ERMタンパク質 / 細胞表面糖鎖 / 細胞増殖抑制 / 血管内皮細胞接着分子-1 / 繊維芽細胞 / 創傷治癒 |
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| Research Abstract |
To understand the mechanism of the wound healing, contact-dependent inhibition of growth has been studied using fibroblast cells. In the present study by employing the above system, we showed several steps are involved in this process; firstly calcium ion whose intracellular concentration increases upon increased cell density stimulates secretion of galectin-3 through exosomes, secondly galectin-3 secreted binds VCAM-1 through its N-glycans at the cell surface, thirdly the galectin-3/VCAM-1 complex inactivates the MAPK pathway, and finally the proliferation of the cells is ceased.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] A comprehensiveanalysis of proteins and metabolites inroots and hypocotyls of soybean underflooding stress using proteomics andmetabolomics techniques2011
Author(s)
Komatsu, S., Yamamoto, A., Nakamura, T., Nouri, M.-Z., Nanjo, Y., Nishizawa, K.,and Furukawa, K.
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Journal Title
J. ProteomeRes
Volume: 10
Issue: 9
Pages: 3993-4004
DOI
Related Report
Peer Reviewed
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[Journal Article] β4-Galactosyltransferases 2, 3, 4,5, 6 and 7. Handbook of Glycosyltrans-ferases and Related Genes (2nd Version)(N.Taniguchi et al., eds
Author(s)
Furukawa, K., Clausen, H., and Sato, T.
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Journal Title
Springer,Tokyo
Volume: (in press)
Related Report
Peer Reviewed
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