| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Research Abstract |
To understand the mechanism of the wound healing, contact-dependent inhibition of growth has been studied using fibroblast cells. In the present study by employing the above system, we showed several steps are involved in this process; firstly calcium ion whose intracellular concentration increases upon increased cell density stimulates secretion of galectin-3 through exosomes, secondly galectin-3 secreted binds VCAM-1 through its N-glycans at the cell surface, thirdly the galectin-3/VCAM-1 complex inactivates the MAPK pathway, and finally the proliferation of the cells is ceased.
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