| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
The modes of action of Draper, an engulfment receptor responsible for the phagocytosis of apoptotic cells in Drosophila, were investigated. Draper underwent tyrosine phosphorylation at the motif NPxY when phagocytes recognized apoptotic cells. This tyrosine residue was required for Draper to transmit signals for the induction of phagocytosis. The endoplasmic reticulum protein CaBP1 and the membrane phospholipid phosphatidylserine were found to serve as ligands for Draper. In addition, integrin αPS3-βν was identified as another engulfment receptor that functions independent of Draper.
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