Analysis of self-renewal mechanisms of embryonic stem cells
| Project/Area Number |
22370050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOIDE Hiroshi 金沢大学, 医学系, 准教授 (70260536)
AKAGI Tadayuki 金沢大学, 医学系, 助教 (70532183)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 細胞情報伝達機構 / 未分化性維持機構 / ES細胞 / 自己複製 / Dax1 / Oct3/4 / Esrrb / LRH1 / 幹細胞 / エピジェネティクス / 細胞周期 / クロマチンリモデリング / エピジェネティックス / クロマチン・リモデリング |
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| Research Abstract |
Mouse embryonic stem (ES) cells have two major characteristics: self-renewal capacity and pluripotency. Here, we focused on Eed (epigenetic controlling factor), Baf53a (chromatin remodeler), LRH-1 (cell cycle regulator), and transcription factor network (relationship among Oct3/4, Dax1 and Esrrb; and Gli). From the investigations of these factors, we revealed molecular mechanisms of self-renewal capacity of ES cells.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen-dependent prostate cancer cells2012
Author(s)
Okamoto R, Delansorne R, Wakimoto N, Doan NB, Akagi T, Shen M, Ho QH, Said JW, Koeffler HP
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Journal Title
Int J Cancer
Volume: 130
Issue: 10
Pages: 2464-73
DOI
Related Report
Peer Reviewed
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[Journal Article] RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me32012
Author(s)
Tavares L, Dimitrova E, Oxley D, Webster J, Poot R, Demmers J, Bezstarosti K, Taylor S, Ura H, Koide H, Wutz A, Vidal M, Elderkin S, Brockdorff N
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Journal Title
Cell
Volume: 148
Issue: 4
Pages: 664-78
DOI
Related Report
Peer Reviewed
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[Journal Article] Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia2010
Author(s)
Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler HP
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Journal Title
Haematologica.
Volume: 95
Issue: 9
Pages: 1481-8
DOI
Related Report
Peer Reviewed
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