Molecular mechanism and physiological role of FLASH with pleiotropic activities
| Project/Area Number |
22370052
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
YONEHARA Shin 京都大学, 大学院・生命科学研究科, 教授 (00124503)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 細胞周期 / 転写 / 細胞分化 / ES細胞 / Ars2 / CoREST複合体 / LSD1 |
|---|
| Research Abstract |
FLASH has been shown to be required for replication-dependent histone transcription and S phase progression. We showed that FLASH is involved in transcriptional regulation through modulating histone methylation by directly interacting to histone lysine-specific demethylase 1 (LSD1) and corepressor of REST 1 (CoREST1) in the CoREST1 complex. We also showed that induced knockout of FLASH does not affect proliferation of diploid fibroblasts and ES cells, and FLASH was shown to be dispensable for ES cells to differentiate into mesoderm, endoderm, and trophoblast. FLASH might be required for cell-cycle progression specifically in transformed cells
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Dclk1 distinguishes between tumor and normal stem cells in the intestine2013
Author(s)
Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A, Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, and Chiba T.
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Journal Title
Nat Genet
Volume: 45
Pages: 98-103
NAID
Related Report
Peer Reviewed
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[Journal Article] SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation2011
Author(s)
Uza N, Nakase H, Yamamoto S, Yoshino T, Takeda Y, Ueno S, Inoue S, Mikami S, Matsuura M, Shimaoka T, Kume N, Minami M, Yonehara S, Ikeuchi H, and Chiba T
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Journal Title
Gut
Volume: 60
Pages: 1494-1505
NAID
Related Report
Peer Reviewed
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