| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2010: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
As a working principle of biomolecular motors, it is important to understand the regulation of chemical reactions by motor movements and conformational changes in enzymes. Here, we studied theoretically how a double-headed kinesin, one of the best characterized molecular motors, can regulate motions of two heads and addressed what is the structural basis for this cooperation. We found that the nucleotide-dependent tensions between the two heads are the fundamentals, and by that, unidirectional and chemically tight coupling between two heads are realized.
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