Simulation study of biomolecular motors: Structural analysis of regulation mechanisms of chemical reaction by motor movements
| Project/Area Number |
22370057
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKADA Shoji 京都大学, 大学院・理学研究科, 教授 (60304086)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2010: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | キネシン / ATP加水分解 / 分子動力学 / 粗視化モデル / APT加水分解 |
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| Research Abstract |
As a working principle of biomolecular motors, it is important to understand the regulation of chemical reactions by motor movements and conformational changes in enzymes. Here, we studied theoretically how a double-headed kinesin, one of the best characterized molecular motors, can regulate motions of two heads and addressed what is the structural basis for this cooperation. We found that the nucleotide-dependent tensions between the two heads are the fundamentals, and by that, unidirectional and chemically tight coupling between two heads are realized.
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Report
(4 results)
Research Products
(86 results)
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[Book] 生物物理2010
Author(s)
高田彰二
Total Pages
2
Publisher
日本生物物理学会、
Related Report
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