Ribosomal abnormalities and human diseases: Molecular pathogenesis of ribosomopathies
| Project/Area Number |
22370065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KENMOCHI Naoya 宮崎大学, フロンティア科学実験総合センター, 教授 (00133124)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Tsutomu 東京大学, 工学研究科, 教授 (20292782)
TAKAYANAGI Atsushi 慶應義塾大学, 医学部, 講師 (80245464)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 翻訳 / リボソーム / 造血異常 / 発がん / ゼブラフィッシュ / 核小体 / p53 / リボソーム病 / 疾患モデル |
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| Research Abstract |
The ribosome, as the protein synthesis machinery, is essential to all organisms. Recently, it became clear that ribosomal abnormalities cause pleiotropic effects that may manifest as specific disease conditions in humans called ribosomopathies. To investigate the molecular pathogenesis of ribosomopathies, we developed zebrafish models of the diseases and found important factors that may link to the disease pathogenesis. In addition, we also developed databases that serve as a basis for the study of ribosomopathies.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function2011
Author(s)
Ikeda M, Andoo A, Shimono M, Takamatsu N, Taki A, Muta K, Matsushita W, Uechi T, Matsuzaki T, Kenmochi N, Takata K, Sasaki S, Ito K, Ishibashi K.
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Journal Title
J Biol Chem
Volume: 286
Issue: 5
Pages: 3342-3350
DOI
Related Report
Peer Reviewed
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