| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
(1) Generation and phenotype analysis of whole body and neuron-specific Drp1-KO mice.Tissue-specific Drp1-KO mice including liver, oocyte. heart muscle, and pancreatic beta-cell have been generated and their phenotypes are now under investigation.
(2) Identification of Mff of mitochondrial outer membrane (MOM) as the major Drp1 receptor.
(3) Identification of a new KIF family protein KLP6 functioning as an axonal mitochondria transport motor.
(4) Identified a Rab-GAP protein TBC1D15 as the ligand of MOM hFis1 protein involved in mitochondrial morphology regulation.
(5) Demonstration that Drp1 depletion or inhibition of its function increases mitochondrial nucleoid size concomitant with the mitochondrial network extension and formation of tightly packed cristae structure as a response to prevent cells from apoptotic death.
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