Integrin dependent cellular growth and functions through the mammalianhippo pathway
| Project/Area Number |
22370072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | Mst1,Mst2,インテグリン / Outside-in シグナル / Rap1 / Mst1 / Mat2 / インテグリン / Mst2 / Outside-inシグナル |
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| Research Abstract |
Mst1/Mst2, Mammalian homolog of Hippo associates with Rap1 effector RAPL and regulates lymphocyte adhesion and migration through leukocyte integrin LFA-1. Furthermore, RAPL negatively regulate cell cycle through G1 cyclin inhibitor p27Kip1. In addition, tissue imaging analysis has revealed that Mst1 is required for efficient thymocyte trafficking and selection. Consequently, deficiencies of RAPL and Mst1 lead to lymphoproliferative and autoimmune-like disorders.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migrataon during immune responses2012
Author(s)
Yosuke Harada, Yoshihiko Tanaka, Masao Terasawa, Markus Pieczyk, Katsuyoshi Habiro, Tomoya Katakai, Kyoko Hanawa-Suetsugu, Mutsuko Kukimoto-Niino, Tomoko Nishizaki, Mikako Shirouzu, Xuefeng Duan, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Shigeyuki Yokoyama, Jens V.Stein, Tatsuo Kinashi, Yoshinori Fukui
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Journal Title
Blood
Volume: (In press)
Issue: 19
Pages: 4451-4461
DOI
Related Report
Peer Reviewed
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[Journal Article] RAPL deficiency causedlymphoproliferative disordersthrough the mislocalization of p27kip.2011
Author(s)
Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K.I, Kinashi, T.
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Journal Title
Immunity.
Volume: 34
Pages: 1-15
Related Report
Peer Reviewed
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[Journal Article] RAPL deficiency caused lymphoproliferative disorders through the mislocalization of p27^<kip>2011
Author(s)
Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K.I, Kinashi, T.
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Journal Title
Immunity
Volume: 34
Pages: 24-38
Related Report
Peer Reviewed
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[Presentation] Mst1 regulates thymocyte trafficking and antigen recognition within thymic tissues2011
Author(s)
Ueda Yoshihiro1, Katagiri Koko2, Tomiyama Takashi1, Yasuda Kaneki1, Habiro Katsuyoshi1, Katakai Tomoya1, Ikehara Susumu3, Kinashi Tatsuo1, (1Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University. 2Department of Bioscience, School of Science and Technology, Kwansei Gakuin University. 3Department of Stem Cell Disorders. Kansai Medical University.)
Organizer
2011 The Annual Meeting of the Japanese Society for Immunology
Place of Presentation
Makuhari Messe Chiba Japan
Related Report
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