| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Research Abstract |
The chromosomal bouquet arrangement, in which ends of chromosomes cluster near a centrosome, is widely observed at the meiotic prophase. Bouquet defective mutants of Schizosaccharomyces pombe show defects in pairing of homologous chromosomes, spindle formation, and segregation of chromosomes. In this research, it was demonstrated that such defects in meiotic spindle formation are caused by disengagement of centrosome from the nuclear envelope. That is, if the centrosome is normally located on the nuclear envelope even though the bouquet arrangement is aberrant, the normal bi-polar spindle can be formed. It was additionally shown that defects in chromosome segregation were not rescued in the bouquet mutants that forms normal bi-polar spindle. These results suggest that the defects in chromosome segregation in bouquet mutants should be caused by different mechanism from that of defects in spindle formation.
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