A new model of the self-organization of a complex ordered architecture, spiculous skeleton formation of demosponges
| Project/Area Number |
22370077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
FUNAYAMA Noriko 京都大学, 大学院・理学研究科, 准教授 (30276175)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 器官形成 / 骨片骨格 / カイメン / カワカイメン / シグナル経路 / パターニング / 細胞間相互作用 / 個体形成 / 発生ロジック / 位置情報 |
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| Research Abstract |
We approached to clarify the mechanisms that regulate the roughly evenly spaced pattern of spicule held up points in the first tier. We succeeded to establish a new original experimental system (sponge fusion experiment) and reviled that the spicules are transported and held up one by one (not simultaneously held up). We selected the inhibitors for several signaling pathways that can be expected to work in Ehydatia.fluviatilis according to the amino acids of their action sites in E.fluviatilis. Using these inhibitors, we succeeded to get candidate signaling path way that affects the pattern of spicule held up points. Identification of genes of this signaling pathway and the examination of the mRNA expression pattern of these genes suggested that the pattern of spicule held up points can not be explained by the simple pre-pattering in basopinaoderm.
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Report
(4 results)
Research Products
(13 results)
