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Technological development toward the artificial reproduction of the animal skin patterns.

Research Project

Project/Area Number 22370079
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionOsaka University

Principal Investigator

KONDO Shigeru  大阪大学, 生命機能研究科, 教授 (10252503)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsチューリング / ゼブラフィッシュ / 皮膚模様 / 反応拡散 / ネットワーク / 細胞学 / パターン形成 / 反応拡散系
Research Abstract

We aimed in this project to develop a method with which one can change the skin pattern of zebrafish in the vivo, and reproduce the pattern in culture dish (in vivo). Concerning to the in vivo changing of the pattern, using the cx418 gene transgenic fish, we succeeded to change the pattern of normal zebrafish (stripe) to variety of patterns. Although we have not yet succeeding to reproduce the pattern in culture dish, we established the method with which one can analyze the interactions between the pigment cells that plays the major role in the pattern formation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (55 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (33 results) (of which Invited: 6 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule igsf112012

    • Author(s)
      Eom, D.-S., *Inoue, S., Patterson, L. B., Gordon, T. N., Slingwine, R., Kondo, S., #Watanabe, M. & #Parichy, D. M.
    • Journal Title

      PLoS Genet.

      Volume: 8(8) Issue: 8 Pages: e1002899-e1002899

    • DOI

      10.1371/journal.pgen.1002899

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polyamine sensitivity of gap junctions is required for skin pattern formation in zebrafish2012

    • Author(s)
      Watanabe M, Watanabe D and Kondo S
    • Journal Title

      Scientific Reports

      Volume: 2 Pages: 473-473

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wing vein patterns of the Hemiptera insect Orosanga japonicus differ among individuals2012

    • Author(s)
      Yoshimoto E and Kondo S
    • Journal Title

      Interface Focus 6

      Volume: vol. 2 no. 4 Pages: 451-456

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changing clothes easily: connexin41.8 regulates skin pattern variation2012

    • Author(s)
      Watanabe M, Kondo S
    • Journal Title

      Pigment Cell Melanoma Res.

      Volume: 25(3) Pages: 326-30

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate2012

    • Author(s)
      Economou AD, Ohazama A, Porntaveetus T, Sharpe PT, Kondo S, Basson MA, Gritli-Linde A, Cobourne MT, GreenJB.
    • Journal Title

      Nat Genet.

      Volume: 44(3) Pages: 348-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pigment pattern formation by contact-dependent depolarization2012

    • Author(s)
      Inaba M, Yamanaka H, Kondo S
    • Journal Title

      Science

      Volume: Vol. 335 no. 6069 Pages: 677-677

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wing vein patterns of the Hemiptera insect Orosanga japonicus differ among individuals2012

    • Author(s)
      Yoshimoto, E.
    • Journal Title

      Interface Focus

      Volume: vol. 2 no. 4 Issue: 4 Pages: 451-456

    • DOI

      10.1098/rsfs.2011.0112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pigment pattern formation by contact-dependent depolarization2012

    • Author(s)
      Inaba, M.
    • Journal Title

      Science

      Volume: 335 Issue: 6069 Pages: 677-677

    • DOI

      10.1126/science.1212821

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changing clothes easily: connexin41.8 regulates skin pattern variation2012

    • Author(s)
      Watanabe, m., Kondo, S.
    • Journal Title

      Pigmnet Cell & Melanoma Reserch

      Volume: 25(3) Issue: 3 Pages: 326-330

    • DOI

      10.1111/j.1755-148x.2012.00984.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shh signaling is essential for rugae morphogenesis in mice2011

    • Author(s)
      Lee JM, Miyazawa S, Shin JO, Kwon HJ, Kang DW, Choi BJ, Lee JH, Kondo S, Cho SW, Jung HS
    • Journal Title

      Histochem Cell Biol.

      Volume: 136(6) Pages: 663-75

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate2011

    • Author(s)
      Economou AD
    • Journal Title

      Nature Genetics

      Volume: 44(3) Issue: 3 Pages: 348-351

    • DOI

      10.1038/ng.1090

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] チューリングパターンと動物のパターン形成2010

    • Author(s)
      吉元英一、近藤 滋
    • Journal Title

      脊椎動物の皮膚模様と昆虫の翅脈パターン、 生物科学

      Volume: 62(1) Pages: 2-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation2010

    • Author(s)
      Kondo S and Miura T
    • Journal Title

      Science

      Volume: 329(5999) Pages: 1616-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blending of animal colour patterns by hybridization2010

    • Author(s)
      Miyazawa S, Okamoto M, Kondo S
    • Journal Title

      Nat Commun.

      Volume: 1(6) Issue: 1

    • DOI

      10.1038/ncomms1071

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blending of animal colour patterns by hybridization2010

    • Author(s)
      Miyazawa S, Okamoto M, Kondo S
    • Journal Title

      Nature Communications

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation2010

    • Author(s)
      Kondo S, Miura T
    • Journal Title

      Science

      Volume: 329 Pages: 1616-1620

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Interaction among the pigment cells forms the Turing pattern in the skin of zebrafish2013

    • Author(s)
      近藤滋
    • Organizer
      国際高等研究所 研究プロジェクト 「ゲノム工学とイメージングサイエンスに基づく生命システム研究の新展開」2012 年度第一回研究会
    • Place of Presentation
      国際高等研究所(京都府)
    • Year and Date
      2013-02-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Collaboration of mathematical theory and experimental biology2013

    • Author(s)
      Shigeru Kondo
    • Organizer
      USGEB Annual Meeting 2013
    • Place of Presentation
      University of Zurich (Swiss Confederation)
    • Year and Date
      2013-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Zebrafish Pigment Patterning by Local Cell Interactions2013

    • Author(s)
      近藤滋
    • Organizer
      The 23rd CDB Meeting
    • Place of Presentation
      理化学研究所 (神戸市)
    • Year and Date
      2013-01-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Turing pattern without diffusion2012

    • Author(s)
      近藤滋
    • Organizer
      CDB Swiss Japanese Development Biology Meeting
    • Place of Presentation
      京都ガーデンパレス(京都市)
    • Year and Date
      2012-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Turing pattern without diffusion2012

    • Author(s)
      Shigeru Kondo
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Colby College(USA)
    • Year and Date
      2012-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Turing pattern formation without diffusion2012

    • Author(s)
      Shigeru Kondo
    • Organizer
      Turing Centenary Conference
    • Place of Presentation
      University of Cambridge, Cambridge(UK)
    • Year and Date
      2012-06-20
    • Related Report
      2012 Final Research Report
  • [Presentation] "波"が生み出す多彩な生命機能2012

    • Author(s)
      近藤滋
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館(松本市)
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanism of zebrafish skin pattern formation2012

    • Author(s)
      近藤滋
    • Organizer
      CDB SYMPOSIUM 2012
    • Place of Presentation
      理化学研究所(神戸市)
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Periodic pattern formation in the skin of animals2011

    • Author(s)
      Shigeru Kondo
    • Organizer
      International Symposium on Complex Systems 2011
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Periodic pattern formation in the skin of animals2011

    • Author(s)
      Shigeru Kondo
    • Organizer
      Internation Symposium on Complex Syetems 2011
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Skin pattern formation as a live Turing wave in animals2011

    • Author(s)
      近藤滋
    • Organizer
      名古屋大学2011GCOE 国際シンポジウム
    • Place of Presentation
      名古屋大学(名古屋市)
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Skin pattern formation as a live Turing wave in animals2011

    • Author(s)
      近藤滋
    • Organizer
      日本植物学会第75回大会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Skin pattern variation brought by the mutation in connexin41.8 of zebrafish2011

    • Author(s)
      Masakatsu Watanabe
    • Organizer
      International Gap Junction Conference 2011
    • Place of Presentation
      Ghent, Belgium
    • Year and Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Turing pattern in the real biological system2011

    • Author(s)
      Shigeru Kondo
    • Organizer
      BIRS Workshop
    • Place of Presentation
      Banff International Research Station , Banff(Canada)
    • Year and Date
      2011-07-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Turing pattern in the real biological system2011

    • Author(s)
      Shigeru Kondo
    • Organizer
      BIRS Workshop 11w5091
    • Place of Presentation
      Banff, Canada(招待講演)
    • Year and Date
      2011-07-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] How experiment and mathmatics can cooperate in the study of Turing patterns of real biological systems?2011

    • Author(s)
      Shigeru Kondo
    • Organizer
      8th European Conference on Mathematical and Theoretical Biology
    • Place of Presentation
      Jagiellonian University , Krakow(Poland)
    • Year and Date
      2011-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] How experiment and mathmatics can cooperate in the study of Turing patterns of real biological systems?2011

    • Author(s)
      Shigeru Kondo
    • Organizer
      8th European Conference on Mathematical and Theoretical Biology
    • Place of Presentation
      Krakow, Poland(招待講演)
    • Year and Date
      2011-06-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Interactions between zebrafish pigment cells responsible for the generation of Turing patterns2010

    • Author(s)
      Shigeru Kondo
    • Organizer
      16th Meeting of the European Society for Pigment Cell Research
    • Place of Presentation
      Welcome Trust Conference Centre , Cambridge(UK)
    • Year and Date
      2010-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Interactions between zebrafish pigment cells responsible for the generation of Turing patterns2010

    • Author(s)
      近藤滋
    • Organizer
      16th Meeting of the European Society for Pigment Cell Research
    • Place of Presentation
      Wellcome Trust Conference Centre, Cambridge(UK)(招待講演)
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Turing model, a framework for explaining biological pattern formation2010

    • Author(s)
      近藤滋
    • Organizer
      第43回日本発生生物学会大会
    • Place of Presentation
      国立京都国際会館、京都市
    • Year and Date
      2010-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Turing model, a framework for explaining biological pattern formation.2010

    • Author(s)
      近藤滋
    • Organizer
      第43回日本発生生物学会大会
    • Place of Presentation
      国立京都国際会館(招待講演)
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vitro analysis of the pigment cells for stripe pattern formation2010

    • Author(s)
      山中洋昭
    • Organizer
      The 9th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      Overture Center for the Arts, Madison(U.S.A.)
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of potassium channels in stripe pattern formation2010

    • Author(s)
      稲葉真史
    • Organizer
      The 9th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      Overture Center for the Arts, Madison(U.S.A.)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pattern formation in fixed 2D fields vs morphogenesis in growing 3D fields.2010

    • Author(s)
      近藤滋
    • Organizer
      Minerve 2010-Development of pattern in the nervous system
    • Place of Presentation
      La Bestide Les Aliberts, Minerve(France)(招待講演)
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Turing Pattern Formation Without Diffusion

    • Author(s)
      Shigeru Kondo
    • Organizer
      Turing Centenary Conference
    • Place of Presentation
      University of Cambridge (Cambridge, UK)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Zebrafish pigment cells arrange themselves into specific patterns through direct cell interactions

    • Author(s)
      Hiroaki Yamanaka
    • Organizer
      10th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      Overture Center (Madison, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Repulsive Movement of Pigment Cells Caused by Contact-Dependent Depolarization Contributes to Stripe Patterning

    • Author(s)
      Masafumi Inaba
    • Organizer
      10th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      Overture Center (Madison, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Turing pattern without diffusion

    • Author(s)
      Shigeru Kondo
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Colby College (Waterville, USA)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Turing pattern without diffusion

    • Author(s)
      Shigeru Kondo
    • Organizer
      CDB Swiss Japanese Development Biology Meeting
    • Place of Presentation
      京都ガーデンパレス(京都府)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Turing Pattern Formation without Diffusion

    • Author(s)
      Shigeru Kondo
    • Organizer
      The 23rd CDB Meeting
    • Place of Presentation
      理化学研究所(兵庫県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Collaboration of mathematical theory and experimental biology

    • Author(s)
      Shigeru Kondo
    • Organizer
      USGEB Annual Meeting 2013
    • Place of Presentation
      University of Zurich (Zurich, Swiss Confederation)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Interaction among the pigment cells forms the Turing pattern in the skin of zebrafish

    • Author(s)
      Shigeru Kondo
    • Organizer
      国際高等研究所 研究プロジェクト 「ゲノム工学とイメージングサイエンスに基づく生命システム研究の新展開」 2012年度第一回研究会
    • Place of Presentation
      国際高等研究所 (京都府)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Contribution of adhesion molecules in sikin pattern formation of zebrafish

    • Author(s)
      井上 新哉
    • Organizer
      第18回小型魚類研究会
    • Place of Presentation
      京都大学医学部芝欄会館(京都府)
    • Related Report
      2012 Annual Research Report
  • [Book] 反応拡散系による位置情報の形成、現代生物科学入門82010

    • Author(s)
      近藤滋
    • Publisher
      岩波書店
    • Related Report
      2012 Final Research Report
  • [Book] 現代生物科学入門8 システムバイオロジー2010

    • Author(s)
      近藤滋(共著)
    • Publisher
      岩波書店
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/skondo/

    • Related Report
      2012 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/skondo/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/skondo/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.fbs.osaka-u.ac.jp/labs/skondo/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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