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The physiological polymorphism of atherosclerosis investigated by genetic and environmental factors

Research Project

Project/Area Number 22370090
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied anthropology
Research InstitutionNagasaki University

Principal Investigator

MAEDA Takahiro  長崎大学, 医歯薬学総合研究科, 教授 (40284674)

Co-Investigator(Kenkyū-buntansha) NAKASHIMA Kenichirou  長崎大学, 医歯薬学総合研究科, 教授 (30039656)
TAKAMURA Noboru  長崎大学, 医歯薬学総合研究科, 教授 (30295068)
YAMASAKI Hironori  長崎大学, 保健・医療推進センター, 保健・医療推進センター (40346953)
KUSANO Yousuke  長崎大学, 医歯薬学総合研究科, 客員研究員 (70325637)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords動脈硬化 / 遺伝子多型 / 頸動脈内中膜複合体厚(CIMT) / 心臓足首血管指数(CAVI) / 頸動脈内中膜複合体厚 / 心臓足首血管指数 / MTHFR遺伝子 / Adiponectin遺伝子 / HDAC4遺伝子 / CARKL遺伝子 / アディポネクチン遺伝子
Research Abstract

Most cases of atherosclerosis result from the interactions of multiple genetic and environmental factors. To investigate the association between gene polymorphisms and clinical parameter of atherosclerosis such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), we conducted cross-sectional study of 1,295 Japanese (502 men and 793 women) who participated in a general health check in western rural community of the Goto Islands from 2000 to 2012. We analyzed polymorphisms of four genes such as MTHFR(rs1801133), HDAC4(rs3791398), CARKL(rs465563), and Adiponectin(rs1501299) which were reported the significant relation with atherosclerosis.The genotype distributions of four genes were as follows, MTHFR (CC: 43.2%, CT: 46.5%and TT: 10.3%), Adiponectin(GG: 53.7%, GT: 38.9%, and TT: 7.4%), HDAC4(GG: 80.4%, GA: 18.5%, and AA: 1.1%), and CARKL(GG: 12.7%, GA: 44.5%, and AA: 42.8%). No significant association between genotype and CAVI nor CIMT was observed. Next, we categorized into five groups based on the number of risky genotype and analyzed the association according to a group. Although no significant association was observed both in CIMT and CAVI, positive tendency was observed in CAVI. Further investigation with large number of participants is necessary to clarify the association between gene polymorphism and atherosclerosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2013 2012 2011 2010

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (13 results)

  • [Journal Article] Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old : a preliminary study2013

    • Author(s)
      Doi H, Nishitani S, Fujisawa TX, Nagai T, Kakeyama M, Maeda T, Shinohara K
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e59196-e59196

    • DOI

      10.1371/journal.pone.0059196

    • NAID

      120006985955

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Pilot Study of Allostatic Load among Elderly Japanese Living on Hizen-Oshima Island2012

    • Author(s)
      Crews DE, Harada H, Aoyagi K, Maeda T, Alfarano A, Sone Y, Kusano Y
    • Journal Title

      J Physiol Anthropol

      Volume: 31 Issue: 1

    • DOI

      10.1186/1880-6805-31-18

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lack of an association between E-selectin gene polymorphisms and the risk of Kawasaki disease2012

    • Author(s)
      Shirakawa T, Ikeda K, Nishimura S, Kuniba H, Nakashima K, Motomura H, Mizuno Y, Zaitsu M, Nakazato M, Maeda T, Hamasaki Y, Hara T, Moriuchi H
    • Journal Title

      Pediar Int

      Volume: 54 Pages: 455-460

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood folate concentration analyzed by microbiological assay and chemiluminescent immunoassay methods2012

    • Author(s)
      Nakazato M, Maeda T, Emura K, Maeda M, and Tamura T
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 58 Pages: 59-62

    • NAID

      130002103065

    • URL

      https://www.jstage.jst.go.jp/article/jnsv/58/1/58_59/_pdf

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood folate concentrations analyzed by microbiological assay and chemiluminescent immunoassay methods2012

    • Author(s)
      Nakazato M, Maeda T, Emura K, Maeda M, Tamura T
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 58 Pages: 59-62

    • NAID

      130002103065

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of an association between E-selectin gene polymorphisms and the risk of Kawasaki disease2012

    • Author(s)
      Shirakawa T, Ikeda K, Nishimura S, Kuniba H, Nakashima K, Motomura H, Mizuno Y, Zaitsu M, Nakazato M, Maeda T, Hamasaki Y, Hara T, Moriuchi H
    • Journal Title

      Pediatr Int

      Volume: Mar 13(Epub) Issue: 4 Pages: 455-60

    • DOI

      10.1111/j.1442-200x.2012.03608.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan2011

    • Author(s)
      Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, and Maeda T
    • Journal Title

      ACTA MEDICA NAGASAKIENSIA

      Volume: 55 Pages: 47-54

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults2011

    • Author(s)
      Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, and Tamura T
    • Journal Title

      Eur J Nutr

      Volume: 50 Issue: 7 Pages: 581-5

    • DOI

      10.1007/s00394-010-0165-0

    • NAID

      120006984813

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan.2011

    • Author(s)
      Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
    • Journal Title

      ACTA MEDICA NAGASAKIENSIA

      Volume: 55 Pages: 47-54

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults.2011

    • Author(s)
      Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, Tamura T
    • Journal Title

      Eur J Nutr

      Volume: Jan 8(Epub)

    • NAID

      120006984813

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism2010

    • Author(s)
      Takamura N, Hayashida N, and Maeda T
    • Journal Title

      JAMA

      Volume: 304(22) Issue: 22 Pages: 2481-2

    • DOI

      10.1001/jama.2010.1786

    • NAID

      120006984855

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] White blood cell count and cardiovascular biomarkers of atherosclerosis2010

    • Author(s)
      Sekitani Y, Hayashida N, Kadota K, Yamasaki H, Abiru N, Nakazato M, Maeda T, Ozono Y, and Takamura N
    • Journal Title

      Biomarkers

      Volume: 15(5) Pages: 454-60

    • NAID

      120006984914

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin to high-molecular-weight adiponectinratio is independently correlated with carotid intima-media thickness in men, but not in women2010

    • Author(s)
      Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, and Maeda T
    • Journal Title

      Biomarkers

      Volume: 15(4) Issue: 4 Pages: 340-4

    • DOI

      10.3109/13547501003735532

    • NAID

      120006984528

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism.2010

    • Author(s)
      Takamura N, Hayashida N, Maeda T
    • Journal Title

      JAMA

      Volume: 304 Pages: 2481-2482

    • NAID

      120006984855

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White blood cell count and cardiovascular biomarkers of atherosclerosis.2010

    • Author(s)
      Sekitani Y, Hayashida N, Kadota K, Yamasaki H, Abiru N, Nakazato M, Maeda T, Ozono Y, Takamura N
    • Journal Title

      Biomarkers

      Volume: 15 Pages: 454-460

    • NAID

      120006984914

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leptin to high-molecular-weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women.2010

    • Author(s)
      Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Aoyagi K, Ishibashi K, Nakazato M, Maeda T.
    • Journal Title

      Biomarkers

      Volume: 15 Pages: 340-344

    • NAID

      120006984528

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 長崎県の離島に住む高齢者の恒常性維持負荷度と食生活について2012

    • Author(s)
      岩本亜惟子、曽根良昭、草野洋介、青柳潔、前田隆浩、ダグラスクルーズ
    • Organizer
      第66回日本生理人類学会
    • Place of Presentation
      長崎大学医学部良順会館
    • Year and Date
      2012-05-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 動脈硬化関連遺伝子の多型解析2011

    • Author(s)
      中里未央、関田孝晴、前田隆浩、江村康介、高村昇、青柳潔、草野洋介
    • Organizer
      第64回日本生理人類学会
    • Place of Presentation
      九州大学大橋キャンパス
    • Year and Date
      2011-06-11
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 健診受診者3,908名における、内膜中膜複合体(IMT)と心臓足首血管指数(CAVI)に影響を与える因子の検討2011

    • Author(s)
      中里未央、関田孝晴、江村康介、門田耕一郎、和田光弘、前田隆浩、太田幹也
    • Organizer
      第2回日本病院総合診療医学会
    • Place of Presentation
      東北大学医学部艮陵会館
    • Year and Date
      2011-02-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 健診受診者3,908名における、内膜中膜複合体厚 (IMT) と心臓足首血管指数 (CAVI) に影響を与える因子の検討2011

    • Author(s)
      中里未央, 関田孝晴, 江村康介, 門田耕一郎, 和田光弘, 前田隆浩, 太田幹也
    • Organizer
      第2回日本病院総合診療医学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2011-02-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動脈硬化関連遺伝子の多型解析2010

    • Author(s)
      江村康佑、中里未央、関田孝晴、前田隆浩、小足公彦
    • Organizer
      第32回長崎県地域医療研究会
    • Place of Presentation
      長崎ブリックホール国際会議場
    • Year and Date
      2010-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 動脈硬化関連遺伝子の多型解析2010

    • Author(s)
      江村康介, 中里未央, 関田孝晴, 小足公彦, 前田隆浩
    • Organizer
      第32回長崎県地域医療研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動脈硬化関連遺伝子の多型解析2010

    • Author(s)
      長崎ブリックホール国際会議場
    • Organizer
      第6回五島地域医療研究会
    • Place of Presentation
      五島中央病院
    • Year and Date
      2010-09-28
    • Related Report
      2012 Final Research Report
  • [Presentation] ホモシステインと頸動脈内中膜複合体厚(CIMT)及び心臓足首指数(CAVI)との関連2010

    • Author(s)
      中里未央、関田孝晴、門田耕一郎、高村昇、中島憲一郎、吉谷清光、前田隆浩
    • Organizer
      第1回日本プライマリ・ケア連合学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-06-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ホモシステインと頸動脈内中膜複合体厚 (CIMT) 及び心臓足首血管指数 (CAVI) との関連2010

    • Author(s)
      中里未央, 関田孝晴, 門田耕一郎, 高村昇, 中島健一郎, 前田隆浩, 吉谷清光
    • Organizer
      第1回日本プライマリ・ケア連合学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 葉酸測定における微生物測定法(microbiologicalassay)と化学発光酵素免疫測定法(chemiluminescent enzyme immunoassay)の比較2010

    • Author(s)
      江村康佑, 中里未央, 関田孝晴, 前田隆浩, Kelly Johnston, 田村庸信, 太田幹也, 小足公彦
    • Organizer
      第59回日本医学検査学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Indices of atherosclerosis in relation to total homocysteine and blood folate levels in Japanese adults.2010

    • Author(s)
      M.Nakazato, T.Maeda N.Takamura, K.Kadota, K.Nakashima, T.Tamura.
    • Organizer
      Experimental Biology 2010
    • Place of Presentation
      Anaheim
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Microbiological assay とChemiluminescent immunoassayによる葉酸測定の比較2010

    • Author(s)
      江村康佑、中里未央、前田隆浩、太田幹也、Kelley Johnston、田村庸信
    • Organizer
      第59回日本医学検査学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Indices of atherosclerosis in relation to total homocysteine and blood folate levels in Japanese adults.2010

    • Author(s)
      Nakazato M, Maeda T, Takamura N, Kadota K, Nakashima K, and Tamura T
    • Organizer
      Experimental Biology 2010, American Society for Nutrition
    • Place of Presentation
      Anaheim Convention Center, Anaheim, California, USA
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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